BGC0001449: ucs1025a biosynthetic gene cluster from Thermothelomyces thermophilus
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Location: 1,175,000 - 1,217,500 nt. (total: 42,501 nt).
This entry is originally from NCBI GenBank CP003004.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001449
Short description ucs1025a biosynthetic gene cluster from Thermothelomyces thermophilus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "Genetic and biochemical analysis revealed a a new strategy used by nature to construct heterocyclic alkaloid-like ring systems using assembly line logic."
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Iterative type I)
  • other (other)
Loci
CP003004.1
1175000 - 1217500
via Knock-out studies, Enzymatic assays, Heterologous expression
Compounds
  • ucs1025a
Species Thermothelomyces thermophilus [taxonomy]
References
Chemical products information
ucs1025a [synonyms: ucs-1025a, ucs 1025a] Evidence: Mass spectrometry [1], X-ray crystallography [1]
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C20H25N1O5
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • MYCTH_2303693
  • AEO57479.1
 1175898 - 1176863 (-) hypothetical protein
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    • MYCTH_2303695
    • AEO57480.1
    		 1179001 - 1180827 (+) hypothetical protein
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      • MYCTH_68164
      • AEO57481.1
      		 1181825 - 1194022 (-) PKS-NRPSs
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        • MYCTH_50128
        • AEO57482.1
        		 1195042 - 1195934 (+) methyltransferase-like protein
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          • MYCTH_115957
          • AEO57483.1
          		 1197173 - 1198357 (+) 2OG-Fe(II) oxygenase-like protein
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            • MYCTH_2303701
            • AEO57484.1
            		 1198891 - 1199634 (-) pyrroline-5-carboxylate reductase
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              • MYCTH_2303702
              • AEO57485.1
              		 1200562 - 1201868 (+) Diels-Alderase
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                • MYCTH_2138881
                • AEO57486.1
                		 1202910 - 1204496 (+) hypothetical protein
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                  • MYCTH_2303707
                  • AEO57487.1
                  		 1204928 - 1206041 (-) short chain dehydrogenase/reductase (SDR)
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                    • MYCTH_81364
                    • AEO57488.1
                    		 1206613 - 1208349 (+) p450
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                      • MYCTH_2303709
                      • AEO57489.1
                      		 1209400 - 1210866 (-) hydrolase
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                        • MYCTH_50920
                        • AEO57490.1
                        		 1211983 - 1213963 (+) general substrate transporter
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                          • MYCTH_48716
                          • AEO57491.1
                          		 1215630 - 1217022 (+) enoylreductase
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                            Biosynthesis information

                            Biosynthetic modules

                            Name
                            2
                            Type
                            nrps-type1
                            Genes
                            MYCTH_68164
                            Substrates
                            3S-methylproline (evidence: Feeding study)
                            Integrated Monomers
                            Domains
                            condensation (Starter), adenylation
                            Name
                            1
                            Type
                            pks-modular
                            Genes
                            MYCTH_68164
                            Substrates
                            Integrated Monomers
                            Domains
                            acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, methyltransferase
                            Annotation changelog

                            Entry version: next

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2024-05-14
                            MIBiG v4 annotathon
                            • (ID: 7DA2QLBWQP4AXXNZI5PHTAAU)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 4

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-10-07
                            Update chemical activity to schema version 2.11
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Corrected NRP module activity
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Updated NRP substrate specificities
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Migrated from v1.4
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2018-08-06
                            Submitted
                            • (ID: LETUUHCEOV6XPKOFSNBTL3D3)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            Detailed domain annotation
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