BGC0001372 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001372 (Penicillium thymicola)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	indole,NRPS	1	53,605	High	penigequinolone A	terpene

BGC0001372 - Region 1 - NRPS,indole

Download region GenBank file

Download region SVG

Location: 1 - 53,605 nt. (total: 53,605 nt) Show pHMM detection rules used

Region on contig edge.

indole: (indsynth or dmat or indole_PTase)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 53,606
Label		BGC0001372

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxygenase

ANY57880.1: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

ANY57882.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

ANY57886.1: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

Transferases: methyltransferase

ANY57881.1: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

ANY57889.1: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Hydrolases: hydrolase

ANY57888.1: isochorismatase

smcogs: SMCOG1027: isochorismatase

Ligases: ligase

ANY57892.1: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001372.3	0.91	terpene	penigequinolone A	Penicillium thymicola
BGC0000342.4	0.38	NRPS	enniatin	Fusarium equiseti
BGC0000307.4	0.33	NRPS	AbT1	Aureobasidium pullulans
BGC0001135.5	0.30	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.3	0.29	NRPS	AM-toxin	Alternaria alternata
BGC0001249.5	0.29	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001240.4	0.29	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002135.2	0.29	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001166.5	0.29	NRPS	HC-toxin	Alternaria jesenskae
BGC0000357.5	0.29	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001372.3	0.99	terpene	penigequinolone A	Penicillium thymicola
BGC0000342.4	0.71	NRPS	enniatin	Fusarium equiseti
BGC0000307.4	0.66	NRPS	AbT1	Aureobasidium pullulans
BGC0001135.5	0.63	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.3	0.63	NRPS	AM-toxin	Alternaria alternata
BGC0001249.5	0.63	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001240.4	0.63	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002135.2	0.62	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001166.5	0.62	NRPS	HC-toxin	Alternaria jesenskae
BGC0000357.5	0.62	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255

Similar known clusters from MIBiG 4.0

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 5708 - 53605:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - NMe-X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 24920 - 53605:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - NMe-X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ANY57892.1: X - X

AMP-binding (234..625): X

nrpys: Phe, Trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GMIIVAAICK
Nearest Stachelhaus code(s):: 4clBza or 2clBza GVIILAAGIK (59% 8Å match); S-bohPhe or Phe DALIVAAVCK (38% 8Å match); bOH-Tyr DTSKVAAICK (35% 8Å match)
Stachelhaus code match:: 60% (weak)

AMP-binding (1327..1731): X

nrpys: Leu, Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAFFYGVVVK
Nearest Stachelhaus code(s):: Leu or Ile DAFFLGNVVK (59% 8Å match)
Stachelhaus code match:: 80% (moderate)

Link to PARAS substrate predictor