BGC0001447 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001447 (Saccharomonospora azurea SZMC 14600)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	112,681	ebelactone	Polyketide	11%

BGC0001447 - Region 1 - T1PKS

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Location: 1 - 112,681 nt. (total: 112,681 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 112,682
Label		BGC0001447

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001447.1	0.70	Polyketide	primycin	Saccharomonospora azurea SZMC 14600
BGC0001164.1	0.32	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000041.1	0.29	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001858.1	0.29	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000067.1	0.27	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000046.1	0.27	Polyketide	depudecin	Alternaria brassicicola
BGC0000018.1	0.27	Polyketide	angolamycin	Streptomyces eurythermus
BGC0001280.1	0.26	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.26	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0002057.1	0.26	Polyketide	pateamine	Kiritimatiellaeota bacterium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001447.1	0.90	Polyketide	primycin	Saccharomonospora azurea SZMC 14600
BGC0001164.1	0.65	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000041.1	0.63	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001858.1	0.63	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000067.1	0.60	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000046.1	0.60	Polyketide	depudecin	Alternaria brassicicola
BGC0000018.1	0.60	Polyketide	angolamycin	Streptomyces eurythermus
BGC0001280.1	0.60	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.60	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0002057.1	0.59	Polyketide	pateamine	Kiritimatiellaeota bacterium

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 231 - 112681:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal - ohmal - redmal - ohmal) + (Me-ccmal - Me-ohmal - Me-ccmal) + (redmal) + (redmal - ohmal) + (ohmal - ohmal - ohmal - ohmal) + (Me-redmal) + (ohemal)
Non-colinear ordering:: SZMC14600_23480 + SZMC14600_23450 + SZMC14600_23460 + SZMC14600_23465 + SZMC14600_23470 + SZMC14600_23485 + SZMC14600_23490

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

SZMC14600_23445

PKS_AT (47..252): pk

ATSignature: (unknown)

No matches above 50%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

SZMC14600_23450

PKS_AT (665..962): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 214.7
Ethylmalonyl-CoA: 208.4
Methoxymalonyl-CoA: 175.4
2-Methylbutyryl-CoA: 147.1
trans-1,2-CPDA: 124.1
CHC-CoA: 117.9
Propionyl-CoA: 114.7
Malonyl-CoA: 88.1
Isobutyryl-CoA: 70.3
Benzoyl-CoA: 51.6
3-Methylbutyryl-CoA: 46.8
Acetyl-CoA: 41.7
fatty_acid: 34.1
inactive: 19.3

PKS_AT (2339..2631): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 206.4
Ethylmalonyl-CoA: 199.6
Methoxymalonyl-CoA: 166.5
2-Methylbutyryl-CoA: 135.1
Propionyl-CoA: 111.3
trans-1,2-CPDA: 99.8
Malonyl-CoA: 90.0
CHC-CoA: 90.0
Isobutyryl-CoA: 70.4
Benzoyl-CoA: 56.3
Acetyl-CoA: 54.2
fatty_acid: 52.2
inactive: 31.5
3-Methylbutyryl-CoA: 27.6

PKS_AT (3865..4157): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 186.8
Ethylmalonyl-CoA: 167.1
Methoxymalonyl-CoA: 147.7
2-Methylbutyryl-CoA: 116.9
trans-1,2-CPDA: 109.3
Propionyl-CoA: 99.7
CHC-CoA: 80.2
Malonyl-CoA: 77.7
Isobutyryl-CoA: 55.4
Benzoyl-CoA: 50.8
Acetyl-CoA: 38.1
fatty_acid: 31.9
inactive: 25.1
3-Methylbutyryl-CoA: 12.0

SZMC14600_23460

PKS_AT (559..831): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 211.3
inactive: 118.1
Methoxymalonyl-CoA: 58.4
Methylmalonyl-CoA: 54.7
Isobutyryl-CoA: 39.1
Propionyl-CoA: 23.9
Acetyl-CoA: 22.1
Benzoyl-CoA: 19.8
CHC-CoA: 14.2
fatty_acid: 13.4
Ethylmalonyl-CoA: 11.5
2-Methylbutyryl-CoA: 11.3
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

SZMC14600_23465

PKS_AT (701..973): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 206.4
inactive: 113.6
Methoxymalonyl-CoA: 57.5
Methylmalonyl-CoA: 51.5
Isobutyryl-CoA: 34.7
Propionyl-CoA: 24.1
Benzoyl-CoA: 22.6
Acetyl-CoA: 19.2
CHC-CoA: 18.7
Ethylmalonyl-CoA: 18.6
2-Methylbutyryl-CoA: 14.0
fatty_acid: 13.4
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2689..2971): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 213.4
inactive: 124.7
Methoxymalonyl-CoA: 68.6
Methylmalonyl-CoA: 64.5
Isobutyryl-CoA: 35.4
Propionyl-CoA: 33.8
2-Methylbutyryl-CoA: 25.2
Benzoyl-CoA: 24.3
Acetyl-CoA: 19.8
Ethylmalonyl-CoA: 18.2
CHC-CoA: 17.2
fatty_acid: 13.6
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

SZMC14600_23470

PKS_AT (555..828): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 213.7
inactive: 117.3
Methoxymalonyl-CoA: 61.6
Methylmalonyl-CoA: 60.7
Isobutyryl-CoA: 34.1
Propionyl-CoA: 31.5
Benzoyl-CoA: 24.4
Acetyl-CoA: 20.3
Ethylmalonyl-CoA: 19.6
2-Methylbutyryl-CoA: 19.1
CHC-CoA: 17.8
fatty_acid: 13.5
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (1950..2232): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 91.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 219.9
inactive: 124.7
Methoxymalonyl-CoA: 72.6
Methylmalonyl-CoA: 61.8
Propionyl-CoA: 37.9
Isobutyryl-CoA: 36.0
Benzoyl-CoA: 27.6
Ethylmalonyl-CoA: 21.8
Acetyl-CoA: 21.8
fatty_acid: 20.9
2-Methylbutyryl-CoA: 15.9
CHC-CoA: 13.8
trans-1,2-CPDA: 10.3
3-Methylbutyryl-CoA: 0.0

PKS_AT (3415..3687): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 216.0
inactive: 119.5
Methoxymalonyl-CoA: 63.2
Methylmalonyl-CoA: 60.6
Isobutyryl-CoA: 39.7
Propionyl-CoA: 29.9
Benzoyl-CoA: 24.4
Ethylmalonyl-CoA: 24.2
CHC-CoA: 20.5
Acetyl-CoA: 19.5
2-Methylbutyryl-CoA: 18.3
fatty_acid: 14.3
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (4865..5156): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 225.6
inactive: 124.7
Methoxymalonyl-CoA: 78.5
Methylmalonyl-CoA: 73.0
Isobutyryl-CoA: 48.8
Propionyl-CoA: 35.1
Benzoyl-CoA: 29.2
Ethylmalonyl-CoA: 23.2
Acetyl-CoA: 19.7
fatty_acid: 17.1
2-Methylbutyryl-CoA: 16.7
CHC-CoA: 13.1
trans-1,2-CPDA: 11.1
3-Methylbutyryl-CoA: 0.0

SZMC14600_23480

PKS_AT (1..185): mmal

ATSignature: (unknown)

No matches above 50%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 95.6
Ethylmalonyl-CoA: 79.4
Methoxymalonyl-CoA: 64.6
Propionyl-CoA: 39.6
2-Methylbutyryl-CoA: 39.3
Malonyl-CoA: 33.9
trans-1,2-CPDA: 33.6
Isobutyryl-CoA: 21.6
fatty_acid: 20.4
CHC-CoA: 18.6
Acetyl-CoA: 15.5
inactive: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (1563..1835): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 214.5
inactive: 118.5
Methoxymalonyl-CoA: 61.7
Methylmalonyl-CoA: 61.2
Isobutyryl-CoA: 40.1
Propionyl-CoA: 30.1
Benzoyl-CoA: 22.8
Ethylmalonyl-CoA: 22.2
2-Methylbutyryl-CoA: 20.3
Acetyl-CoA: 20.0
CHC-CoA: 18.2
fatty_acid: 13.5
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (3034..3319): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 221.2
inactive: 119.4
Methoxymalonyl-CoA: 61.4
Methylmalonyl-CoA: 57.6
Isobutyryl-CoA: 37.2
Propionyl-CoA: 24.8
Benzoyl-CoA: 23.5
Ethylmalonyl-CoA: 19.0
Acetyl-CoA: 15.6
CHC-CoA: 15.2
fatty_acid: 12.3
2-Methylbutyryl-CoA: 10.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (5013..5285): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 205.0
inactive: 113.3
Methoxymalonyl-CoA: 57.6
Methylmalonyl-CoA: 54.2
Isobutyryl-CoA: 35.6
Propionyl-CoA: 25.9
Benzoyl-CoA: 22.2
Acetyl-CoA: 21.9
Ethylmalonyl-CoA: 17.2
2-Methylbutyryl-CoA: 17.0
CHC-CoA: 16.5
fatty_acid: 13.0
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

SZMC14600_23485

PKS_AT (106..411): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 213.5
Ethylmalonyl-CoA: 211.4
Methoxymalonyl-CoA: 168.3
2-Methylbutyryl-CoA: 138.2
Propionyl-CoA: 119.7
trans-1,2-CPDA: 119.4
CHC-CoA: 108.0
Malonyl-CoA: 101.3
Isobutyryl-CoA: 69.1
Benzoyl-CoA: 52.6
Acetyl-CoA: 52.2
fatty_acid: 48.2
3-Methylbutyryl-CoA: 28.9
inactive: 28.8

SZMC14600_23490

PKS_AT (552..850): emal

ATSignature: Ethylmalonyl-CoA, Methylmalonyl-CoA, Methoxymalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 87.5%; Methylmalonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 197.4
Methylmalonyl-CoA: 194.2
Methoxymalonyl-CoA: 173.4
trans-1,2-CPDA: 128.5
2-Methylbutyryl-CoA: 118.6
CHC-CoA: 102.9
Propionyl-CoA: 94.2
Isobutyryl-CoA: 92.2
Malonyl-CoA: 88.7
Benzoyl-CoA: 78.7
Acetyl-CoA: 63.3
fatty_acid: 36.9
3-Methylbutyryl-CoA: 29.4
inactive: 17.9