Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001339.1:
Cluster 1Polyketide169700

BGC0001339, squalestatin S1 biosynthetic gene cluster from Phoma sp. MF5453. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Squalestatin S1
ChemSpider ID: 4942838
SMILES string: Copy to clipboard
Molecular formula:
Average molecular mass: Da
Molecular activity: Antifungal, Inhibitor
Molecular target: squalene synthase

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Iterative type I
Starter unit:
Benzoyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
PHPKS1,PHPKS2
Iterative PKS subtype:
Highly reducing
5
Thioesterase type:
None
Release / cyclization type:
Unknown

Gene cluster description

squalestatin S1 (BGC0001339). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank KU946987, positions 1-69700. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays, Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Russell Cox (University of Hannover)

Literature references

1. B. Bonsch, V. Belt, C. Bartel, N. Duensing, M. Koziol, C. M. Lazarus, A. M. Bailey, T. J. Simpson, R. J. Cox. (2016) Identification of genes encoding squalestatin S1 biosynthesis and in vitro production of new squalestatin analogues. Chemical Communications, vol. 52, no. 41, pp. 6777-6780