BGC0001435 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001435 (Streptomyces sp. ZJ306)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS,lassopeptide	1	36,760	albusnodin	RiPP	75%

BGC0001435 - Region 1 - NRPS,T1PKS,lassopeptide

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Location: 1 - 36,760 nt. (total: 36,760 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Lasso peptides

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 36,761
Label		BGC0001435

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001435.1	1.92	NRP, Polyketide	ikarugamycin	Streptomyces sp. ZJ306
BGC0002006.1	1.29	RiPP	albusnodin	Streptomyces albus
BGC0001540.1	0.96	Other	CC-1065	Streptomyces zelensis
BGC0001493.1	0.80	RiPP	achromosin	Streptomyces achromogenes subsp. achromogenes
BGC0001548.1	0.80	RiPP	citrulassin A	Streptomyces albulus
BGC0001307.1	0.79	RiPP	chaxapeptin	Streptomyces leeuwenhoekii
BGC0001549.1	0.67	RiPP	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0001550.1	0.67	RiPP	citrulassin D	Streptomyces katrae
BGC0001552.1	0.66	RiPP	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000575.1	0.65	RiPP	lariatin	Rhodococcus jostii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001435.1	0.94	NRP, Polyketide	ikarugamycin	Streptomyces sp. ZJ306
BGC0002006.1	0.74	RiPP	albusnodin	Streptomyces albus
BGC0001909.1	0.66	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001540.1	0.65	Other	CC-1065	Streptomyces zelensis
BGC0001068.1	0.63	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001493.1	0.60	RiPP	achromosin	Streptomyces achromogenes subsp. achromogenes
BGC0001548.1	0.60	RiPP	citrulassin A	Streptomyces albulus
BGC0001307.1	0.60	RiPP	chaxapeptin	Streptomyces leeuwenhoekii
BGC0001280.1	0.59	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.59	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae

Similar known gene clusters

Lasso peptide predictions

Lassopeptide(s) for allorf_18910_19188

allorf_18910_19188

Leader:

CDGRAAQTPGNLARGARGRRTVMDIHTETNEIEAPMVVDLGELVALTL

Full core:

GQGKGSSEDKRRAYNHH

Putative macrolactam:

GQGKGSSED

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Module view

Legend

Lasso peptides

NRPS/PKS products

NRPS/PKS monomers

Core peptide predictions

allorf_18910_19188 - Class II: Cleavage pHMM score: 1.10; RODEO score: 16; Monoisotopic mass: 1907.9 Da; Molecular weight: 1909.0 Da; Number of bridges: 0

Predicted core structure(s)

For candidate cluster 1, location 0 - 32785:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ccmal - orn)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

AJD77023.1

Search NORINE for peptide: strict or relaxed

PKS_AT (555..852): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; Methylmalonyl-CoA: 62.5%; CE-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 121.0
Methylmalonyl-CoA: 117.1
Methoxymalonyl-CoA: 107.1
Ethylmalonyl-CoA: 106.7
Isobutyryl-CoA: 83.6
2-Methylbutyryl-CoA: 69.7
Propionyl-CoA: 68.2
Benzoyl-CoA: 66.3
Acetyl-CoA: 66.2
CHC-CoA: 56.4
trans-1,2-CPDA: 45.8
fatty_acid: 43.0
3-Methylbutyryl-CoA: 40.0
inactive: 31.6

AMP-binding (2301..2707): orn

NRPSPredictor2: orn

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: orn, lys, arg
Small clusters prediction:: orn, horn
Single AA prediction:: orn

Stachelhaus prediction details:

Stachelhaus sequence:: DVGEIGSIDK
Nearest Stachelhaus code:: orn
Stachelhaus code match:: 100% (strong)