BGC0001365 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001365 (Claviceps purpurea 20.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,indole	1	23,784	dithioclapurine/trithioclapurine/tetrathioclapurine	NRPS:Type I	100%

BGC0001365 - Region 1 - NRPS,indole

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Location: 1 - 23,784 nt. (total: 23,784 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
indole: (indsynth or dmat or indole_PTase)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 23,785
Label		BGC0001365

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001365	2.00	NRP	clapurines	Claviceps purpurea 20.1
BGC0002321	0.65	Other	pulcherriminic acid, pulcherrimin, cyclodileucine, compound 3	Metschnikowia aff. pulcherrima
BGC0002217	0.55	Terpene	HEx-tc3 terpene	Botrytis cinerea T4
BGC0000676	0.46	Terpene	aphidicolin, aphidicolan-16β-ol, 3-deoxyaphidicolin, 17-deoxyaphidicolin	Phoma betae
BGC0002208	0.46	NRP	oxepinamide F	Aspergillus ustus
BGC0000420	0.42	NRP	histidyltryptophanyldiketopiperazine, dehydrohistidyltryptophanyldiketopiperazine, roquefortine D, roquefortine C, glandicoline A, glandicoline B, meleagrine	Penicillium rubens Wisconsin 54-1255
BGC0000688	0.42	Terpene	copalyl diphosphate	Diaporthe amygdali
BGC0002242	0.41	NRP	oxepinamide D	Aspergillus ustus
BGC0002226	0.41	NRP	acu-dioxomorpholine B, acu-dioxomorpholine A	Aspergillus aculeatus ATCC 16872
BGC0001679	0.41	NRP	N-Acetyltryptophan	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001365	1.00	NRP	clapurines	Claviceps purpurea 20.1
BGC0002321	0.66	Other	pulcherriminic acid, pulcherrimin, cyclodileucine, compound 3	Metschnikowia aff. pulcherrima
BGC0002217	0.61	Terpene	HEx-tc3 terpene	Botrytis cinerea T4
BGC0000676	0.56	Terpene	aphidicolin, aphidicolan-16β-ol, 3-deoxyaphidicolin, 17-deoxyaphidicolin	Phoma betae
BGC0002208	0.56	NRP	oxepinamide F	Aspergillus ustus
BGC0000420	0.54	NRP	histidyltryptophanyldiketopiperazine, dehydrohistidyltryptophanyldiketopiperazine, roquefortine D, roquefortine C, glandicoline A, glandicoline B, meleagrine	Penicillium rubens Wisconsin 54-1255
BGC0000688	0.54	Terpene	copalyl diphosphate	Diaporthe amygdali
BGC0002242	0.53	NRP	oxepinamide D	Aspergillus ustus
BGC0002226	0.53	NRP	acu-dioxomorpholine B, acu-dioxomorpholine A	Aspergillus aculeatus ATCC 16872
BGC0001679	0.53	NRP	N-Acetyltryptophan	Aspergillus nidulans FGSC A4

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 23784:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Lys - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CPUR_02680

Search NORINE for peptide: strict or relaxed

AMP-binding (12..395): Lys

nrpys: Lys

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: N/A
Single AA prediction:: lys (Lys)

Stachelhaus prediction details:

Stachelhaus sequence:: DAGPFGAVSK
Nearest Stachelhaus code(s):: Trp DVGPFGACTK (62% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1070..1452): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVAMYIFIAK
Nearest Stachelhaus code(s):: Kyn DAAMIMGIAK (50% 8Å match); Asp DVWMYGAIVK (47% 8Å match)
Stachelhaus code match:: 60% (weak)