BGC0001338 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001338 (Monascus ruber)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	42,813	citrinin	Other	100%

BGC0001338 - Region 1 - T1PKS

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Location: 1 - 42,813 nt. (total: 42,813 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 42,814
Label		BGC0001338

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001338.1	0.95	Polyketide	citrinin	Monascus ruber
BGC0000099.1	0.38	Polyketide	monascorubrin	Talaromyces marneffei
BGC0001542.1	0.37	Polyketide	cercosporin	Cercospora zeina
BGC0001541.1	0.35	Polyketide	cercosporin	Cercospora beticola
BGC0000894.1	0.35	Other	citrinin	Monascus aurantiacus
BGC0000013.1	0.31	Polyketide	alternariol	Aspergillus nidulans FGSC A4
BGC0000161.1	0.29	Polyketide	isoterrein	Aspergillus terreus NIH2624
BGC0000048.1	0.29	Polyketide	dothistromin	Dothistroma septosporum
BGC0000046.1	0.26	Polyketide	depudecin	Alternaria brassicicola
BGC0001144.1	0.24	Polyketide	neosartoricin B	Trichophyton tonsurans CBS 112818

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001338.1	1.00	Polyketide	citrinin	Monascus ruber
BGC0000894.1	0.73	Other	citrinin	Monascus aurantiacus
BGC0000099.1	0.70	Polyketide	monascorubrin	Talaromyces marneffei
BGC0001542.1	0.70	Polyketide	cercosporin	Cercospora zeina
BGC0001541.1	0.68	Polyketide	cercosporin	Cercospora beticola
BGC0000013.1	0.65	Polyketide	alternariol	Aspergillus nidulans FGSC A4
BGC0000161.1	0.63	Polyketide	isoterrein	Aspergillus terreus NIH2624
BGC0000048.1	0.62	Polyketide	dothistromin	Dothistroma septosporum
BGC0000046.1	0.59	Polyketide	depudecin	Alternaria brassicicola
BGC0001144.1	0.58	Polyketide	neosartoricin B	Trichophyton tonsurans CBS 112818

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 40651:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

citS

PKS_AT (913..1210): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; Ethylmalonyl-CoA: 58.3%; Methylmalonyl-CoA: 58.3%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 52.4
Malonyl-CoA: 52.0
inactive: 48.1
Methylmalonyl-CoA: 47.2
Propionyl-CoA: 31.7
Ethylmalonyl-CoA: 26.3
CHC-CoA: 24.3
2-Methylbutyryl-CoA: 20.8
fatty_acid: 19.6
trans-1,2-CPDA: 16.4
Acetyl-CoA: 14.3
Benzoyl-CoA: 11.0
Isobutyryl-CoA: 8.9
3-Methylbutyryl-CoA: 0.0

mrr8

Search NORINE for peptide: strict or relaxed

AMP-binding (74..512): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: sslqf-f--k
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)