BGC0001440: cystargolide A biosynthetic gene cluster from Kitasatospora cystarginea
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Location: 1 - 13,771 nt. (total: 13,771 nt).
This entry is originally from NCBI GenBank KY249117.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001440
Short description cystargolide A biosynthetic gene cluster from Kitasatospora cystarginea
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (other)
Loci
KY249117.1
via Knock-out studies, Enzymatic assays
Compounds
  • cystargolide A
  • cystargolide B
Species Kitasatospora cystarginea [taxonomy]
References
Chemical products information
cystargolide A Evidence: NMR, Mass spectrometry
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C18H30N2O6
Chemical database entries
NPAtlas
PubCHEM
cystargolide B Evidence: NMR, Mass spectrometry
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C17H28N2O6
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ARO49558.1
 1 - 861 (+) alpha/beta hydrolase
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    • ARO49559.1
    • cysA
    		 925 - 2577 (-) 2-IPM synthase
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      • ARO49560.1
      • cysB
      		 2574 - 4013 (-) MFS transporter
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        • ARO49561.1
        • cysC
        		 4010 - 5188 (-) AMP-dependent synthetase
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          • ARO49562.1
          • cysD
          		 5185 - 6186 (-) ATP-dependent carboxylate-amide ligase
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            • ARO49563.1
            • cysE
            		 6203 - 7018 (-) methylesterase
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              • ARO49564.1
              • cysF
              		 7011 - 8486 (-) AMP-dependent synthetase
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                • ARO49565.1
                • cysG
                		 8544 - 9230 (-) SAM-dependent methyltransferase
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                  • ARO49566.1
                  • cysH
                  		 9431 - 10360 (-) LysR family transcription regulator
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                    • ARO49567.1
                    		 12743 - 13771 (-) 3-oxoacyl-ACP synthase
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                      Biosynthesis information
                      Annotation changelog

                      Entry version: 4

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-10-07
                      Update chemical activity to schema version 2.11
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 3

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-09-15
                      Updated bioactivity data
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2019-10-16
                      Migrated from v1.4
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2019-10-16
                      Updated compound(s) information (NPAtlas curation)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2018-08-06
                      Submitted
                      • (ID: 4ACA66D6INRVNJRPWB3JQW5E)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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