Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001442.1:
Cluster 1NRP132297

BGC0001442, actinonin biosynthetic gene cluster from Streptomyces sp. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: actinonin
PubChem ID: 443600
SMILES string: Copy to clipboard
Molecular formula: C19H35N3O5
Average molecular mass: 385.505 Da
Molecular activity: Inhibitor
Molecular target: metalloproteinase, bacterial peptide deformylase

Class-specific details

Biosynthetic class(es):
NRP
None (linear)
Thioesterase type:
Unknown
Release / cyclization type:
None

Nonribosomal peptide synthetases:
actH (ATJ34005.1)
Module 1
A specificity: Threonine
Evidence for specificity: Sequence-based prediction
C domain subtype: N/A
actG (ATJ34004.1)
Module 0
A specificity: None
Evidence for specificity: Sequence-based prediction
C domain subtype: LCL
actE (ATJ34002.1)
Module 2
A specificity: Proline
Evidence for specificity: Sequence-based prediction
C domain subtype: LCL

Gene cluster description

actinonin (BGC0001442). Gene Cluster 1. Biosynthetic class = NRP. GenBank KY906183, positions 1-32297. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction, Other
MIxS-compliance:Unknown
Contact for this cluster:Leonard Kaysser (University of Tuebingen)

Literature references

1. GORDON JJ et al. (1962) Actinonin: an antibiotic substance produced by an actinomycete. Nature 195:701-2.
2. Ngo HP et al. (2016) Crystal Structures of Peptide Deformylase from Rice Pathogen Xanthomonas oryzae pv. oryzae in Complex with Substrate Peptides, Actinonin, and Fragment Chemical Compounds. J Agric Food Chem 64(39):7307-7314. doi: 10.1021/acs.jafc.6b02976.
3. Gao J et al. (2016) Ligand and Structure-Based Approaches for the Identification of Peptide Deformylase Inhibitors as Antibacterial Drugs. LID - 10.3390/ijms17071141 [doi] LID - E1141 [pii] Int J Mol Sci 17(7). pii: ijms17071141. doi: 10.3390/ijms17071141.