BGC0001345

BGC0001345: myxochelin A biosynthetic gene cluster from Stigmatella aurantiaca Sg a15

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Location: 1 - 19,653 nt. (total: 19,653 nt).
This entry is originally from NCBI GenBank AF299336.1.

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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General

Compounds

Genes

NRP

History

NRPS/PKS domains

KnownClusterBlast

General information about the BGC

MIBiG accession	BGC0001345
Short description	myxochelin A biosynthetic gene cluster from Stigmatella aurantiaca Sg a15
Status	Minimal annotation: no A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s) Completeness: Unknown Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)	NRP
Loci	NCBI GenBank: AF299336.1
Compounds	myxochelin A myxochelin B
Species	Stigmatella aurantiaca Sg a15 [taxonomy]
References	In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases. Gaitatzis N et al., Proc Natl Acad Sci U S A (2001) PMID:11562468 Myxochelin biosynthesis: direct evidence for two- and four-electron reduction of a carrier protein-bound thioester. Li Y et al., J Am Chem Soc (2008) PMID:18498160

Chemical products information

myxochelin A

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C₂₀H₂₄N₂O₇

Chemical database entries
NPAtlas
PubCHEM

myxochelin B

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C₂₀H₂₅N₃O₆

Chemical database entries
PubCHEM

List of genes involved in compound(s) production

Identifiers	Position	Product	Extra
AAG31124.1 mxcA	194 - 1174 (+)	MxcA	copy AA seq copy Nt seq
AAG31125.1 mxcB	1285 - 2097 (+)	MxcB	copy AA seq copy Nt seq
AAG31126.1 mxcC	2328 - 3101 (+)	MxcC	copy AA seq copy Nt seq
AAG31127.1 mxcD	3234 - 4460 (+)	MxcD	copy AA seq copy Nt seq
AAG31128.1 mxcE	4457 - 6088 (+)	MxcE	copy AA seq copy Nt seq
AAG31129.1 mxcF	6166 - 7101 (+)	MxcF	copy AA seq copy Nt seq
AAG31130.1 mxcG	7163 - 11533 (+)	MxcG	copy AA seq copy Nt seq
AAG31131.1 aroAA5	11580 - 13013 (+)	AroAA5	copy AA seq copy Nt seq
AAG31132.1 mxcH	13010 - 15619 (+)	MxcH	copy AA seq copy Nt seq
AAG31133.1 mxcI	15650 - 16894 (+)	MxcI	copy AA seq copy Nt seq
AAG31134.1 mxcK	17124 - 18347 (+)	MxcK	copy AA seq copy Nt seq
AAG31135.1 mxcL	18391 - 19653 (+)	MxcL	copy AA seq copy Nt seq

NRP-specific information

Subclass	N/A
Cyclic?	no

NRP-synthases

Gene	Modules
mxcE	Module ? Specificity: 2,3-dihydroxybenzoic acid Evidence for specificity:
mxcG	Module ? Specificity: lysine Evidence for specificity:

Annotation changelog

MIBiG version	Submitter	Notes
1.3	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Submitted
2.0	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Migrated from v1.4 Updated compound(s) information (NPAtlas curation)
3.0	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Updated bioactivity data Added NRP substrate specificities
3.1	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Update chemical activity to schema version 2.11

Detailed domain annotation

Selected features only

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Similar known gene clusters