BGC0001399 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001399 (Aspergillus nidulans FGSC A4)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS	1	52,472	High	fellutamide B	NRPS:Type I

BGC0001399 - Region 1 - NRPS

Download region GenBank file

Download region SVG

Location: 1 - 52,472 nt. (total: 52,472 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 52,473
Label		BGC0001399

Tailoring functions

Oxidoreductases: oxygenase

ANIA_03497: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Ligases: ligase

ANIA_03490: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

ANIA_03495: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

ANIA_03496: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001399.4	0.97	NRPS	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001261.3	0.71	NRPS	AM-toxin	Alternaria alternata
BGC0002135.2	0.69	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001166.5	0.69	NRPS	HC-toxin	Alternaria jesenskae
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001240.4	0.67	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001833.4	0.67	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.66	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000307.4	0.65	NRPS	AbT1	Aureobasidium pullulans
BGC0002286.3	0.65	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001399.4	0.97	NRPS	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001261.3	0.71	NRPS	AM-toxin	Alternaria alternata
BGC0002135.2	0.69	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001166.5	0.69	NRPS	HC-toxin	Alternaria jesenskae
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001240.4	0.67	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001833.4	0.67	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.66	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000307.4	0.65	NRPS	AbT1	Aureobasidium pullulans
BGC0002286.3	0.65	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 52472:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Asn - Gln)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ANIA_03496: Asn - Gln

Search NORINE for peptide: strict or relaxed

AMP-binding (591..997): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVSNVGSIIK
Nearest Stachelhaus code(s):: Asn DVSNVGSIIK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1700..2097): Gln

nrpys: Gln

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAQNIAVINK
Nearest Stachelhaus code(s):: Gln DAQNIAVINK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ANIA_03495: Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (478..871): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DLYSAVAVVK
Nearest Stachelhaus code(s):: Leu DLYSAVAVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ANIA_03490: X

AMP-binding (45..464): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GLAYVGGVIK
Nearest Stachelhaus code(s):: nohBza GLGLVGAIIK (32% 8Å match); cycHexAla DLLSVGGVFK (29% 8Å match)
Stachelhaus code match:: 60% (weak)

Link to PARAS substrate predictor