BGC0001338: citrinin biosynthetic gene cluster from Monascus ruber
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Location: 1 - 42,813 nt. (total: 42,813 nt).
This entry is originally from NCBI GenBank KT781075.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001338
Short description citrinin biosynthetic gene cluster from Monascus ruber
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Iterative type I)
Loci
KT781075.1
1 - 42813
via Knock-out studies, Heterologous expression, Gene expression correlated with compound production
Compounds
  • citrinin
Species Monascus ruber [taxonomy]
References
Chemical products information
citrinin Evidence: NMR, Mass spectrometry
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C13H14O5
Chemical database entries
NPAtlas
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ALI92648.1
  • citC
 274 - 2190 (-) CitC oxidoreductase
  • Tailoring
  • Other in vivo study
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  • ALI92649.1
  • citE
 2400 - 3342 (-) CitE dehydrogenase
  • Tailoring
  • Other in vivo study
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  • ALI92650.1
  • mrl5
 3863 - 4371 (+) MRL5 glyoxalase-like domain
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    • ALI92651.1
    • citD
    		 4816 - 6321 (+) CitD dehydrogenase
    • Tailoring
    • Other in vivo study
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    • ALI92652.1
    • mrl3
    		 6674 - 8390 (+) MRL3 Zn(II)2Cys6 Transcriptional regulator
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      • ALI92653.1
      • citB
      		 8845 - 9834 (-) CitB Fe(II)-dependent oxygenase
      • Tailoring
      • Other in vivo study
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      • ALI92654.1
      • citA
      		 10334 - 11119 (+) CitA serine hydrolase
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        • ALI92655.1
        • citS
        		 12814 - 20651 (+) CitS citrinin polyketide synthase
        • Scaffold biosynthesis
        • Other in vivo study
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        • ALI92656.1
        • mrr1
        		 20912 - 22589 (-) MRR1 Major Facilitator Superfamily (MFS) protein
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          • ALI92657.1
          • mrr2
          		 25050 - 26171 (+) MRR2 histidine phosphatase
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            • ALI92658.1
            • mrr3
            		 27029 - 28619 (+) MRR3 unknown protein
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              • ALI92659.1
              • mrr4
              		 29783 - 32025 (+) MRR4 WD40 protein
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                • ALI92660.1
                • mrr5
                		 34868 - 35533 (-) MRR5 carbonic anhydrases
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                  • ALI92661.1
                  • mrr6
                  		 37004 - 37706 (-) MRR6 unknown protein
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                    • ALI92662.1
                    • mrr7
                    		 38452 - 39771 (+) MRR7 enoyl-(Acyl carrier protein) reductase
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                      • ALI92663.1
                      • mrr8
                      		 40650 - 42813 (+) MRR8 AMP-binding enzyme
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                        Biosynthesis information
                        Annotation changelog

                        Entry version: 3

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-10-07
                        Update chemical activity to schema version 2.11
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 2

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2019-10-16
                        Migrated from v1.4
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2019-10-16
                        Updated compound(s) information (NPAtlas curation)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 1

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2016-09-03
                        Submitted
                        • (ID: 3XTF2R3BHL5LPPSMGJ2QHJQC)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        Detailed domain annotation
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