BGC0001419: myxochromide D biosynthetic gene cluster from Hyalangium minutum
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Location: 1 - 40,204 nt. (total: 40,204 nt).
This entry is originally from NCBI GenBank KX622589.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001419
Short description myxochromide D biosynthetic gene cluster from Hyalangium minutum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Iterative type I)
Loci
KX622589.1
via
Compounds
  • myxochromide D
Species Hyalangium minutum [taxonomy]
References
Chemical products information
myxochromide D Evidence: Mass spectrometry
Copy SMILES
C39H56N6O8
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • APZ78698.1
 1 - 2658 (+) uncharacterized protein
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    • APZ78699.1
    		 2668 - 3309 (-) uncharacterized protein
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      • APZ78700.1
      		 3475 - 3822 (+) pilus assembly protein PilZ
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        • APZ78701.1
        		 3898 - 5448 (-) amino acid dehydrogenase
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          • APZ78702.1
          • mchA
          		 6069 - 12569 (+) polyketide synthase
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            • APZ78703.1
            • mchB
            		 12566 - 21715 (+) nonribosomal peptide synthetase
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              • APZ78704.1
              • mchC
              		 21750 - 35150 (+) nonribosomal peptide synthetase
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                • APZ78705.1
                • mchD
                		 35147 - 35623 (+) membrane protein
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                  • APZ78706.1
                  		 35719 - 37035 (+) uncharacterized protein
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                    • APZ78707.1
                    		 37265 - 38014 (+) ABC transporter ATP-binding protein
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                      • APZ78708.1
                      		 38011 - 39402 (+) ABC transporter permease
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                        • APZ78709.1
                        		 39395 - 40204 (+) uncharacterized protein
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                          Biosynthesis information

                          Biosynthetic modules

                          Name
                          2
                          Type
                          nrps-type1
                          Genes
                          mchB
                          Substrates
                          threonine (evidence: Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          condensation (LCL), adenylation, methyltransferase
                          Name
                          3
                          Type
                          nrps-type1
                          Genes
                          mchB
                          Substrates
                          alanine (evidence: Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          condensation (LCL), adenylation, epimerase
                          Name
                          4
                          Type
                          nrps-type1
                          Genes
                          mchC
                          Substrates
                          leucine (evidence: Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          condensation (DCL), adenylation
                          Name
                          6
                          Type
                          nrps-type1
                          Genes
                          mchC
                          Substrates
                          alanine (evidence: Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          condensation (LCL), adenylation
                          Name
                          7
                          Type
                          nrps-type1
                          Genes
                          mchC
                          Substrates
                          glutamine (evidence: Sequence-based prediction)
                          Integrated Monomers
                          Domains
                          condensation (LCL), adenylation
                          Name
                          1
                          Type
                          pks-modular
                          Genes
                          mchA
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                          Annotation changelog

                          Entry version: 3

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-09-15
                          Corrected NRP module activity
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Removed gene annotations, including 'extra' genes, which duplicated NCBI annotations
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Changed gene identifiers used to consistently be 'gene' names
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Changed amino acid substrates to lower case
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 2

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2019-10-16
                          Migrated from v1.4
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 1

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2018-08-06
                          Submitted
                          • (ID: W3AST4BMPVTIWZ3NNIXB2T6Y)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          Detailed domain annotation
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