BGC0001448: malacidin A biosynthetic gene cluster from uncultured bacterium
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Location: 1 - 72,298 nt. (total: 72,298 nt).
This entry is originally from NCBI GenBank KY654519.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001448
Short description malacidin A biosynthetic gene cluster from uncultured bacterium
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Ca+-dependent lipopeptide)
Loci NCBI GenBank: KY654519.1
Compounds
  • malacidin A
  • malacidin B
Species uncultured bacterium [taxonomy]
References
Chemical products information
malacidin A [synonyms: metagenomic acidic lipopeptide antibiotic a]
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C56H88N12O20
Chemical database entries
PubCHEM
ChEBI
malacidin B [synonyms: metagenomic acidic lipopeptide antibiotic b]
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C57H90N12O20
Chemical database entries
PubCHEM
ChEBI
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ARU08060.1
 1 - 459 (-) hypothetical protein
  • Unknown
Sequence-based prediction
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  • ARU08061.1
 459 - 1232 (-) hypothetical protein
  • Unknown
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  • ARU08062.1
 1271 - 2197 (-) hypothetical protein
  • Unknown
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  • ARU08063.1
  • mlcA
 2471 - 5602 (+) mlcA
  • Scaffold biosynthesis
Sequence-based prediction
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  • ARU08064.1
  • mlcB
 5593 - 6489 (+) mlcB
  • Regulation
Sequence-based prediction
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  • ARU08065.1
  • mlcC
 6507 - 7445 (+) mlcC
  • Regulation
Sequence-based prediction
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  • ARU08066.1
  • mlcD
 7504 - 8319 (-) mlcD
  • Transport
Sequence-based prediction
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  • ARU08067.1
  • mlcE
 8316 - 9533 (-) mlcE
  • Precursor biosynthesis
Sequence-based prediction
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  • ARU08068.1
  • mlcF
 9539 - 10012 (-) mlcF
  • Precursor biosynthesis
Sequence-based prediction
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  • ARU08069.1
  • mlcG
 10224 - 11987 (+) mlcG
  • Precursor biosynthesis
Sequence-based prediction
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  • ARU08070.1
  • mlcH
 11987 - 13420 (+) mlcH
  • Precursor biosynthesis
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  • ARU08071.1
  • mlcI
 13417 - 15012 (+) mlcI
  • Precursor biosynthesis
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  • ARU08072.1
  • mlcJ
 15023 - 15292 (+) mlcJ
  • Precursor biosynthesis
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  • ARU08073.1
  • mlcK
 15319 - 24513 (+) mlcK
  • Scaffold biosynthesis
Sequence-based prediction
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  • ARU08074.1
  • mlcL
 24510 - 41396 (+) mlcL
  • Scaffold biosynthesis
Sequence-based prediction
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  • ARU08075.1
  • mlcM
 41401 - 48243 (+) mlcM
  • Scaffold biosynthesis
Sequence-based prediction
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  • ARU08076.1
 48218 - 49435 (-) hypothetical protein
  • Unknown
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  • ARU08077.1
 49495 - 49689 (-) hypothetical protein
  • Unknown
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  • ARU08078.1
 49752 - 50345 (-) hypothetical protein
  • Unknown
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  • ARU08079.1
 50606 - 51100 (+) hypothetical protein
  • Unknown
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  • ARU08080.1
 51182 - 52045 (+) hypothetical protein
  • Unknown
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  • ARU08081.1
 52042 - 52446 (-) hypothetical protein
  • Unknown
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  • ARU08082.1
  • mlcN
 52469 - 53380 (-) mlcN
  • Regulation
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  • ARU08083.1
  • mlcO
 53377 - 54312 (-) mlcO
  • Transport
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  • ARU08084.1
  • mlcP
 54377 - 55243 (-) mlcP
  • Precursor biosynthesis
Sequence-based prediction
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  • ARU08085.1
 55242 - 55457 (+) hypothetical protein
  • Unknown
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  • ARU08086.1
  • mlcQ
 55515 - 56600 (-) mlcQ
  • Precursor biosynthesis
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  • ARU08087.1
  • mlcR
 56597 - 57397 (-) mlcR
  • Precursor biosynthesis
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  • ARU08088.1
  • mlcS
 57408 - 59663 (-) mlcS
  • Precursor biosynthesis
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  • ARU08089.1
  • mlcT
 59660 - 61381 (-) mlcT
  • Precursor biosynthesis
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  • ARU08090.1
  • mlcU
 62005 - 62271 (+) mlcU
  • Regulation
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  • ARU08091.1
  • mlcV
 62354 - 62572 (+) mlcV
  • Scaffold biosynthesis
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  • ARU08092.1
 62712 - 63257 (+) hypothetical protein
  • Unknown
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  • ARU08093.1
  • mlcW
 63298 - 63984 (+) mlcW
  • Regulation
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  • ARU08094.1
 64023 - 64817 (+) hypothetical protein
  • Unknown
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  • ARU08095.1
  • mlcX
 64814 - 65797 (+) mlcX
  • Precursor biosynthesis
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  • ARU08096.1
  • mlcY
 66442 - 69489 (+) mlcY
  • Regulation
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  • ARU08097.1
 69828 - 70919 (-) hypothetical protein
  • Unknown
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  • ARU08098.1
 70916 - 72298 (-) hypothetical protein
  • Unknown
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NRP-specific information
Subclass Ca+-dependent lipopeptide
Cyclic? yes
Lipid moiety methyl nonadienoic acid, methyl decadienoic acid
NRP-synthases
Gene Modules
mlcA
Module 2
Specificity: 2,3-diamino-3-methylpropanoic acid
Evidence for specificity:
  • Structure-based inference
mlcK
Module 1
Specificity: 3-methylaspartic acid
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Starter
Module 3
Condensation domain type: LCL
Module 4
Specificity: valine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
mlcL
Module 5
Specificity: lysine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
Module 6
Specificity: 3-hydroxyaspartic acid
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 7
Specificity: aspartic acid
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 8
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 9
Specificity: 3-methylaspartic acid
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
mlcM
Module 10
Specificity: valine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: DCL
Module 11
Specificity: 4R-methylproline
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: IE42ACYYGHZNO4BAWZY6ERNR, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed gene names of 'No gene ID'
  • Fixed duplicate gene names
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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