BGC0001405 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001405 (Chaetomium globosum CBS 148.51)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	73,311	High	chaetoviridin E/11-epichaetomugilin A	PKS

BGC0001405 - Region 1 - T1PKS

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Location: 1 - 73,311 nt. (total: 73,311 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 73,312
Label		BGC0001405

Tailoring functions

Oxidoreductases: oxidase oxidoreductase

CHGG_07633: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

CHGG_07649: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

Transferases: halogenase

CHGG_07641: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
smcogs: SMCOG1119: halogenase

Ligases: synthase

CHGG_07638: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

CHGG_07645: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001405.4	1.12	PKS	chaetoviridin E, 11-epichaetomugilin A	Chaetomium globosum CBS 148.51
BGC0002608.2	1.05	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0002341.2	0.93	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0001284.4	0.61	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001244.3	0.59	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.59	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.59	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001258.3	0.56	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001257.3	0.56	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000107.3	0.56	PKS	naphthopyrone	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001405.4	1.00	PKS	chaetoviridin E, 11-epichaetomugilin A	Chaetomium globosum CBS 148.51
BGC0002608.2	0.80	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0002341.2	0.76	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001275.3	0.65	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000037.4	0.64	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0001268.4	0.64	NRPS, PKS	fusarin C	Fusarium fujikuroi

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 73311:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-pk) + (mal)
Non-colinear ordering:: CHGG_07638 + CHGG_07645 + CHGG_07646

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 48046:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 29695 - 73311:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal)
Non-colinear ordering:: CHGG_07645 + CHGG_07646

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CHGG_07638: pk

PKS_AT (557..921): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 63.9
Methoxymalonyl-CoA: 56.9
Malonyl-CoA: 51.8
Isobutyryl-CoA: 32.4
Ethylmalonyl-CoA: 32.2
Benzoyl-CoA: 20.5
trans-1,2-CPDA: 19.5
Propionyl-CoA: 15.5
fatty_acid: 9.3
CHC-CoA: 8.8
2-Methylbutyryl-CoA: 7.7
inactive: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

CHGG_07645: mal

PKS_AT (947..1175): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 75.8
Methoxymalonyl-CoA: 65.4
Methylmalonyl-CoA: 55.7
inactive: 55.3
Ethylmalonyl-CoA: 46.4
CHC-CoA: 26.0
Benzoyl-CoA: 25.6
Propionyl-CoA: 24.5
2-Methylbutyryl-CoA: 24.2
Isobutyryl-CoA: 23.7
trans-1,2-CPDA: 19.4
Acetyl-CoA: 18.7
fatty_acid: 18.0
3-Methylbutyryl-CoA: 10.0

Link to PARAS substrate predictor