BGC0001469: marthiapeptide A biosynthetic gene cluster from Brevibacillus sp. Leaf182
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Location: 237,040 - 298,088 nt. (total: 61,049 nt).
This entry is originally from NCBI GenBank LMPN02000037.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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General
Compounds
Genes
Biosynthesis
Operons
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001469
Short description marthiapeptide A biosynthetic gene cluster from Brevibacillus sp. Leaf182
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "Reference of the current paper describing the biosynthetic gene cluster will be added as soon as published. "
Biosynthetic class(es)
  • NRPS (Type I)
Loci
LMPN02000037.1
252909 - 282961
via Knock-out studies
Compounds
  • marthiapeptide A
Species Brevibacillus sp. Leaf182 [taxonomy]
References
Chemical products information
marthiapeptide A Evidence: NMR, Mass spectrometry
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C30H31N7O3S4
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ASG16_028310
  • RAT94085.1
  • marD
 252909 - 253166 (-) transcriptional regulator
  • Regulation
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  • ASG16_028315
  • RAT94086.1
 253520 - 253990 (-) hypothetical protein
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    • ASG16_028320
    • RAT94087.1
    • marF
    		 254099 - 254710 (-) DUF 4304 domain-containing protein
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      • ASG16_028325
      • RAT94088.1
      • marG
      		 254767 - 255186 (-) DUF 2809 domain-containing protein
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        • ASG16_028330
        • RAT94089.1
        • marH
        		 255445 - 256374 (-) acetamidase
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          • ASG16_028335
          		 256672 - 256761 (-) iron chaperone
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            • ASG16_028340
            • RAT94090.1
            • marB
            		 257040 - 274781 (-) NRPS
            • Scaffold biosynthesis
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            • ASG16_028345
            • RAT94091.1
            • marA
            		 274798 - 278088 (-) NRPS
            • Scaffold biosynthesis
            • Knock-out
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            • ASG16_028350
            • RAT94092.1
            • marC
            		 278596 - 279609 (-) dehydrogenase
            • Tailoring
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            • ASG16_028355
            • RAT94093.1
            • cysE__marJ
            		 279647 - 280219 (-) serine O-acetyl-transferase
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              • ASG16_028360
              • RAT94094.1
              • marK
              		 280585 - 281148 (+) PadR family transcriptional regulator
              • Regulation
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              • ASG16_028365
              • RAT94095.1
              • marL
              		 281524 - 282960 (-) sensor histidine kinase
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                • ASG16_028370
                • RAT94096.1
                • marM
                		 282961 - 283614 (-) DNA-binding response regulator
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                  Biosynthesis information

                  Biosynthetic modules

                  Name
                  1
                  Type
                  nrps-type1
                  Genes
                  marA
                  Substrates
                  isoleucine (evidence: Sequence-based prediction)
                  Integrated Monomers
                  Domains
                  condensation (DCL), adenylation, epimerase
                  Name
                  2
                  Type
                  nrps-type1
                  Genes
                  marB
                  Substrates
                  serine (evidence: Sequence-based prediction)
                  Integrated Monomers
                  Domains
                  condensation (DCL), adenylation, epimerase
                  Name
                  3
                  Type
                  nrps-type1
                  Genes
                  marB
                  Substrates
                  cysteine (evidence: Sequence-based prediction)
                  Integrated Monomers
                  Domains
                  condensation (Heterocyclization), adenylation
                  Name
                  4
                  Type
                  nrps-type1
                  Genes
                  marB
                  Substrates
                  cysteine (evidence: Sequence-based prediction)
                  Integrated Monomers
                  Domains
                  condensation (Heterocyclization), adenylation
                  Name
                  5
                  Type
                  nrps-type1
                  Genes
                  marB
                  Substrates
                  cysteine (evidence: Sequence-based prediction)
                  Integrated Monomers
                  Domains
                  condensation (Heterocyclization), adenylation
                  Name
                  6
                  Type
                  nrps-type1
                  Genes
                  marB
                  Substrates
                  cysteine (evidence: Sequence-based prediction)
                  Integrated Monomers
                  Domains
                  condensation (Heterocyclization), adenylation
                  Operons
                  Genes Evidence
                  marD, marH, ASG16_028315, marA, cysE__marJ, marG, marF, marB
                  marK
                  Annotation changelog

                  Entry version: 4

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-10-07
                  Update chemical activity to schema version 2.11
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 3

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-09-15
                  Corrected NRP module activity
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Changed amino acid substrates to lower case
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 2

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2019-10-16
                  Migrated from v1.4
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2019-10-16
                  Updated compound(s) information (NPAtlas curation)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 1

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2018-08-06
                  Submitted
                  • (ID: CUIZDUBUBVAF27VHF4OZXTI3)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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