BGC0001344: tubulysin A biosynthetic gene cluster from Cystobacter sp. SBCb004
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Location: 1 - 51,513 nt. (total: 51,513 nt).
This entry is originally from NCBI GenBank GU002154.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001344
Short description tubulysin A biosynthetic gene cluster from Cystobacter sp. SBCb004
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
GU002154.1
via
Compounds
  • tubulysin A
  • tubulysin B
  • tubulysin C
  • tubulysin D
  • tubulysin E
  • tubulysin F
  • tubulysin G
  • tubulysin H
  • tubulysin I
Species Cystobacter sp. SBCb004 [taxonomy]
References
Chemical products information
tubulysin A Evidence:
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C43H65N5O10S1
Chemical database entries
NPAtlas
PubCHEM
tubulysin B Evidence:
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C42H63N5O10S1
Chemical database entries
NPAtlas
PubCHEM
tubulysin C Evidence:
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C41H61N5O10S1
Chemical database entries
NPAtlas
PubCHEM
tubulysin D Evidence:
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C43H65N5O9S1
Chemical database entries
NPAtlas
PubCHEM
tubulysin E Evidence:
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C42H63N5O9S1
Chemical database entries
NPAtlas
PubCHEM
tubulysin F Evidence:
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C41H61N5O9S1
Chemical database entries
NPAtlas
PubCHEM
tubulysin G Evidence:
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C43H63N5O10S1
Chemical database entries
NPAtlas
PubCHEM
tubulysin H Evidence:
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C40H59N5O9S1
Chemical database entries
NPAtlas
PubCHEM
tubulysin I Evidence:
Copy SMILES
C40H59N5O10S1
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADH04671.1
 1 - 2208 (+) hypothetical protein
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    • ADH04672.1
    		 2283 - 6932 (+) hypothetical protein
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      • ADH04673.1
      		 7076 - 7897 (+) hypothetical protein
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        • ADH04674.1
        • tubA
        		 8019 - 9317 (+) TubA
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          • ADH04675.1
          		 9336 - 9995 (-) hypothetical protein
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            • ADH04676.1
            • tubZ
            		 9983 - 11143 (-) TubZ
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              • ADH04677.1
              		 11143 - 12327 (-) hypothetical protein
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                • ADH04678.1
                • tubB
                		 12483 - 17045 (+) non-ribosomal peptide synthetase
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                  • ADH04679.1
                  • tubC
                  		 17042 - 24928 (+) non-ribosomal peptide synthetase
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                    • ADH04680.1
                    • tubD
                    		 24918 - 35453 (+) hybrid polyketide synthase/non-ribosomal peptide synthetase
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                      • ADH04681.1
                      • tubE
                      		 35446 - 38931 (+) non-ribosomal peptide synthetase
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                        • ADH04682.1
                        • tubF
                        		 38938 - 47469 (+) polyketide synthase
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                          • ADH04683.1
                          		 47387 - 48400 (-) hypothetical protein
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                            • ADH04684.1
                            		 48472 - 49578 (-) hypothetical protein
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                              • ADH04685.1
                              		 49582 - 49956 (-) hypothetical protein
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                                • ADH04686.1
                                		 50228 - 50584 (+) hypothetical protein
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                                  • ADH04687.1
                                  		 50698 - 51513 (-) hypothetical protein
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                                    Biosynthesis information

                                    Biosynthetic modules

                                    Name
                                    Unk01
                                    Type
                                    nrps-type1
                                    Genes
                                    tubB
                                    Substrates
                                    pipecolic acid (evidence: Structure-based inference, Feeding study, Mass spectrometry)
                                    Integrated Monomers
                                    Domains
                                    adenylation
                                    Name
                                    Unk02
                                    Type
                                    nrps-type1
                                    Genes
                                    tubC
                                    Substrates
                                    isoleucine (evidence: Structure-based inference, Sequence-based prediction)
                                    Integrated Monomers
                                    Domains
                                    adenylation
                                    Name
                                    Unk03
                                    Type
                                    nrps-type1
                                    Genes
                                    tubC
                                    Substrates
                                    valine (evidence: Structure-based inference, Sequence-based prediction)
                                    Integrated Monomers
                                    Domains
                                    adenylation
                                    Name
                                    Unk04
                                    Type
                                    nrps-type1
                                    Genes
                                    tubD
                                    Substrates
                                    cysteine (evidence: Structure-based inference, Sequence-based prediction)
                                    Integrated Monomers
                                    Domains
                                    adenylation
                                    Annotation changelog

                                    Entry version: 3

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2022-09-15
                                    Added NRP substrate specificities
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 2

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2019-10-16
                                    Migrated from v1.4
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    2019-10-16
                                    Updated compound(s) information (NPAtlas curation)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 1

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2016-09-03
                                    Submitted
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    Detailed domain annotation
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