Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001338.1:
Cluster 1Polyketide142813

BGC0001338, citrinin biosynthetic gene cluster from Monascus ruber. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Citrinin
ChemSpider ID: 10222475
SMILES string: Copy to clipboard
Molecular formula:
Average molecular mass: Da
Molecular activity: Cytotoxic

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Iterative type I
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
CITS
Iterative PKS subtype:
Non-reducing
Number of iterations:
4
C2-C7 first
Thioesterase type:
None
Release / cyclization type:
Reductive release

Gene cluster description

citrinin (BGC0001338). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank KT781075, positions 1-42813. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression, Gene expression correlated with compound production
MIxS-compliance:Unknown
Contact for this cluster:Russell Cox (University of Hannover)

Literature references

1. Yi He, Russell J. Cox. (2016) The molecular steps of citrinin biosynthesis in fungi. Chemical Science, vol. 7, no. 3, pp. 2119-2127