Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001469.1:
Cluster 1NRP130053

BGC0001469, marthiapeptide A biosynthetic gene cluster from Brevibacillus sp. Leaf182. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: marthiapeptide A
PubChem ID: 71459810
SMILES string: Copy to clipboard
Molecular formula: C30H31N7O3S4
Average molecular mass: 665.864 Da
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
NRP
Other (cyclic)
Thioesterase type:
Unknown
Release / cyclization type:
Macrolactamization

Nonribosomal peptide synthetases:
marA (RAT94091.1)
Module 1
A specificity: Isoleucine
Evidence for specificity: Sequence-based prediction
AA is epimerized
C domain subtype: DCL
Scaffold-modifying domain: Epimerization
marB (RAT94090.1)
Module 2
A specificity: Serine
Evidence for specificity: Sequence-based prediction
AA is epimerized
C domain subtype: DCL
Scaffold-modifying domain: Epimerization
Module 3
A specificity: Cysteine
Evidence for specificity: Sequence-based prediction
C domain subtype: Heterocyclization
Scaffold-modifying domain: Heterocyclization
Module 4
A specificity: Cysteine
Evidence for specificity: Sequence-based prediction
C domain subtype: Heterocyclization
Scaffold-modifying domain: Heterocyclization
Module 5
A specificity: Cysteine
Evidence for specificity: Sequence-based prediction
C domain subtype: Heterocyclization
Scaffold-modifying domain: Heterocyclization
Module 6
A specificity: Cysteine
Evidence for specificity: Sequence-based prediction
C domain subtype: Heterocyclization
Scaffold-modifying domain: Heterocyclization

Gene cluster description

marthiapeptide A (BGC0001469). Gene Cluster 1. Biosynthetic class = NRP. GenBank LMPN02000037, positions 252909-282961. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Comments:Reference of the current paper describing the biosynthetic gene cluster will be added as soon as published.
Contact for this cluster:Eric J. N. Helfrich (ETH Zurich)

Literature references