BGC0001461 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001461 (Amycolatopsis keratiniphila subsp. nogabecina)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,NRPS-like,T3PKS	1	67,793	keratinimicin A / keratinimicin B / keratinimicin C / keratinimicin D	Other	88%

BGC0001461 - Region 1 - NRPS,NRPS-like,T3PKS

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Location: 1 - 67,793 nt. (total: 67,793 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 67,794
Label		BGC0001461

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001461.1	1.52	NRP	nogabecin	Amycolatopsis keratiniphila subsp. nogabecina
BGC0001955.1	1.27	Other	keratinimicin A, keratinimicin B, keratinimicin C, keratinimicin D	Amycolatopsis keratiniphila
BGC0000427.1	1.02	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000375.1	1.01	NRP	indigoidine	Streptomyces chromofuscus
BGC0000900.1	0.89	Other	ferrichrome	Aspergillus oryzae
BGC0000348.1	0.89	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001249.1	0.88	NRP	dimethylcoprogen	Alternaria alternata
BGC0001460.1	0.88	NRP	decaplanin	Amycolatopsis decaplanina DSM 44594
BGC0001718.1	0.87	NRP	okaramine D	Aspergillus aculeatus ATCC 16872
BGC0001717.1	0.86	Alkaloid	okaramine B	Penicillium simplicissimum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001461.1	0.91	NRP	nogabecin	Amycolatopsis keratiniphila subsp. nogabecina
BGC0001955.1	0.85	Other	keratinimicin A, keratinimicin B, keratinimicin C, keratinimicin D	Amycolatopsis keratiniphila
BGC0001460.1	0.75	NRP	decaplanin	Amycolatopsis decaplanina DSM 44594
BGC0001459.1	0.74	NRP	decaplanin	Amycolatopsis regifaucium
BGC0000455.1	0.72	NRP	vancomycin	Amycolatopsis orientalis HCCB10007
BGC0001462.1	0.71	NRP	avoparcin	Amycolatopsis coloradensis
BGC0000311.1	0.69	NRP	balhimycin	Amycolatopsis balhimycina DSM 5908
BGC0000419.1	0.68	NRP, Saccharide	ristomycin A	Amycolatopsis japonica
BGC0000427.1	0.68	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000375.1	0.67	NRP	indigoidine	Streptomyces chromofuscus

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 67793:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (hpg - D-bht) + (D-hpg - D-hpg - bht) + (dhpg) + (tyr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 55614:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (hpg - D-bht) + (D-hpg - D-hpg - bht) + (dhpg) + (tyr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 31692 - 67793:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (tyr) + (dhpg)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 42790 - 67793:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (tyr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

BS330_28385

Search NORINE for peptide: strict or relaxed

AMP-binding (14..405): hpg

NRPSPredictor2: hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: hpg

Stachelhaus prediction details:

Stachelhaus sequence:: DAyHLGLLCK
Nearest Stachelhaus code:: hpg
Stachelhaus code match:: 90% (moderate)

AMP-binding (1040..1426): bht

NRPSPredictor2: bht

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: bht

Stachelhaus prediction details:

Stachelhaus sequence:: DTSKtAAICK
Nearest Stachelhaus code:: bht
Stachelhaus code match:: 90% (moderate)

BS330_28390

Search NORINE for peptide: strict or relaxed

AMP-binding (457..852): hpg

NRPSPredictor2: hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: hpg

Stachelhaus prediction details:

Stachelhaus sequence:: DIFHLGLLCK
Nearest Stachelhaus code:: hpg
Stachelhaus code match:: 100% (strong)

AMP-binding (1947..2339): hpg

NRPSPredictor2: hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: hpg

Stachelhaus prediction details:

Stachelhaus sequence:: DAaHLGLLCK
Nearest Stachelhaus code:: hpg
Stachelhaus code match:: 90% (moderate)

AMP-binding (3462..3849): bht

NRPSPredictor2: bht

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: bht

Stachelhaus prediction details:

Stachelhaus sequence:: DASTLGAICK
Nearest Stachelhaus code:: bht
Stachelhaus code match:: 100% (strong)

BS330_28395

Search NORINE for peptide: strict or relaxed

AMP-binding (471..865): dhpg

NRPSPredictor2: dhpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: dhpg, hpg
Single AA prediction:: dhpg

Stachelhaus prediction details:

Stachelhaus sequence:: DPYHeGTLCK
Nearest Stachelhaus code:: dhpg
Stachelhaus code match:: 90% (moderate)

BS330_28465

Search NORINE for peptide: strict or relaxed

AMP-binding (12..402): tyr

NRPSPredictor2: tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: tyr

Stachelhaus prediction details:

Stachelhaus sequence:: DAATLAAVAK
Nearest Stachelhaus code:: tyr
Stachelhaus code match:: 100% (strong)