BGC0001371 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001371 (Aspergillus nidulans NRRL 8112)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,betalactone	1	56,631	pneumocandin B0 / pneumocandin A0	Polyketide + NRP + Other:Aminocoumarin	38%

BGC0001371 - Region 1 - NRPS,betalactone

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Location: 1 - 56,631 nt. (total: 56,631 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
betalactone: (HMGL-like and AMP-binding)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 56,632
Label		BGC0001371

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001371.1	1.85	NRP	echinocandin B	Aspergillus nidulans NRRL 8112
BGC0001220.1	0.83	NRP	aculeacin A	Aspergillus japonicus
BGC0001758.1	0.59	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001844.1	0.58	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001135.1	0.58	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.1	0.58	NRP	AM-toxin	Alternaria alternata
BGC0001166.1	0.56	NRP	HC-toxin	Alternaria jesenskae
BGC0001833.1	0.56	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001131.1	0.55	NRP	ambactin	Xenorhabdus miraniensis
BGC0001128.1	0.53	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001371.1	0.99	NRP	echinocandin B	Aspergillus nidulans NRRL 8112
BGC0001220.1	0.73	NRP	aculeacin A	Aspergillus japonicus
BGC0001758.1	0.63	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001131.1	0.63	NRP	ambactin	Xenorhabdus miraniensis
BGC0001844.1	0.63	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001135.1	0.63	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.1	0.62	NRP	AM-toxin	Alternaria alternata
BGC0001166.1	0.62	NRP	HC-toxin	Alternaria jesenskae
BGC0001833.1	0.61	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.1	0.60	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 56072:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - X - X - X - X - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

aniA

Search NORINE for peptide: strict or relaxed

AMP-binding (593..991): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: dvmelssitk
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

AMP-binding (1671..2073): X

NRPSPredictor2: hydrophilic

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: daqtavaihk
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

AMP-binding (2781..3175): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: dvssattvck
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

AMP-binding (3869..4272): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: dgeavgcifk
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

AMP-binding (4978..5381): X

NRPSPredictor2: hydrophilic

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: daqtivaihk
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

AMP-binding (6085..6484): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: dntmitamsk
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

aniI

Search NORINE for peptide: strict or relaxed

AMP-binding (30..459): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: gl-yiggvfk
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)