BGC0001342 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001342 (Chondromyces crocatus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS	1	81,745	aculeximycin	Polyketide	14%

BGC0001342 - Region 1 - NRPS,T1PKS

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Location: 1 - 81,745 nt. (total: 81,745 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 81,746
Label		BGC0001342

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001342.1	1.40	NRP, Polyketide	Cmc-thuggacin A, Cmc-thuggacin B	Chondromyces crocatus
BGC0000041.1	0.75	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001164.1	0.64	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000067.1	0.60	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001273.1	0.59	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001244.1	0.59	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001276.1	0.58	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.1	0.58	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002057.1	0.54	Polyketide	pateamine	Kiritimatiellaeota bacterium
BGC0001235.1	0.54	NRP, Polyketide	antalid	Polyangium spumosum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001342.1	0.94	NRP, Polyketide	Cmc-thuggacin A, Cmc-thuggacin B	Chondromyces crocatus
BGC0000041.1	0.74	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001164.1	0.67	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000067.1	0.65	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001273.1	0.63	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001244.1	0.63	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001276.1	0.62	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.1	0.62	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001235.1	0.61	NRP, Polyketide	antalid	Polyangium spumosum
BGC0002057.1	0.61	Polyketide	pateamine	Kiritimatiellaeota bacterium

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 81745:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk - Me-redmal) + (ohmal - ohmal) + (ohmal - ccmal) + (ohmal - Me-ohmal - cys - Me-ccmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

tugA

PKS_AT (630..926): mmal

ATSignature: Methylmalonyl-CoA, Benzoyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 66.7%; Benzoyl-CoA: 66.7%; Ethylmalonyl-CoA: 58.3%

minowa: Benzoyl-CoA

Prediction, score:

Benzoyl-CoA: 163.7
Methylmalonyl-CoA: 127.5
Isobutyryl-CoA: 123.9
Methoxymalonyl-CoA: 104.4
Ethylmalonyl-CoA: 100.2
Malonyl-CoA: 81.8
Propionyl-CoA: 74.9
2-Methylbutyryl-CoA: 71.9
trans-1,2-CPDA: 69.6
CHC-CoA: 55.5
Acetyl-CoA: 53.0
3-Methylbutyryl-CoA: 41.2
inactive: 32.0
fatty_acid: 30.5

PKS_AT (1073..1370): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 207.3
Methylmalonyl-CoA: 206.8
Methoxymalonyl-CoA: 173.6
2-Methylbutyryl-CoA: 141.9
trans-1,2-CPDA: 138.2
CHC-CoA: 111.3
Malonyl-CoA: 107.7
Propionyl-CoA: 105.3
Isobutyryl-CoA: 83.7
Benzoyl-CoA: 77.3
Acetyl-CoA: 48.7
fatty_acid: 43.8
inactive: 33.4
3-Methylbutyryl-CoA: 24.3

PKS_AT (2853..3150): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 207.3
Methylmalonyl-CoA: 206.8
Methoxymalonyl-CoA: 173.6
2-Methylbutyryl-CoA: 141.9
trans-1,2-CPDA: 138.2
CHC-CoA: 111.3
Malonyl-CoA: 107.7
Propionyl-CoA: 105.3
Isobutyryl-CoA: 83.7
Benzoyl-CoA: 77.3
Acetyl-CoA: 48.7
fatty_acid: 43.8
inactive: 33.4
3-Methylbutyryl-CoA: 24.3

PKS_AT (4623..4920): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.7
Ethylmalonyl-CoA: 206.7
Methoxymalonyl-CoA: 176.7
2-Methylbutyryl-CoA: 143.6
trans-1,2-CPDA: 137.5
CHC-CoA: 111.9
Malonyl-CoA: 111.5
Propionyl-CoA: 103.9
Isobutyryl-CoA: 87.1
Benzoyl-CoA: 82.6
Acetyl-CoA: 51.3
fatty_acid: 43.5
inactive: 36.3
3-Methylbutyryl-CoA: 24.5

tugB

PKS_AT (550..849): mal

ATSignature: Malonyl-CoA, inactive

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 95.8%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.3
inactive: 127.3
Methoxymalonyl-CoA: 71.2
Methylmalonyl-CoA: 50.4
Propionyl-CoA: 32.9
Isobutyryl-CoA: 29.5
Benzoyl-CoA: 18.5
Acetyl-CoA: 17.4
Ethylmalonyl-CoA: 11.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2079..2380): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.1
inactive: 107.2
Methoxymalonyl-CoA: 55.8
Methylmalonyl-CoA: 54.4
Propionyl-CoA: 30.6
Isobutyryl-CoA: 27.3
Acetyl-CoA: 20.1
2-Methylbutyryl-CoA: 19.1
Benzoyl-CoA: 14.4
Ethylmalonyl-CoA: 13.8
fatty_acid: 8.4
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

tugC

PKS_AT (587..888): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 215.1
inactive: 101.6
Methoxymalonyl-CoA: 57.0
Methylmalonyl-CoA: 53.2
Propionyl-CoA: 31.3
Isobutyryl-CoA: 28.0
2-Methylbutyryl-CoA: 19.9
Acetyl-CoA: 17.3
Ethylmalonyl-CoA: 15.2
Benzoyl-CoA: 14.4
fatty_acid: 8.1
CHC-CoA: 1.2
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2156..2457): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.9
inactive: 107.3
Methoxymalonyl-CoA: 56.6
Methylmalonyl-CoA: 54.0
Propionyl-CoA: 31.0
Isobutyryl-CoA: 28.2
2-Methylbutyryl-CoA: 19.9
Acetyl-CoA: 18.2
Ethylmalonyl-CoA: 15.2
Benzoyl-CoA: 14.6
fatty_acid: 9.3
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

tugD

Search NORINE for peptide: strict or relaxed

PKS_AT (561..862): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.9
inactive: 112.6
Methoxymalonyl-CoA: 63.2
Methylmalonyl-CoA: 49.6
Propionyl-CoA: 30.4
Isobutyryl-CoA: 29.6
Acetyl-CoA: 20.7
Benzoyl-CoA: 19.9
2-Methylbutyryl-CoA: 10.7
Ethylmalonyl-CoA: 6.7
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2123..2420): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 201.0
Ethylmalonyl-CoA: 192.2
Methoxymalonyl-CoA: 174.6
2-Methylbutyryl-CoA: 130.3
trans-1,2-CPDA: 126.7
CHC-CoA: 101.4
Isobutyryl-CoA: 94.3
Malonyl-CoA: 92.0
Propionyl-CoA: 91.9
Benzoyl-CoA: 70.7
3-Methylbutyryl-CoA: 53.1
Acetyl-CoA: 44.6
fatty_acid: 40.6
inactive: 26.6

AMP-binding (3596..3995): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLwNLSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 90% (moderate)

PKS_AT (5081..5374): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 91.7%; Methoxymalonyl-CoA: 83.3%; Malonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 188.2
Ethylmalonyl-CoA: 175.6
Methoxymalonyl-CoA: 165.0
2-Methylbutyryl-CoA: 125.5
trans-1,2-CPDA: 116.4
Malonyl-CoA: 101.6
Isobutyryl-CoA: 84.2
Propionyl-CoA: 83.2
CHC-CoA: 81.6
Benzoyl-CoA: 60.2
Acetyl-CoA: 53.0
inactive: 50.6
fatty_acid: 31.1
3-Methylbutyryl-CoA: 30.9