BGC0001432: myxochromide D biosynthetic gene cluster from Stigmatella erecta
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Location: 1 - 42,417 nt. (total: 42,417 nt).
This entry is originally from NCBI GenBank KX622602.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001432
Short description myxochromide D biosynthetic gene cluster from Stigmatella erecta
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Iterative type I)
Loci
KX622602.1
via
Compounds
  • myxochromide D
Species Stigmatella erecta [taxonomy]
References
Chemical products information
myxochromide D Evidence: NMR, Mass spectrometry, Chemical derivatisation
Copy SMILES
C38H54N6O8
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • APZ78852.1
 1 - 4167 (-) polyketide synthase
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    • APZ78853.1
    		 4391 - 5236 (+) polyketide synthase
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      • APZ78854.1
      • mchA
      		 5455 - 11952 (+) polyketide synthase
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        • APZ78855.1
        • mchB
        		 11949 - 21122 (+) nonribosomal peptide synthetase
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          • APZ78856.1
          • mchC
          		 21157 - 34566 (+) nonribosomal peptide synthetase
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            • APZ78857.1
            • mchD
            		 34563 - 35036 (+) membrane protein
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              • APZ78858.1
              		 35317 - 42417 (+) polyketide synthase
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                Biosynthesis information

                Biosynthetic modules

                Name
                2
                Type
                nrps-type1
                Genes
                mchB
                Substrates
                threonine (evidence: Structure-based inference)
                Integrated Monomers
                Domains
                condensation (LCL), adenylation, methyltransferase
                Name
                3
                Type
                nrps-type1
                Genes
                mchB
                Substrates
                alanine (evidence: Structure-based inference)
                Integrated Monomers
                Domains
                condensation (LCL), adenylation, epimerase
                Name
                4
                Type
                nrps-type1
                Genes
                mchC
                Substrates
                leucine (evidence: Structure-based inference)
                Integrated Monomers
                Domains
                condensation (DCL), adenylation
                Name
                6
                Type
                nrps-type1
                Genes
                mchC
                Substrates
                alanine (evidence: Structure-based inference)
                Integrated Monomers
                Domains
                condensation (LCL), adenylation
                Name
                7
                Type
                nrps-type1
                Genes
                mchC
                Substrates
                glutamine (evidence: Structure-based inference)
                Integrated Monomers
                Domains
                condensation (LCL), adenylation
                Name
                1
                Type
                pks-modular
                Genes
                mchA
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
                Annotation changelog

                Entry version: 3

                Date
                Changes
                Submitters
                Reviewers
                2022-09-15
                Corrected NRP module activity
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Removed gene annotations, including 'extra' genes, which duplicated NCBI annotations
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Changed gene identifiers used to consistently be 'gene' names
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Changed amino acid substrates to lower case
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 2

                Date
                Changes
                Submitters
                Reviewers
                2019-10-16
                Migrated from v1.4
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 1

                Date
                Changes
                Submitters
                Reviewers
                2018-08-06
                Submitted
                • (ID: W3AST4BMPVTIWZ3NNIXB2T6Y)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                Detailed domain annotation
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