BGC0001415: althiomycin biosynthetic gene cluster from Serratia marcescens subsp. marcescens Db11
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 2,414,944 - 2,445,231 nt. (total: 30,288 nt).
This entry is originally from NCBI GenBank HG326223.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001415
Short description althiomycin biosynthetic gene cluster from Serratia marcescens subsp. marcescens Db11
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
HG326223.1
2414944 - 2445231
via
Compounds
  • althiomycin
Species Serratia marcescens subsp. marcescens Db11 [taxonomy]
References
Chemical products information
althiomycin Evidence:
Copy SMILES
C16H17N5O6S2
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SMDB11_2288
  • CDG12863.1
 2414947 - 2415681 (-) putative thioesterase
    copy AA seq
    copy Nt seq
    • SMDB11_2289
    • CDG12864.1
    		 2415828 - 2431871 (-) non-ribosomal peptide synthetase
      copy AA seq
      copy Nt seq
      • SMDB11_2290
      • CDG12865.1
      		 2431874 - 2439004 (-) non-ribosomal peptide synthetase
        copy AA seq
        copy Nt seq
        • SMDB11_2291
        • CDG12866.1
        		 2439026 - 2439949 (-) hypothetical protein
          copy AA seq
          copy Nt seq
          • SMDB11_2292
          • CDG12867.1
          		 2439952 - 2440908 (-) hypothetical protein
            copy AA seq
            copy Nt seq
            • SMDB11_2293
            • CDG12868.1
            		 2441007 - 2442209 (-) putative drug efflux protein
              copy AA seq
              copy Nt seq
              • SMDB11_2294
              • CDG12869.1
              • bss
              		 2442494 - 2443843 (-) bacteriocin 28b
                copy AA seq
                copy Nt seq
                • SMDB11_2295
                • CDG12870.1
                		 2444149 - 2445228 (+) hypothetical protein
                  copy AA seq
                  copy Nt seq
                  Biosynthesis information

                  Biosynthetic modules

                  Name
                  Unk01
                  Type
                  nrps-type1
                  Genes
                  SMDB11_2289
                  Substrates
                  glycine (evidence: Structure-based inference, Sequence-based prediction)
                  Integrated Monomers
                  Domains
                  adenylation
                  Name
                  Unk02
                  Type
                  nrps-type1
                  Genes
                  SMDB11_2289
                  Substrates
                  cysteine (evidence: Structure-based inference, Sequence-based prediction)
                  Integrated Monomers
                  Domains
                  adenylation
                  Name
                  Unk03
                  Type
                  nrps-type1
                  Genes
                  SMDB11_2289
                  Substrates
                  serine (evidence: Structure-based inference, Sequence-based prediction)
                  Integrated Monomers
                  Domains
                  adenylation
                  Name
                  Unk04
                  Type
                  nrps-type1
                  Genes
                  SMDB11_2290
                  Substrates
                  cysteine (evidence: Structure-based inference, Sequence-based prediction)
                  Integrated Monomers
                  Domains
                  adenylation
                  Name
                  Unk05
                  Type
                  nrps-type1
                  Genes
                  SMDB11_2290
                  Substrates
                  glycine (evidence: Structure-based inference, Sequence-based prediction)
                  Integrated Monomers
                  Domains
                  adenylation
                  Annotation changelog

                  Entry version: 3

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-09-15
                  Cleaned up synonym list
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Added missing polyketide class
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Added NRP substrate specificities
                  • (ID: CUSGWVK3I4TVHJH7NHPFAP2L)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 2

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2019-10-16
                  Migrated from v1.4
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2019-10-16
                  Updated compound(s) information (MIBiG Annotathon)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2019-10-16
                  Updated compound(s) information (NPAtlas curation)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 1

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2016-09-03
                  Submitted
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  Detailed domain annotation
                  Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                  A domain glossary is available here, and an explanation of the visualisation is available here.
                  Selected features only
                  Show module domains
                  Similar known gene clusters from MIBiG 4.0
                  Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                  Click on reference genes to show details of similarities to genes within the current region.
                  Click on an accession to open that entry in the MiBIG database.