BGC0001371: echinocandin B biosynthetic gene cluster from Aspergillus nidulans NRRL 8112
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Location: 1 - 56,631 nt. (total: 56,631 nt).
This entry is originally from NCBI GenBank KT806042.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001371
Short description echinocandin B biosynthetic gene cluster from Aspergillus nidulans NRRL 8112
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
KT806042.1
via
Compounds
  • echinocandin B
Species Aspergillus nidulans NRRL 8112 [taxonomy]
References
Chemical products information
echinocandin B Evidence:
Copy SMILES
C52H81N7O16
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AMM63164.1
  • aniB
 973 - 3987 (-) AniB
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    • AMM63170.1
    • aniC
    		 4158 - 5596 (-) AniC
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      • AMM63171.1
      • aniD
      		 5801 - 7152 (+) AniD
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        • AMM63167.1
        • aniE
        		 7377 - 9253 (+) AniE
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          • AMM63174.1
          • aniF
          		 9379 - 10480 (-) AniF
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            • AMM63168.1
            • aniF2
            		 11854 - 13521 (-) AniF2
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              • AMM63162.1
              • aniA
              		 14131 - 36072 (+) AniA
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                • AMM63172.1
                • aniG
                		 36316 - 37468 (+) AniG
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                  • AMM63169.1
                  • aniH
                  		 37834 - 39399 (+) AniH
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                    • AMM63166.1
                    • aniI
                    		 39468 - 41408 (-) AniI
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                      • AMM63165.1
                      • aniJ
                      		 42952 - 45002 (+) AniJ
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                        • AMM63173.1
                        • aniK
                        		 45200 - 46315 (-) AniK
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                          • AMM63163.1
                          • aniL
                          		 46571 - 51788 (+) AniL
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                            Biosynthesis information

                            Biosynthetic modules

                            Name
                            Unk01
                            Type
                            nrps-type1
                            Genes
                            aniA
                            Substrates
                            ornithine (evidence: Radio labelling, Structure-based inference)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk02
                            Type
                            nrps-type1
                            Genes
                            aniA
                            Substrates
                            threonine (evidence: Structure-based inference [1])
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk03
                            Type
                            nrps-type1
                            Genes
                            aniA
                            Substrates
                            proline (evidence: Structure-based inference [1])
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk04
                            Type
                            nrps-type1
                            Genes
                            aniA
                            Substrates
                            homotyrosine (evidence: Radio labelling, Structure-based inference)
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk05
                            Type
                            nrps-type1
                            Genes
                            aniA
                            Substrates
                            threonine (evidence: Structure-based inference [1])
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk06
                            Type
                            nrps-type1
                            Genes
                            aniA
                            Substrates
                            3S-hydroxy-4S-methylproline (evidence: Structure-based inference [1])
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk07
                            Type
                            nrps-type1
                            Genes
                            aniI
                            Substrates
                            linoleic acid (evidence: Structure-based inference [1])
                            Integrated Monomers
                            Domains
                            adenylation
                            Annotation changelog

                            Entry version: next

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2024-07-27
                            MIBiG v4 annotathon
                            • (ID: 2U5WMR7MBJ4KI76XQF5437F7)
                            • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Added NRP substrate specificities
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Migrated from v1.4
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2016-09-03
                            Submitted
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            Detailed domain annotation
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