Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001463.1:
Cluster 1Other16707

BGC0001463, tetrabromopyrrole biosynthetic gene cluster from Pseudoalteromonas piscicida. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: 2,3,4,5-tetrabromopyrrole
ChemSpider ID: 3797328
SMILES string: Copy to clipboard
Molecular formula:
Average molecular mass: Da
Molecular activity: Inhibitor, Signalling
Molecular target: microsomal sarcoplasmic/endoplasmic reticulum (SR/ER) Ca2+ ATPase

Class-specific details

Biosynthetic class(es):
Other

Gene cluster description

tetrabromopyrrole (BGC0001463). Gene Cluster 1. Biosynthetic class = Other. GenBank KT808878, positions 1-6707. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Enzymatic assays, Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Bradley S. Moore (Scripps Institution of Oceanography)

Literature references

1. El Gamal A et al. (2016) Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase-thioesterase enzyme pair. Proc Natl Acad Sci U S A 113(14):3797-802. doi:
2. Agarwal V et al. (2014) Biosynthesis of polybrominated aromatic organic compounds by marine bacteria. Nat Chem Biol 10(8):640-7. doi: 10.1038/nchembio.1564. Epub 2014 Jun
3. El Gamal A et al. (2016) Enzymatic Reductive Dehalogenation Controls the Biosynthesis of Marine Bacterial Pyrroles. J Am Chem Soc 138(40):13167-13170. doi: 10.1021/jacs.6b08512. Epub
4. Zheng J et al. (2018) Organohalogens Naturally Biosynthesized in Marine Environments and Produced as Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca(2+) Dynamics. Environ Sci Technol 52(9):5469-5478. doi: 10.1021/acs.est.8b00512.