BGC0001391 - 1 region(s) - antiSMASH results

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	lanthipeptide-class-ii	1	10,393	High	thusin	ribosomal:RiPP

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 10,394
Label		BGC0001391

Tailoring functions

Lyases: cyclase

thsM1: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

thsM2: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001391.3	1.00	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0001311.5	0.57	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000520.5	0.55	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000623.3	0.54	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000626.3	0.53	ribosomal	thuricin	Bacillus thuringiensis
BGC0001229.4	0.53	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000532.3	0.51	ribosomal	mutacin II	Streptococcus mutans
BGC0000554.4	0.51	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000552.3	0.50	ribosomal	SmbA, SmbB	Streptococcus mutans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001391.3	1.00	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0001311.5	0.57	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000520.5	0.55	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000623.3	0.54	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000626.3	0.53	ribosomal	thuricin	Bacillus thuringiensis
BGC0001229.4	0.53	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000532.3	0.51	ribosomal	mutacin II	Streptococcus mutans
BGC0000554.4	0.51	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000552.3	0.50	ribosomal	SmbA, SmbB	Streptococcus mutans

Similar known clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for thsM1

thsA1

Leader:

MLDVIKNRKKIEEKLELPEILLEEVEEHSAMGG

Core:

INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG

Core with dehydrations:

INDhbWNDhbDhbADhbDhaDhbDhaIIIDhaEDhbFGNKGKVCysDhbYDhbVECysVNNCysRG

antiSMASH-DB 4.0 matches for thsA1

100.0%

NZ_CM000756.1and 7 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide

Lanthipeptides: BTHUR0011_RS34475_lanthipeptide

1

INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG

38

INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG

1

INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG

38

71.1%

NZ_JAGKQT010000007.1and 3 others:

NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09860_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide

Lanthipeptides: J2M30_RS09860_lanthipeptide

2

NTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCR

37

NTWNT +TST I +S GN GKVCTYTVECVNNCR

1

NTWNTISTSTCIAVSHFVGNDGKVCTYTVECVNNCR

36

63.2%

NZ_CP047645.1and 7 others:

NZ_CP047645.1 Lanthipeptides: GSN02_RS17445_lanthipeptideNZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptideNZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptide

Lanthipeptides: GSN02_RS17445_lanthipeptide

1

INTWNTTATST-SIIISETFGNKGKVCTYTVECVNNC

36

NTWNTT TS +I++SE FGNKGKVCT T EC C

1

FNTWNTTTTSVGTILVSEVFGNKGKVCTGTKECQGTC

37

with 103 more sequence matches

Only the first 10 are displayed here.

60.5%

NZ_CP017953.1and 27 others:

NZ_CP017953.1 Lanthipeptides: BAMY_RS16400_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptideNZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptideNZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide

Lanthipeptides: BAMY_RS16400_lanthipeptide

1

INTWNTTATSTS-IIISETFGNKGKVCTYTVECVNNC

36

NTWNTT TS I++SE GNKGKVCT T EC C

1

FNTWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

52.6%

NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS25150_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide

Lanthipeptides: PDUR_RS25150_lanthipeptide

5

NTTATSTSIIISETFGNKGKVCTYTVECVNNC

36

NT TSTSI+IS T GN G VCT T EC+ +C

4

NTLTTSTSILISMTLGNNGWVCTATKECMPSC

35

51.3%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide

Lanthipeptides: MT347_RS12955_lanthipeptide

4

WNTTATS-TSIIISETFGNKGKVCTYTVECVNNC

36

W TT TS T +S GN G+VCT TVEC NNC

5

WTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

47.4%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS01820_lanthipeptide

Lanthipeptides: P40081_RS01820_lanthipeptide

5

NTTATSTSIIISETFGNKGKVCTYTVECVNNC

36

NT TSTSI IS GN G VCT++ EC+ +C

4

NTLTTSTSIFISRGLGNDGWVCTWSKECMPSC

35

47.4%

NZ_JAQFWW010000002.1and 1 other:

NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide

Lanthipeptides: PDT38_RS11330_lanthipeptide

3

TWNTTATSTSIIISETF-GNKGKVCTYTVECVNNCR

37

+W T T+ S + + G+KG+VCT TVEC NNCR

2

SWGTLLTTLSCLAASIMIGDKGQVCTGTVECQNNCR

37

47.4%

NZ_LT575476.1and 1 other:

NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide

Lanthipeptides: BN6628_RS02285_lanthipeptide

3

TWNTTATSTSII-ISETFGNKGKVCTYTVECVNNCR

37

+W T T+ + + S G+KG+VCT TVEC+NNCR

2

SWGTVLTTLACLGASYALGDKGQVCTATVECINNCR

37

44.7%

NC_017299.1and 1 other:

NC_017299.1 Lanthipeptides: H04402_RS03105_lanthipeptide

Lanthipeptides: H04402_RS03105_lanthipeptide

12

SIIISETFGNKGKVCTYTVECVNNC

36

SI +S GN GKVCT+TVEC NNC

8

SITLSVYMGNDGKVCTWTVECQNNC

32

44.7%

NZ_CKMQ01000043.1and 10 others:

NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS11585_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptideNZ_LR216041.1 Lanthipeptides: E0F00_RS05465_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptideNZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptideNZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptide

Lanthipeptides: AE832_RS11585_lanthipeptide

14

IISETFGNKGKVCTYTVECVNNCR

37

ISE GNKG VCT T+EC NNCR

7

FISEALGNKGAVCTGTIECQNNCR

30

42.1%

NZ_BMRY01000003.1and 24 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide

Lanthipeptides: IE140_RS12370_lanthipeptide

4

WNTTATSTSII-ISETFGNKGKVCTYTVECVNNCR

37

W T +S S S GN G CT T EC NNC+

4

WGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

42.1%

NZ_CP116355.1and 1 other:

NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide

Lanthipeptides: KPP03845_RS17815_lanthipeptide

4

WNTTATSTSII-ISETFGNKGKVCTYTVECVNNCR

37

W T +S S S GN G CT T EC NNC+

4

WGTVMSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

MIBiG 4.0 matches for thsA1

34.2%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

15

ISETFGNKGKVCTYTVECVNNC

36

IS GNKG CT TVEC+ +C

6

ISCRLGNKGAYCTLTVECMPSC

27

31.6%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

9

TSTSIIISETFGNKGKVCTYTVECVNNC

36

T+ + +S GN G CT T EC NC

2

TTNTFSLSNALGNNGGWCTLTKECQPNC

29

15.4%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

26

CTYTVECVNNC

36

CT + EC NC

28

CTLSKECQPNC

38

thsA2

Leader:

MLKEEKLEKITGLIPESELEEHLSG

Core:

ESSGAGTPAITTAISAIIAATAQSPCPTSACSKSCNK

Core with dehydrations:

EDhaDhaGAGDhbPAIDhbDhbAIDhaAIIAADhbAQDhaPCysPDhbDhaACysDhaKDhaCysNK

antiSMASH-DB 4.0 matches for thsA2

89.2%

NZ_CM000756.1and 17 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide

Lanthipeptides: BTHUR0011_RS14765_lanthipeptide

1

ESSGAGTPAITTAISAIIAATAQSPCPTSACSKSCNK

37

ESSGAGTPAI TAISA+ A TAQSPCPTSACSKSCNK

1

ESSGAGTPAIVTAISAVTAVTAQSPCPTSACSKSCNK

37

67.6%

NZ_JAGKQT010000007.1and 3 others:

NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09845_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05870_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05870_lanthipeptide

Lanthipeptides: J2M30_RS09845_lanthipeptide

6

GTPAITTAISAIIAATAQSPCPTSACSKSC

35

GTPAI +AISAI A T QSPCPTSACSKSC

1

GTPAIFSAISAITAVTVQSPCPTSACSKSC

30

48.7%

NZ_WHOM01000078.1and 1 other:

NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29290_lanthipeptide

Lanthipeptides: GCN81_RS29290_lanthipeptide

1

ESSGAG-TPAITTAISAIIAATA--QSPCPTSACSKSC

35

ES AG TP I A I+ A+A Q CPTS C+K C

2

ESLAAGITPTILPATGVIVGASAALQGGCPTSGCTKRC

39

with 69 more sequence matches

Only the first 10 are displayed here.

48.6%

NZ_CP086141.1and 1 other:

NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide

Lanthipeptides: LL065_RS24780_lanthipeptide

13

AISAIIA-ATAQSPC--PTSACSKSCNK

37

AISA +A ATA S TSAC+KSCNK

3

AISATVASATAVSALFTVTSACTKSCNK

30

48.6%

NZ_CP086141.1and 1 other:

NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide

Lanthipeptides: LL065_RS24780_lanthipeptide

10

ITTAISAIIA-ATAQSPC--PTSACSKSCNK

37

+ +AISA +A ATA S TSAC+KSCNK

4

VVSAISATVASATAVSALFTVTSACTKSCNK

34

45.2%

NZ_BNBJ01000003.1and 9 others:

NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05295_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptide

Lanthipeptides: IE304_RS05295_lanthipeptide

1

ESSGAG-TPAIT--TAISAII---AATAQSPCPTSACSKSC

35

ES AG TP I TA++ +I +A Q CPTS C+K C

2

ESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

43.2%

NZ_CP047645.1and 5 others:

NZ_CP047645.1 Lanthipeptides: GSN02_RS17435_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptide

Lanthipeptides: GSN02_RS17435_lanthipeptide

6

GTP--AITTAISA--IIAATAQSPCPTSACSKSCNK

37

GTP AI TA++ + + CPTSAC+ CNK

1

GTPVTAIITALTGTTFTVTLSAASCPTSACTNLCNK

36

43.2%

NZ_JALAUA010000003.1and 1 other:

NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04870_lanthipeptide

Lanthipeptides: MOD32_RS04870_lanthipeptide

6

GTP--AITTAISA--IIAATAQSPCPTSACSKSCNK

37

GTP AI TA++ + + CPTSAC+ CNK

1

GTPVTAILTALTGTTFTVTLSAASCPTSACTNLCNK

36

40.5%

NZ_CP015591.1and 15 others:

NZ_CP078085.1 Lanthipeptides: KU891_RS29355_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29350_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29345_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29340_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29335_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide

Lanthipeptides: A7A70_RS27550_lanthipeptide

7

TPAITTAISAIIAATAQSPCPTSACSKSC

35

TPA T + A IAAT S CPT+ C+ C

8

TPATPTIVEATIAATV-SICPTTKCTSRC

35

40.5%

NZ_JACSPO010000013.1and 1 other:

NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14885_lanthipeptide

Lanthipeptides: H9624_RS14885_lanthipeptide

5

AGTPAITTAISA-IIAATAQSP--CPTSACSKSC

35

AGT + AI +IA +A P CPT AC+ C

1

AGTTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

40.5%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

1

ESSGAGTPAITTAISAIIAATAQSPCPTSACS---KSCN

36

ES+ GTPA +S I CPT+ C+ +SCN

2

ESTPNGTPATIIPVSLAI-------CPTTRCASIVESCN

33

40.5%

NZ_QORY01000016.1and 1 other:

NZ_QORY01000016.1 Lanthipeptides: DT250_RS18265_lanthipeptide

Lanthipeptides: DT250_RS18265_lanthipeptide

3

SGAGTPAITTAISAIIAATAQSPCPTSACSKSC

35

SG TP TT AI + + CPT+ACS C

1

SGEVTP-YTTWGCAIFTIASAAQCPTTACSSKC

32

39.1%

NZ_JAJAGO010000028.1and 1 other:

NZ_JAJAGO010000028.1 Lanthipeptides: LHJ74_RS33595_lanthipeptide

Lanthipeptides: LHJ74_RS33595_lanthipeptide

1

ESSGAGTPAITTAISAIIAATAQSPCPTSACSKSC

35

E+ G +PA T++ + I AAT S CPTSACS C

13

EAFGGTSPATTSSWTCITAATI-SICPTSACSSKC

46

MIBiG 4.0 matches for thsA2

32.4%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

8

PAITTAISAIIAATA-------QSPCPTSACSKSC

35

PA+T I I+A A + CPT+ C+ C

3

PAVTGLILGIVAIQAGVAVGVSAAFCPTTKCTSRC

37

21.6%

BGC0002130.3 (QKI29070.1):

Lanthipeptide: cacaoidin

10

ITTAISAIIAATAQSPC

26

I ++SA I+ATA C

7

IYASVSASISATASWGC

23

11.8%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

1

ESSGAGTPAITT

12

ESS PA T

31

ESSRPAAPACHT

42

with 1 more sequence matches

10.8%

BGC0000581.6 (AAD28494.1):

Lasso peptide: microcin J25

4

GAGTP

8

G GTP

12

GIGTP

16

thsA2_

Leader:

MKEQKLEKITGLIPESELEEHLSGESSGAGTPAITTAISAIIGA

Core:

TAQSPCPTSACSKSCNK

Core with dehydrations:

DhbAQDhaPCysPDhbDhaACysDhaKDhaCysNK

antiSMASH-DB 4.0 matches for thsA2_

46.7%

NZ_JAGKQT010000007.1and 3 others:

NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09845_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05870_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05870_lanthipeptide

Lanthipeptides: J2M30_RS09845_lanthipeptide

1

TAQSPCPTSACSKSC

15

T QSPCPTSACSKSC

16

TVQSPCPTSACSKSC

30

45.9%

NZ_CM000756.1and 17 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide

Lanthipeptides: BTHUR0011_RS14765_lanthipeptide

1

TAQSPCPTSACSKSCNK

17

TAQSPCPTSACSKSCNK

21

TAQSPCPTSACSKSCNK

37

41.2%

NZ_CP061033.1and 1 other:

NZ_CP061033.1 Lanthipeptides: IAU67_RS09325_lanthipeptide

Lanthipeptides: IAU67_RS09325_lanthipeptide

6

CPTSACSKSC

15

CPTS C+ SC

7

CPTSGCTHSC

16

with 47 more sequence matches

Only the first 10 are displayed here.

41.2%

NZ_CP116355.1and 1 other:

NZ_CP116355.1 Lanthipeptides: KPP03845_RS17825_lanthipeptide

Lanthipeptides: KPP03845_RS17825_lanthipeptide

6

CPTSACSKSC

15

CPTS C+K C

1

CPTSGCTKRC

10

35.3%

NZ_BMVL01000013.1and 1 other:

NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28640_lanthipeptide

Lanthipeptides: IE257_RS28640_lanthipeptide

6

CPTSACSKSC

15

CPTS C+ C

1

CPTSGCTGRC

10

35.3%

NZ_GG657754.1and 1 other:

NZ_GG657754.1 Lanthipeptides: SSOG_RS27835_lanthipeptide

Lanthipeptides: SSOG_RS27835_lanthipeptide

6

CPTSACSKSC

15

CPTS C+ C

1

CPTSGCTSKC

10

35.3%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS31015_lanthipeptide

Lanthipeptides: CN325_RS31015_lanthipeptide

6

CPTSACSKSCN

16

CPTS C+ C

3

CPTSKCTTRCG

13

35.3%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS08060_lanthipeptide

Lanthipeptides: DEI99_RS08060_lanthipeptide

6

CPTSACSKSC

15

CPT AC+ C

8

CPTGACTSKC

17

35.0%

NZ_WITJ01000001.1and 1 other:

NZ_WITJ01000001.1 Lanthipeptides: GHI93_RS00070_lanthipeptide

Lanthipeptides: GHI93_RS00070_lanthipeptide

8

TSACSKSC

15

T+ACSKSC

10

TTACSKSC

17

33.3%

NZ_CP102975.1and 1 other:

NZ_FMOE01000002.1 Lanthipeptides: BJT27_RS07810_lanthipeptide

Lanthipeptides: NW953_RS00175_lanthipeptide

1

TAQSPCPTSACSKSCNK

17

TAQ CPT ACS C K

16

TAQ--CPTLACSSRCGK

30

30.0%

NZ_CP086141.1and 3 others:

NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptideNZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptideNZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide

Lanthipeptides: LL065_RS24780_lanthipeptide

8

TSACSKSCNK

17

TSAC+KSCNK

21

TSACTKSCNK

30

28.6%

NZ_CP115450.1and 1 other:

NZ_CP115450.1 Lanthipeptides: O1G21_RS35405_lanthipeptide

Lanthipeptides: O1G21_RS35405_lanthipeptide

6

CPTSACSKSC

15

CPT+AC+ C

12

CPTTACTSRC

21

28.0%

NZ_KI632509.1and 1 other:

NZ_KI632509.1 Lanthipeptides: AMYHA_RS26410_lanthipeptide

Lanthipeptides: AMYHA_RS26410_lanthipeptide

1

TAQSPCPTSAC

11

T QS CP S C

15

TCQSACPNSGC

25

Lanthipeptide(s) for thsM2

thsA1

Leader:

MLDVIKNRKKIEEKLELPEILLEEVEEHSAMGG

Core:

INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG

Core with dehydrations:

INDhbWNDhbDhbADhbDhaDhbDhaIIIDhaEDhbFGNKGKVCysDhbYDhbVECysVNNCysRG

antiSMASH-DB 4.0 matches for thsA1

100.0%

NZ_CM000756.1and 7 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide

Lanthipeptides: BTHUR0011_RS34475_lanthipeptide

1

INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG

38

INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG

1

INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG

38

71.1%

NZ_JAGKQT010000007.1and 3 others:

NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09860_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide

Lanthipeptides: J2M30_RS09860_lanthipeptide

2

NTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCR

37

NTWNT +TST I +S GN GKVCTYTVECVNNCR

1

NTWNTISTSTCIAVSHFVGNDGKVCTYTVECVNNCR

36

63.2%

NZ_CP047645.1and 7 others:

NZ_CP047645.1 Lanthipeptides: GSN02_RS17445_lanthipeptideNZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptideNZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptide

Lanthipeptides: GSN02_RS17445_lanthipeptide

1

INTWNTTATST-SIIISETFGNKGKVCTYTVECVNNC

36

NTWNTT TS +I++SE FGNKGKVCT T EC C

1

FNTWNTTTTSVGTILVSEVFGNKGKVCTGTKECQGTC

37

with 103 more sequence matches

Only the first 10 are displayed here.

60.5%

NZ_CP017953.1and 27 others:

NZ_CP017953.1 Lanthipeptides: BAMY_RS16400_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptideNZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptideNZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide

Lanthipeptides: BAMY_RS16400_lanthipeptide

1

INTWNTTATSTS-IIISETFGNKGKVCTYTVECVNNC

36

NTWNTT TS I++SE GNKGKVCT T EC C

1

FNTWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

52.6%

NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS25150_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide

Lanthipeptides: PDUR_RS25150_lanthipeptide

5

NTTATSTSIIISETFGNKGKVCTYTVECVNNC

36

NT TSTSI+IS T GN G VCT T EC+ +C

4

NTLTTSTSILISMTLGNNGWVCTATKECMPSC

35

51.3%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide

Lanthipeptides: MT347_RS12955_lanthipeptide

4

WNTTATS-TSIIISETFGNKGKVCTYTVECVNNC

36

W TT TS T +S GN G+VCT TVEC NNC

5

WTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

47.4%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS01820_lanthipeptide

Lanthipeptides: P40081_RS01820_lanthipeptide

5

NTTATSTSIIISETFGNKGKVCTYTVECVNNC

36

NT TSTSI IS GN G VCT++ EC+ +C

4

NTLTTSTSIFISRGLGNDGWVCTWSKECMPSC

35

47.4%

NZ_JAQFWW010000002.1and 1 other:

NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide

Lanthipeptides: PDT38_RS11330_lanthipeptide

3

TWNTTATSTSIIISETF-GNKGKVCTYTVECVNNCR

37

+W T T+ S + + G+KG+VCT TVEC NNCR

2

SWGTLLTTLSCLAASIMIGDKGQVCTGTVECQNNCR

37

47.4%

NZ_LT575476.1and 1 other:

NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide

Lanthipeptides: BN6628_RS02285_lanthipeptide

3

TWNTTATSTSII-ISETFGNKGKVCTYTVECVNNCR

37

+W T T+ + + S G+KG+VCT TVEC+NNCR

2

SWGTVLTTLACLGASYALGDKGQVCTATVECINNCR

37

44.7%

NC_017299.1and 1 other:

NC_017299.1 Lanthipeptides: H04402_RS03105_lanthipeptide

Lanthipeptides: H04402_RS03105_lanthipeptide

12

SIIISETFGNKGKVCTYTVECVNNC

36

SI +S GN GKVCT+TVEC NNC

8

SITLSVYMGNDGKVCTWTVECQNNC

32

44.7%

NZ_CKMQ01000043.1and 10 others:

NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS11585_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptideNZ_LR216041.1 Lanthipeptides: E0F00_RS05465_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptideNZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptideNZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptide

Lanthipeptides: AE832_RS11585_lanthipeptide

14

IISETFGNKGKVCTYTVECVNNCR

37

ISE GNKG VCT T+EC NNCR

7

FISEALGNKGAVCTGTIECQNNCR

30

42.1%

NZ_BMRY01000003.1and 24 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide

Lanthipeptides: IE140_RS12370_lanthipeptide

4

WNTTATSTSII-ISETFGNKGKVCTYTVECVNNCR

37

W T +S S S GN G CT T EC NNC+

4

WGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

42.1%

NZ_CP116355.1and 1 other:

NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide

Lanthipeptides: KPP03845_RS17815_lanthipeptide

4

WNTTATSTSII-ISETFGNKGKVCTYTVECVNNCR

37

W T +S S S GN G CT T EC NNC+

4

WGTVMSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

MIBiG 4.0 matches for thsA1

34.2%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

15

ISETFGNKGKVCTYTVECVNNC

36

IS GNKG CT TVEC+ +C

6

ISCRLGNKGAYCTLTVECMPSC

27

31.6%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

9

TSTSIIISETFGNKGKVCTYTVECVNNC

36

T+ + +S GN G CT T EC NC

2

TTNTFSLSNALGNNGGWCTLTKECQPNC

29

15.4%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

26

CTYTVECVNNC

36

CT + EC NC

28

CTLSKECQPNC

38

thsA2

Leader:

MLKEEKLEKITGLIPESELEEHLSG

Core:

ESSGAGTPAITTAISAIIAATAQSPCPTSACSKSCNK

Core with dehydrations:

EDhaDhaGAGDhbPAIDhbDhbAIDhaAIIAADhbAQDhaPCysPDhbDhaACysDhaKDhaCysNK

antiSMASH-DB 4.0 matches for thsA2

89.2%

NZ_CM000756.1and 17 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide

Lanthipeptides: BTHUR0011_RS14765_lanthipeptide

1

ESSGAGTPAITTAISAIIAATAQSPCPTSACSKSCNK

37

ESSGAGTPAI TAISA+ A TAQSPCPTSACSKSCNK

1

ESSGAGTPAIVTAISAVTAVTAQSPCPTSACSKSCNK

37

67.6%

NZ_JAGKQT010000007.1and 3 others:

NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09845_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05870_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05870_lanthipeptide

Lanthipeptides: J2M30_RS09845_lanthipeptide

6

GTPAITTAISAIIAATAQSPCPTSACSKSC

35

GTPAI +AISAI A T QSPCPTSACSKSC

1

GTPAIFSAISAITAVTVQSPCPTSACSKSC

30

48.7%

NZ_WHOM01000078.1and 1 other:

NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29290_lanthipeptide

Lanthipeptides: GCN81_RS29290_lanthipeptide

1

ESSGAG-TPAITTAISAIIAATA--QSPCPTSACSKSC

35

ES AG TP I A I+ A+A Q CPTS C+K C

2

ESLAAGITPTILPATGVIVGASAALQGGCPTSGCTKRC

39

with 69 more sequence matches

Only the first 10 are displayed here.

48.6%

NZ_CP086141.1and 1 other:

NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide

Lanthipeptides: LL065_RS24780_lanthipeptide

13

AISAIIA-ATAQSPC--PTSACSKSCNK

37

AISA +A ATA S TSAC+KSCNK

3

AISATVASATAVSALFTVTSACTKSCNK

30

48.6%

NZ_CP086141.1and 1 other:

NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide

Lanthipeptides: LL065_RS24780_lanthipeptide

10

ITTAISAIIA-ATAQSPC--PTSACSKSCNK

37

+ +AISA +A ATA S TSAC+KSCNK

4

VVSAISATVASATAVSALFTVTSACTKSCNK

34

45.2%

NZ_BNBJ01000003.1and 9 others:

NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05295_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptide

Lanthipeptides: IE304_RS05295_lanthipeptide

1

ESSGAG-TPAIT--TAISAII---AATAQSPCPTSACSKSC

35

ES AG TP I TA++ +I +A Q CPTS C+K C

2

ESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

43.2%

NZ_CP047645.1and 5 others:

NZ_CP047645.1 Lanthipeptides: GSN02_RS17435_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptide

Lanthipeptides: GSN02_RS17435_lanthipeptide

6

GTP--AITTAISA--IIAATAQSPCPTSACSKSCNK

37

GTP AI TA++ + + CPTSAC+ CNK

1

GTPVTAIITALTGTTFTVTLSAASCPTSACTNLCNK

36

43.2%

NZ_JALAUA010000003.1and 1 other:

NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04870_lanthipeptide

Lanthipeptides: MOD32_RS04870_lanthipeptide

6

GTP--AITTAISA--IIAATAQSPCPTSACSKSCNK

37

GTP AI TA++ + + CPTSAC+ CNK

1

GTPVTAILTALTGTTFTVTLSAASCPTSACTNLCNK

36

40.5%

NZ_CP015591.1and 15 others:

NZ_CP078085.1 Lanthipeptides: KU891_RS29355_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29350_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29345_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29340_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29335_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide

Lanthipeptides: A7A70_RS27550_lanthipeptide

7

TPAITTAISAIIAATAQSPCPTSACSKSC

35

TPA T + A IAAT S CPT+ C+ C

8

TPATPTIVEATIAATV-SICPTTKCTSRC

35

40.5%

NZ_JACSPO010000013.1and 1 other:

NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14885_lanthipeptide

Lanthipeptides: H9624_RS14885_lanthipeptide

5

AGTPAITTAISA-IIAATAQSP--CPTSACSKSC

35

AGT + AI +IA +A P CPT AC+ C

1

AGTTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

40.5%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

1

ESSGAGTPAITTAISAIIAATAQSPCPTSACS---KSCN

36

ES+ GTPA +S I CPT+ C+ +SCN

2

ESTPNGTPATIIPVSLAI-------CPTTRCASIVESCN

33

40.5%

NZ_QORY01000016.1and 1 other:

NZ_QORY01000016.1 Lanthipeptides: DT250_RS18265_lanthipeptide

Lanthipeptides: DT250_RS18265_lanthipeptide

3

SGAGTPAITTAISAIIAATAQSPCPTSACSKSC

35

SG TP TT AI + + CPT+ACS C

1

SGEVTP-YTTWGCAIFTIASAAQCPTTACSSKC

32

39.1%

NZ_JAJAGO010000028.1and 1 other:

NZ_JAJAGO010000028.1 Lanthipeptides: LHJ74_RS33595_lanthipeptide

Lanthipeptides: LHJ74_RS33595_lanthipeptide

1

ESSGAGTPAITTAISAIIAATAQSPCPTSACSKSC

35

E+ G +PA T++ + I AAT S CPTSACS C

13

EAFGGTSPATTSSWTCITAATI-SICPTSACSSKC

46

MIBiG 4.0 matches for thsA2

32.4%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

8

PAITTAISAIIAATA-------QSPCPTSACSKSC

35

PA+T I I+A A + CPT+ C+ C

3

PAVTGLILGIVAIQAGVAVGVSAAFCPTTKCTSRC

37

21.6%

BGC0002130.3 (QKI29070.1):

Lanthipeptide: cacaoidin

10

ITTAISAIIAATAQSPC

26

I ++SA I+ATA C

7

IYASVSASISATASWGC

23

11.8%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

1

ESSGAGTPAITT

12

ESS PA T

31

ESSRPAAPACHT

42

with 1 more sequence matches

10.8%

BGC0000581.6 (AAD28494.1):

Lasso peptide: microcin J25

4

GAGTP

8

G GTP

12

GIGTP

16

thsA2_

Leader:

MKEQKLEKITGLIPESELEEHLSGESSGAGTPAITTAISAIIGA

Core:

TAQSPCPTSACSKSCNK

Core with dehydrations:

DhbAQDhaPCysPDhbDhaACysDhaKDhaCysNK

antiSMASH-DB 4.0 matches for thsA2_

46.7%

NZ_JAGKQT010000007.1and 3 others:

NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09845_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05870_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05870_lanthipeptide

Lanthipeptides: J2M30_RS09845_lanthipeptide

1

TAQSPCPTSACSKSC

15

T QSPCPTSACSKSC

16

TVQSPCPTSACSKSC

30

45.9%

NZ_CM000756.1and 17 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide

Lanthipeptides: BTHUR0011_RS14765_lanthipeptide

1

TAQSPCPTSACSKSCNK

17

TAQSPCPTSACSKSCNK

21

TAQSPCPTSACSKSCNK

37

41.2%

NZ_CP061033.1and 1 other:

NZ_CP061033.1 Lanthipeptides: IAU67_RS09325_lanthipeptide

Lanthipeptides: IAU67_RS09325_lanthipeptide

6

CPTSACSKSC

15

CPTS C+ SC

7

CPTSGCTHSC

16

with 47 more sequence matches

Only the first 10 are displayed here.

41.2%

NZ_CP116355.1and 1 other:

NZ_CP116355.1 Lanthipeptides: KPP03845_RS17825_lanthipeptide

Lanthipeptides: KPP03845_RS17825_lanthipeptide

6

CPTSACSKSC

15

CPTS C+K C

1

CPTSGCTKRC

10

35.3%

NZ_BMVL01000013.1and 1 other:

NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28640_lanthipeptide

Lanthipeptides: IE257_RS28640_lanthipeptide

6

CPTSACSKSC

15

CPTS C+ C

1

CPTSGCTGRC

10

35.3%

NZ_GG657754.1and 1 other:

NZ_GG657754.1 Lanthipeptides: SSOG_RS27835_lanthipeptide

Lanthipeptides: SSOG_RS27835_lanthipeptide

6

CPTSACSKSC

15

CPTS C+ C

1

CPTSGCTSKC

10

35.3%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS31015_lanthipeptide

Lanthipeptides: CN325_RS31015_lanthipeptide

6

CPTSACSKSCN

16

CPTS C+ C

3

CPTSKCTTRCG

13

35.3%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS08060_lanthipeptide

Lanthipeptides: DEI99_RS08060_lanthipeptide

6

CPTSACSKSC

15

CPT AC+ C

8

CPTGACTSKC

17

35.0%

NZ_WITJ01000001.1and 1 other:

NZ_WITJ01000001.1 Lanthipeptides: GHI93_RS00070_lanthipeptide

Lanthipeptides: GHI93_RS00070_lanthipeptide

8

TSACSKSC

15

T+ACSKSC

10

TTACSKSC

17

33.3%

NZ_CP102975.1and 1 other:

NZ_FMOE01000002.1 Lanthipeptides: BJT27_RS07810_lanthipeptide

Lanthipeptides: NW953_RS00175_lanthipeptide

1

TAQSPCPTSACSKSCNK

17

TAQ CPT ACS C K

16

TAQ--CPTLACSSRCGK

30

30.0%

NZ_CP086141.1and 3 others:

NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptideNZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptideNZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide

Lanthipeptides: LL065_RS24780_lanthipeptide

8

TSACSKSCNK

17

TSAC+KSCNK

21

TSACTKSCNK

30

28.6%

NZ_CP115450.1and 1 other:

NZ_CP115450.1 Lanthipeptides: O1G21_RS35405_lanthipeptide

Lanthipeptides: O1G21_RS35405_lanthipeptide

6

CPTSACSKSC

15

CPT+AC+ C

12

CPTTACTSRC

21

28.0%

NZ_KI632509.1and 1 other:

NZ_KI632509.1 Lanthipeptides: AMYHA_RS26410_lanthipeptide

Lanthipeptides: AMYHA_RS26410_lanthipeptide

1

TAQSPCPTSAC

11

T QS CP S C

15

TCQSACPNSGC

25

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Identified secondary metabolite regions using strictness 'relaxed'

Legend:

Lanthipeptide(s) for thsM1

antiSMASH-DB 4.0 matches for thsA1

MIBiG 4.0 matches for thsA1

antiSMASH-DB 4.0 matches for thsA2

MIBiG 4.0 matches for thsA2

antiSMASH-DB 4.0 matches for thsA2_

Lanthipeptide(s) for thsM2

antiSMASH-DB 4.0 matches for thsA1

MIBiG 4.0 matches for thsA1

antiSMASH-DB 4.0 matches for thsA2

MIBiG 4.0 matches for thsA2

antiSMASH-DB 4.0 matches for thsA2_

Legend: