BGC0001461: Actinoidin B biosynthetic gene cluster from Amycolatopsis keratiniphila subsp. nogabecina
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Location: 97,566 - 165,358 nt. (total: 67,793 nt).
This entry is originally from NCBI GenBank MQUP01000022.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001461
Short description Actinoidin B biosynthetic gene cluster from Amycolatopsis keratiniphila subsp. nogabecina
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "nkaur@imtech.res.in\nmayil@imtech.res.in"
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MQUP01000022.1
97566 - 165358
via
Compounds
  • Actinoidin B
Species Amycolatopsis keratiniphila subsp. nogabecina [taxonomy]
References
Chemical products information
Actinoidin B [synonyms: Nogabecin] Evidence: Mass spectrometry [1]
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C84H93Cl2N9O31
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BS330_28355
  • OLZ50880.1
 97566 - 98597 (+) lactate dehydrogenase
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    • BS330_28360
    • OLZ50881.1
    		 98599 - 99645 (+) D-alanine--(R)-lactate ligase
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      • BS330_28365
      • OLZ50882.1
      		 99635 - 100243 (+) D-Ala-D-Ala dipeptidase VanX
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        • BS330_28370
        • OLZ50883.1
        		 101518 - 102483 (+) streptomycin biosynthesis protein
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          • BS330_28375
          • OLZ50936.1
          		 102559 - 103443 (+) prephenate dehydrogenase
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            • BS330_28380
            • OLZ50884.1
            		 103580 - 105514 (+) ABC transporter
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              • BS330_28385
              		 105511 - 114923 (+) non-ribosomal peptide synthetase
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                • BS330_28390
                • OLZ50885.1
                		 115279 - 127464 (+) non-ribosomal peptide synthetase
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                  • BS330_28395
                  • OLZ50886.1
                  		 127585 - 133179 (+) non-ribosomal peptide synthetase
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                    • BS330_28400
                    • OLZ50887.1
                    		 133176 - 133385 (+) MbtH family protein
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                      • BS330_28405
                      • OLZ50937.1
                      		 133508 - 134671 (+) cytochrome
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                        • BS330_28410
                        • OLZ50888.1
                        		 134809 - 136005 (+) cytochrome
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                          • BS330_28415
                          • OLZ50889.1
                          		 136123 - 137343 (+) cytochrome
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                            • BS330_28420
                            • OLZ50890.1
                            		 137405 - 138880 (+) tryptophan halogenase
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                              • BS330_28425
                              • OLZ50891.1
                              		 138933 - 140120 (+) glycosyl transferase
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                                • BS330_28430
                                • OLZ50892.1
                                		 140154 - 141380 (+) glycosyl transferase
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                                  • BS330_28435
                                  • OLZ50893.1
                                  		 141432 - 142361 (+) methyltransferase
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                                    • BS330_28440
                                    • OLZ50894.1
                                    		 142401 - 143627 (+) glycosyl transferase
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                                      • BS330_28445
                                      • OLZ50895.1
                                      		 143690 - 144502 (+) PIG-L family deacetylase
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                                        • BS330_28450
                                        • OLZ50896.1
                                        		 144573 - 146444 (+) mannosyltransferase
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                                          • BS330_28455
                                          • OLZ50897.1
                                          		 146969 - 148255 (-) GntR family transcriptional regulator
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                                            • BS330_28460
                                            • OLZ50898.1
                                            		 148431 - 149261 (+) alpha/beta hydrolase
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                                              • BS330_28465
                                              • OLZ50899.1
                                              		 149258 - 150991 (+) non-ribosomal peptide synthetase
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                                                • BS330_28470
                                                • OLZ50900.1
                                                		 151006 - 152196 (+) NikQ protein
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                                                  • BS330_28475
                                                  • OLZ50901.1
                                                  		 152307 - 153359 (+) 4-hydroxyphenylpyruvate dioxygenase
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                                                    • BS330_28480
                                                    • OLZ50902.1
                                                    		 153356 - 154432 (+) alpha-hydroxy-acid oxidizing enzyme
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                                                      • BS330_28485
                                                      • OLZ50903.1
                                                      		 154505 - 155851 (+) cation/H(+) antiporter
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                                                        • BS330_28490
                                                        • OLZ50938.1
                                                        		 156063 - 157475 (+) NDP-hexose 2,3-dehydratase
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                                                          • BS330_28495
                                                          • OLZ50904.1
                                                          		 157477 - 158454 (+) NAD-dependent epimerase/dehydratase
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                                                            • BS330_28500
                                                            • OLZ50905.1
                                                            		 158451 - 159560 (+) daunorubicin biosynthesis sensory transduction protein DnrJ
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                                                              • BS330_28505
                                                              • OLZ50906.1
                                                              		 159584 - 160201 (+) dTDP-4-dehydrorhamnose 3,5-epimerase
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                                                                • BS330_28510
                                                                • OLZ50907.1
                                                                		 160356 - 161456 (+) type III polyketide synthase
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                                                                  • BS330_28515
                                                                  • OLZ50908.1
                                                                  		 161450 - 162112 (+) enoyl-CoA hydratase
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                                                                    • BS330_28520
                                                                    • OLZ50939.1
                                                                    		 162145 - 163323 (+) enoyl-CoA hydratase
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                                                                      • BS330_28525
                                                                      • OLZ50909.1
                                                                      		 163320 - 164111 (+) enoyl-CoA hydratase
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                                                                        • BS330_28530
                                                                        • OLZ50910.1
                                                                        		 164282 - 165358 (+) 3-deoxy-7-phosphoheptulonate synthase
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                                                                          Biosynthesis information

                                                                          Biosynthetic modules

                                                                          Name
                                                                          Unk01
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          BS330_28385
                                                                          Substrates
                                                                          4-hydroxyphenylglycine (evidence: Structure-based inference [2])
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Name
                                                                          Unk02
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          BS330_28385
                                                                          Substrates
                                                                          R-beta-hydroxytyrosine (evidence: Structure-based inference [2])
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Name
                                                                          Unk03
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          BS330_28390
                                                                          Substrates
                                                                          4-hydroxyphenylglycine (evidence: Structure-based inference [2])
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Name
                                                                          Unk04
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          BS330_28390
                                                                          Substrates
                                                                          4-hydroxyphenylglycine (evidence: Structure-based inference [2])
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Name
                                                                          Unk05
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          BS330_28390
                                                                          Substrates
                                                                          R-beta-hydroxytyrosine (evidence: Structure-based inference [2])
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Name
                                                                          Unk06
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          BS330_28395
                                                                          Substrates
                                                                          3,5-dihydroxyphenylglycine (evidence: Structure-based inference [2])
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Name
                                                                          Unk07
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          BS330_28465
                                                                          Substrates
                                                                          tyrosine (evidence: Structure-based inference [2])
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Annotation changelog

                                                                          Entry version: next

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2024-03-20
                                                                          MIBiG v4 annotathon
                                                                          • (ID: 5SRAIADCX5E626OGO7LYHFZD)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 4

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2022-10-07
                                                                          Update chemical activity to schema version 2.11
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 3

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2022-09-15
                                                                          Remove negative molecular mass
                                                                          • (ID: 3UOU7PODQJXIM6BEPUHHRRA5)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          2022-09-15
                                                                          Added NRP substrate specificities
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 2

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2019-10-16
                                                                          Migrated from v1.4
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 1

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2018-08-06
                                                                          Submitted
                                                                          • (ID: UZDMKOBVVEVI67YDKBV3PKAC)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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