BGC0001363: ralsolamycin biosynthetic gene cluster from Ralstonia solanacearum GMI1000
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Location: 777,576 - 820,777 nt. (total: 43,202 nt).
This entry is originally from NCBI GenBank AL646053.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001363
Short description ralsolamycin biosynthetic gene cluster from Ralstonia solanacearum GMI1000
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
AL646053.1
777576 - 820777
via
Compounds
  • ralsolamycin
Species Ralstonia solanacearum GMI1000 [taxonomy]
References
Chemical products information
ralsolamycin Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • RSp0638
  • CAD17789.1
 777576 - 779243 (-) probable cyclic peptide transporter; abc transporter protein
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    • RSp0639
    • CAD17790.1
    		 779369 - 780982 (-) probable zn-dependent hydrolase protein
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      • RSp0640
      • CAD17791.1
      		 781210 - 781416 (-) probable decoration of polyketide or non ribosomal peptide protein
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        • RSp0641
        • CAD17792.1
        		 782247 - 802916 (+) probable non ribosomal peptide synthetase protein
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          • RSp0642
          • CAD17793.1
          		 802916 - 820777 (+) probable non ribosomal peptide synthetase protein
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            Biosynthesis information

            Biosynthetic modules

            Name
            Unk01
            Type
            nrps-type1
            Genes
            RSp0641
            Substrates
            threonine (evidence: Structure-based inference, Sequence-based prediction)
            Integrated Monomers
            Domains
            adenylation
            Name
            Unk02
            Type
            nrps-type1
            Genes
            RSp0641
            Substrates
            tyrosine (evidence: Structure-based inference, Sequence-based prediction)
            Integrated Monomers
            Domains
            adenylation
            Name
            Unk03
            Type
            nrps-type1
            Genes
            RSp0641
            Substrates
            serine (evidence: Structure-based inference, Sequence-based prediction)
            Integrated Monomers
            Domains
            adenylation
            Name
            Unk04
            Type
            nrps-type1
            Genes
            RSp0641
            Substrates
            homoserine (evidence: ATP-PPi exchange assay, Structure-based inference)
            Integrated Monomers
            Domains
            adenylation
            Name
            Unk05
            Type
            nrps-type1
            Genes
            RSp0642
            Substrates
            valine (evidence: Structure-based inference, Sequence-based prediction)
            Integrated Monomers
            Domains
            adenylation
            Name
            Unk06
            Type
            nrps-type1
            Genes
            RSp0642
            Substrates
            serine (evidence: Structure-based inference, Sequence-based prediction)
            Integrated Monomers
            Domains
            adenylation
            Name
            Unk07
            Type
            nrps-type1
            Genes
            RSp0642
            Substrates
            glycine (evidence: Structure-based inference, Sequence-based prediction)
            Integrated Monomers
            Domains
            adenylation
            Name
            Unk08
            Type
            nrps-type1
            Genes
            RSp0642
            Substrates
            alanine (evidence: Structure-based inference, Sequence-based prediction)
            Integrated Monomers
            Domains
            adenylation
            Name
            Unk09
            Type
            nrps-type1
            Genes
            RSp0642
            Substrates
            beta-alanine (evidence: Structure-based inference, Sequence-based prediction)
            Integrated Monomers
            Domains
            adenylation
            Annotation changelog

            Entry version: 4

            Date
            Changes
            Submitters
            Reviewers
            2022-10-07
            Update chemical activity to schema version 2.11
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 3

            Date
            Changes
            Submitters
            Reviewers
            2022-09-15
            Merged annotations from duplicate entry BGC0001754
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-09-15
            Updated bioactivity data
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-09-15
            Added NRP substrate specificities
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 2

            Date
            Changes
            Submitters
            Reviewers
            2019-10-16
            Migrated from v1.4
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 1

            Date
            Changes
            Submitters
            Reviewers
            2016-09-03
            Submitted
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            Detailed domain annotation
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