BGC0001339: squalestatin S1 biosynthetic gene cluster from Phoma sp. MF5453
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Location: 1 - 69,700 nt. (total: 69,700 nt).
This entry is originally from NCBI GenBank KU946987.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001339
Short description squalestatin S1 biosynthetic gene cluster from Phoma sp. MF5453
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Iterative type I)
Loci
KU946987.1
1 - 69700
via Knock-out studies, Enzymatic assays, Heterologous expression
Compounds
  • squalestatin S1
Species Phoma sp. MF5453 [taxonomy]
References
Chemical products information
squalestatin S1 Evidence: NMR, Mass spectrometry
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C35H46O13
Chemical database entries
NPAtlas
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AMY15054.1
  • mfL3
 46 - 4089 (-) transcription factor
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    • AMY15055.1
    • mfL2
    		 5098 - 6941 (+) MFS transporter
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      • AMY15056.1
      • mfL1
      		 8714 - 12825 (+) hypothetical protein
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        • AMY15057.1
        • mfpks1
        		 15080 - 23393 (-) tetraketide synthase MF-SQTKS
        • Scaffold biosynthesis
        • Other in vivo study
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        • AMY15058.1
        • mfM1
        		 23904 - 25116 (+) copper dependent oxygenase
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          • AMY15059.1
          • mfM2
          		 25936 - 27732 (+) MFS transporter
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            • AMY15060.1
            • mfM3
            		 28231 - 29304 (-) NADP dependent dehydrogenase
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              • AMY15061.1
              • mfM4
              		 30144 - 31634 (+) acyltransferase AT1
              • Tailoring
              • Knock-out
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              • AMY15062.1
              • mfM5
              		 34454 - 34834 (-) mfM5 protein
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                • AMY15063.1
                • mfM6
                		 37170 - 39091 (+) MFS transporter
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                  • AMY15064.1
                  • mfM7
                  		 40066 - 42358 (+) phenylalanine ammonia-lyase
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                    • AMY15065.1
                    • mfM8
                    		 42512 - 43583 (-) esterase/lipase
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                      • AMY15066.1
                      • mfM9
                      		 44065 - 45803 (-) acyl-CoA synthetase/ligase
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                        • AMY15067.1
                        • mfM10
                        		 46182 - 48142 (+) hydrolase
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                          • AMY15068.1
                          • mfpks2
                          		 48806 - 56980 (+) hexaketide synthase MF-SQHKS
                          • Scaffold biosynthesis
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                          • AMY15069.1
                          • mfR1
                          		 57584 - 58709 (-) putative non-heme iron dependent
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                            • AMY15070.1
                            • mfR2
                            		 59112 - 59993 (+) putative non-heme iron dependent
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                              • AMY15071.1
                              • mfR3
                              		 60271 - 61886 (-) citrate synthase
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                                • AMY15072.1
                                • mfR4
                                		 62500 - 63906 (+) acyltransferase-3 superfamily AT2
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                                  • AMY15073.1
                                  • mfR5
                                  		 64258 - 66006 (-) MFS transporter
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                                    • AMY15074.1
                                    • mfR6
                                    		 66436 - 67748 (+) squalene synthase
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                                      • AMY15075.1
                                      • mfR7
                                      		 68574 - 69577 (+) ab hydrolase
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                                        Biosynthesis information
                                        Annotation changelog

                                        Entry version: 4

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2022-10-07
                                        Update chemical activity to schema version 2.11
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                        Entry version: 3

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2022-09-15
                                        Corrected gene identifiers
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                        Entry version: 2

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2019-10-16
                                        Migrated from v1.4
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        2019-10-16
                                        Updated compound(s) information (NPAtlas curation)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                        Entry version: 1

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2016-09-03
                                        Submitted
                                        • (ID: 3XTF2R3BHL5LPPSMGJ2QHJQC)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        Detailed domain annotation
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