BGC0001461: nogabecin biosynthetic gene cluster from Amycolatopsis keratiniphila subsp. nogabecina
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Location: 97,566 - 165,358 nt. (total: 67,793 nt).
This entry is originally from NCBI GenBank MQUP01000022.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001461
Short description nogabecin biosynthetic gene cluster from Amycolatopsis keratiniphila subsp. nogabecina
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "nkaur@imtech.res.in\nmayil@imtech.res.in"
Biosynthetic class(es)
  • NRP (Glycopeptide)
Loci NCBI GenBank: MQUP01000022.1
Compounds
  • nogabecin
Species Amycolatopsis keratiniphila subsp. nogabecina [taxonomy]
References
Chemical products information
nogabecin
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BS330_28355
  • OLZ50880.1
 97566 - 98597 (+) lactate dehydrogenase
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  • BS330_28360
  • OLZ50881.1
 98599 - 99645 (+) D-alanine--(R)-lactate ligase
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  • BS330_28365
  • OLZ50882.1
 99635 - 100243 (+) D-Ala-D-Ala dipeptidase VanX
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  • BS330_28370
  • OLZ50883.1
 101518 - 102483 (+) streptomycin biosynthesis protein
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  • BS330_28375
  • OLZ50936.1
 102559 - 103443 (+) prephenate dehydrogenase
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  • BS330_28380
  • OLZ50884.1
 103580 - 105514 (+) ABC transporter
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  • BS330_28385
 105511 - 114923 (+) non-ribosomal peptide synthetase
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  • BS330_28390
  • OLZ50885.1
 115279 - 127464 (+) non-ribosomal peptide synthetase
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  • BS330_28395
  • OLZ50886.1
 127585 - 133179 (+) non-ribosomal peptide synthetase
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  • BS330_28400
  • OLZ50887.1
 133176 - 133385 (+) MbtH family protein
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  • BS330_28405
  • OLZ50937.1
 133508 - 134671 (+) cytochrome
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  • BS330_28410
  • OLZ50888.1
 134809 - 136005 (+) cytochrome
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  • BS330_28415
  • OLZ50889.1
 136123 - 137343 (+) cytochrome
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  • BS330_28420
  • OLZ50890.1
 137405 - 138880 (+) tryptophan halogenase
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  • BS330_28425
  • OLZ50891.1
 138933 - 140120 (+) glycosyl transferase
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  • BS330_28430
  • OLZ50892.1
 140154 - 141380 (+) glycosyl transferase
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  • BS330_28435
  • OLZ50893.1
 141432 - 142361 (+) methyltransferase
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  • BS330_28440
  • OLZ50894.1
 142401 - 143627 (+) glycosyl transferase
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  • BS330_28445
  • OLZ50895.1
 143690 - 144502 (+) PIG-L family deacetylase
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  • BS330_28450
  • OLZ50896.1
 144573 - 146444 (+) mannosyltransferase
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  • BS330_28455
  • OLZ50897.1
 146969 - 148255 (-) GntR family transcriptional regulator
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  • BS330_28460
  • OLZ50898.1
 148431 - 149261 (+) alpha/beta hydrolase
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  • BS330_28465
  • OLZ50899.1
 149258 - 150991 (+) non-ribosomal peptide synthetase
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  • BS330_28470
  • OLZ50900.1
 151006 - 152196 (+) NikQ protein
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  • BS330_28475
  • OLZ50901.1
 152307 - 153359 (+) 4-hydroxyphenylpyruvate dioxygenase
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  • BS330_28480
  • OLZ50902.1
 153356 - 154432 (+) alpha-hydroxy-acid oxidizing enzyme
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  • BS330_28485
  • OLZ50903.1
 154505 - 155851 (+) cation/H(+) antiporter
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  • BS330_28490
  • OLZ50938.1
 156063 - 157475 (+) NDP-hexose 2,3-dehydratase
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  • BS330_28495
  • OLZ50904.1
 157477 - 158454 (+) NAD-dependent epimerase/dehydratase
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  • BS330_28500
  • OLZ50905.1
 158451 - 159560 (+) daunorubicin biosynthesis sensory transduction protein DnrJ
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  • BS330_28505
  • OLZ50906.1
 159584 - 160201 (+) dTDP-4-dehydrorhamnose 3,5-epimerase
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  • BS330_28510
  • OLZ50907.1
 160356 - 161456 (+) type III polyketide synthase
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  • BS330_28515
  • OLZ50908.1
 161450 - 162112 (+) enoyl-CoA hydratase
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  • BS330_28520
  • OLZ50939.1
 162145 - 163323 (+) enoyl-CoA hydratase
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  • BS330_28525
  • OLZ50909.1
 163320 - 164111 (+) enoyl-CoA hydratase
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  • BS330_28530
  • OLZ50910.1
 164282 - 165358 (+) 3-deoxy-7-phosphoheptulonate synthase
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NRP-specific information
Subclass Glycopeptide
Cyclic? no
NRP-synthases
Gene Modules
BS330_28385
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: R-beta-hydroxytyrosine
Evidence for specificity:
  • Structure-based inference
BS330_28390
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: R-beta-hydroxytyrosine
Evidence for specificity:
  • Structure-based inference
BS330_28395
Module ?
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
BS330_28465
Module ?
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: UZDMKOBVVEVI67YDKBV3PKAC, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: 3UOU7PODQJXIM6BEPUHHRRA5, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Remove negative molecular mass
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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