BGC0001442: actinonin biosynthetic gene cluster from Streptomyces sp. strain ATCC 14903
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Location: 1 - 32,297 nt. (total: 32,297 nt).
This entry is originally from NCBI GenBank KY906183.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001442
Short description actinonin biosynthetic gene cluster from Streptomyces sp. strain ATCC 14903
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: KY906183.1
Compounds
  • actinonin
Species Streptomyces sp. strain ATCC 14903 [taxonomy]
References
Chemical products information
actinonin
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C19H35N3O5
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ATJ33995.1
 1 - 1017 (+) LacI family transcription regulator
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  • ATJ33996.1
 1116 - 2402 (+) MFS transporter
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  • ATJ33997.1
 2483 - 4306 (+) beta-glucosidase
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  • ATJ33998.1
  • actA
 4382 - 6415 (-) dipeptidyl-peptidase
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  • ATJ33999.1
  • actB
 6598 - 8259 (+) ABC transporter
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  • ATJ34000.1
  • actC
 8266 - 8721 (-) methylmalonyl-CoA epimerase
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  • ATJ34001.1
  • actD
 8790 - 10232 (-) methylmalonyl-CoA mutase
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  • ATJ34002.1
  • actE
 10225 - 14991 (-) non-ribosomal peptide synthetase
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  • ATJ34003.1
  • actF
 15270 - 16595 (-) crotonyl-CoA reductase
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  • ATJ34004.1
  • actG
 16764 - 19844 (-) non-ribosomal peptide synthetase
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  • ATJ34005.1
  • actH
 19894 - 21408 (-) adenylation domain-containing protein
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  • ATJ34006.1
  • actI
 21867 - 22886 (+) AurF-like N-oxygenase
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  • ATJ34007.1
  • actJ
 23019 - 24875 (+) asparagine synthetase B
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  • ATJ34008.1
  • actK
 24872 - 26260 (+) amidase
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  • ATJ34009.1
  • actL
 26392 - 27000 (-) TetR family transcription regulator
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  • ATJ34010.1
 27284 - 28852 (+) MFS transporter
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  • ATJ34011.1
 29180 - 31240 (-) short-chain dehydrogenase
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  • ATJ34012.1
 31737 - 32297 (+) membrane protein
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
actH
Module 1
Specificity: threonine
Evidence for specificity:
  • Sequence-based prediction
actG
Module 0
Condensation domain type: LCL
actE
Module 2
Specificity: proline
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: 4ACA66D6INRVNJRPWB3JQW5E, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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