BGC0001442: actinonin biosynthetic gene cluster from Streptomyces sp. strain ATCC 14903
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Location: 1 - 32,297 nt. (total: 32,297 nt).
This entry is originally from NCBI GenBank KY906183.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001442
Short description actinonin biosynthetic gene cluster from Streptomyces sp. strain ATCC 14903
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
KY906183.1
via
Compounds
  • actinonin
Species Streptomyces sp. strain ATCC 14903 [taxonomy]
References
Chemical products information
actinonin Evidence: NMR, Mass spectrometry
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C19H35N3O5
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ATJ33995.1
 1 - 1017 (+) LacI family transcription regulator
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    • ATJ33996.1
    		 1116 - 2402 (+) MFS transporter
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      • ATJ33997.1
      		 2483 - 4306 (+) beta-glucosidase
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        • ATJ33998.1
        • actA
        		 4382 - 6415 (-) dipeptidyl-peptidase
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          • ATJ33999.1
          • actB
          		 6598 - 8259 (+) ABC transporter
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            • ATJ34000.1
            • actC
            		 8266 - 8721 (-) methylmalonyl-CoA epimerase
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              • ATJ34001.1
              • actD
              		 8790 - 10232 (-) methylmalonyl-CoA mutase
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                • ATJ34002.1
                • actE
                		 10225 - 14991 (-) non-ribosomal peptide synthetase
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                  • ATJ34003.1
                  • actF
                  		 15270 - 16595 (-) crotonyl-CoA reductase
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                    • ATJ34004.1
                    • actG
                    		 16764 - 19844 (-) non-ribosomal peptide synthetase
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                      • ATJ34005.1
                      • actH
                      		 19894 - 21408 (-) adenylation domain-containing protein
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                        • ATJ34006.1
                        • actI
                        		 21867 - 22886 (+) AurF-like N-oxygenase
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                          • ATJ34007.1
                          • actJ
                          		 23019 - 24875 (+) asparagine synthetase B
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                            • ATJ34008.1
                            • actK
                            		 24872 - 26260 (+) amidase
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                              • ATJ34009.1
                              • actL
                              		 26392 - 27000 (-) TetR family transcription regulator
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                                • ATJ34010.1
                                		 27284 - 28852 (+) MFS transporter
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                                  • ATJ34011.1
                                  		 29180 - 31240 (-) short-chain dehydrogenase
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                                    • ATJ34012.1
                                    		 31737 - 32297 (+) membrane protein
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                                      Biosynthesis information

                                      Biosynthetic modules

                                      Name
                                      1
                                      Type
                                      nrps-type1
                                      Genes
                                      actH
                                      Substrates
                                      threonine (evidence: Sequence-based prediction)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      2
                                      Type
                                      nrps-type1
                                      Genes
                                      actE
                                      Substrates
                                      proline (evidence: Sequence-based prediction)
                                      Integrated Monomers
                                      Domains
                                      condensation (LCL), adenylation
                                      Annotation changelog

                                      Entry version: 4

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-10-07
                                      Update chemical activity to schema version 2.11
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 3

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-09-15
                                      Corrected NRP module activity
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-09-15
                                      Updated bioactivity data
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-09-15
                                      Updated NRP substrate specificities
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 2

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2019-10-16
                                      Migrated from v1.4
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2019-10-16
                                      Updated compound(s) information (NPAtlas curation)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 1

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2018-08-06
                                      Submitted
                                      • (ID: 4ACA66D6INRVNJRPWB3JQW5E)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      Detailed domain annotation
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