BGC0001504 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001504 (Amycolatopsis sp. AA4)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	13,734	tetronasin	Polyketide	5%

BGC0001504 - Region 1 - T1PKS

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Location: 1 - 13,734 nt. (total: 13,734 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 13,735
Label		BGC0001504

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001504.1	0.67	Polyketide	amycomicin	Amycolatopsis sp. AA4
BGC0001909.1	0.32	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001068.1	0.28	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001280.1	0.26	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.26	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001223.1	0.24	Other	hydroxysporine	uncultured bacterium
BGC0001141.1	0.24	Polyketide	4-epi-15-epi-brefeldin A	Penicillium brefeldianum
BGC0001201.1	0.23	Terpene	eremophilene	Sorangium cellulosum So ce56
BGC0000056.1	0.23	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0000003.1	0.23	Polyketide	AF-toxin	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001504.1	0.87	Polyketide	amycomicin	Amycolatopsis sp. AA4
BGC0001909.1	0.66	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001068.1	0.62	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001280.1	0.60	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.60	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001223.1	0.57	Other	hydroxysporine	uncultured bacterium
BGC0001141.1	0.57	Polyketide	4-epi-15-epi-brefeldin A	Penicillium brefeldianum
BGC0001201.1	0.57	Terpene	eremophilene	Sorangium cellulosum So ce56
BGC0000056.1	0.57	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0000003.1	0.56	Polyketide	AF-toxin	Alternaria alternata

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 13734:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (redmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

CU254_21755

Search NORINE for peptide: strict or relaxed

AMP-binding (15..419): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: hiWcVGintK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 40% (weak)

CU254_21765

PKS_AT (544..834): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 166.8
inactive: 105.8
Methylmalonyl-CoA: 62.3
Methoxymalonyl-CoA: 59.3
Propionyl-CoA: 48.2
Ethylmalonyl-CoA: 38.7
CHC-CoA: 33.9
2-Methylbutyryl-CoA: 31.1
Isobutyryl-CoA: 31.0
fatty_acid: 30.9
Benzoyl-CoA: 21.1
Acetyl-CoA: 13.8
trans-1,2-CPDA: 11.0
3-Methylbutyryl-CoA: 0.0