Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001435.1:
Cluster 1NRP / Polyketide136760

BGC0001435, ikarugamycin biosynthetic gene cluster from Streptomyces sp. ZJ306. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: ikarugamycin
PubChem ID: 101647494
SMILES string: Copy to clipboard
Molecular formula: C29H38N2O4
Average molecular mass: 478.633 Da
Molecular activity: Antibacterial, Antifungal

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
Type I
Release / cyclization type:
Hydrolysis

Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Iterative type I
Starter unit:
Malonyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
AJD77023.1
Iterative PKS subtype:
Partially reducing
6
Thioesterase type:
Type I
Release / cyclization type:
Hydrolysis

Gene cluster description

ikarugamycin (BGC0001435). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank KF954512, positions 1-36760. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression
MIxS-compliance:Unknown
Comments:Please note that I was not involved in the studies on the mechanism and genes involved in the biosynthesis of Ikarugamycin, I am submitting this entry as part of study on the evolution of polycyclic tetramate macromalctams.
Contact for this cluster:Pablo Cruz Morales (University of Queensland/Langebio-CINVESTAV)

Literature references

1. Antosch J et al. (2014) Heterologous reconstitution of ikarugamycin biosynthesis in E. coli. Angew Chem Int Ed Engl 53(11):3011-4. doi: 10.1002/anie.201310641.
2. Zhang G et al. (2014) Mechanistic insights into polycycle formation by reductive cyclization in ikarugamycin biosynthesis. Angew Chem Int Ed Engl 53(19):4840-4. doi: 10.1002/anie.201402078.