BGC0001511: ansamitocin P-3 biosynthetic gene cluster from Actinosynnema pretiosum subsp. pretiosum
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Location: 1 - 82,944 nt. (total: 82,944 nt).
This entry is originally from NCBI GenBank KY489977.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
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Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001511
Short description ansamitocin P-3 biosynthetic gene cluster from Actinosynnema pretiosum subsp. pretiosum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
KY489977.1
via
Compounds
  • ansamitocin P-3
Species Actinosynnema pretiosum subsp. pretiosum [taxonomy]
References
Chemical products information
ansamitocin P-3 Evidence:
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C32H43Cl1N2O9
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AQZ37086.1
 2239 - 3120 (-) oxidoreductase
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    • AQZ37087.1
    		 3191 - 3787 (+) TetR-family transcriptional regulator
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      • AQZ37088.1
      		 4039 - 4305 (+) hypothetical protein
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        • AQZ37089.1
        		 4349 - 6601 (+) ABC transporter transmembrane region protein
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          • AQZ37090.1
          		 6610 - 7860 (+) Na+/H+ antiporter
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            • AQZ37091.1
            		 7959 - 8609 (-) hypothetical protein
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              • AQZ37092.1
              		 8779 - 9825 (-) O-methyltransferase family 2
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                • AQZ37093.1
                		 10015 - 13191 (+) LuxR-family transcriptional regulator
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                  • AQZ37094.1
                  		 13402 - 18195 (+) polyketide synthase
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                    • AQZ37095.1
                    		 18205 - 28224 (+) polyketide synthase
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                      • AQZ37096.1
                      		 28226 - 29005 (+) N-acetyltransferase
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                        • AQZ37097.1
                        		 29096 - 29992 (-) N-methyltransferase
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                          • AQZ37098.1
                          		 29989 - 31524 (-) epoxidase
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                            • AQZ37099.1
                            		 31536 - 32861 (-) halogenase
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                              • AQZ37100.1
                              		 33118 - 34113 (+) 3-hydroxybutyryl-CoA dehydrogenase
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                                • AQZ37101.1
                                		 34110 - 34382 (+) acyl carrier protein
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                                  • AQZ37102.1
                                  		 34387 - 35490 (+) butyryl-CoA dehydrogenase
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                                    • AQZ37103.1
                                    		 35601 - 36866 (+) FkbH
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                                      • AQZ37104.1
                                      		 36859 - 37521 (+) O-methyltransferase
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                                        • AQZ37105.1
                                        		 37699 - 40458 (+) transcriptional activator
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                                          • AQZ37106.1
                                          		 40550 - 41620 (+) acyltransferase MdmB
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                                            • AQZ37107.1
                                            		 41635 - 41982 (-) hypothetical protein
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                                              • AQZ37108.1
                                              		 42212 - 44224 (+) carbamoyltransferase
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                                                • AQZ37109.1
                                                		 44620 - 44985 (+) hypothetical protein
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                                                  • AQZ37110.1
                                                  		 45362 - 45547 (+) mobile element protein
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                                                    • AQZ37111.1
                                                    		 45953 - 46396 (-) 3-dehydroquinate dehydratase II
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                                                      • AQZ37112.1
                                                      		 46608 - 47774 (+) lipopolysaccharide biosynthesis protein RffA
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                                                        • AQZ37113.1
                                                        		 47963 - 61690 (+) polyketide synthase
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                                                          • AQZ37114.1
                                                          		 61687 - 71115 (+) polyketide synthase
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                                                            • AQZ37115.1
                                                            		 71192 - 72400 (+) glycosyltransferase
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                                                              • AQZ37116.1
                                                              		 72668 - 73693 (+) 3-oxoacyl-[acyl-carrier protein] reductase
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                                                                • AQZ37117.1
                                                                		 73773 - 74237 (-) hypothetical protein
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                                                                  • AQZ37118.1
                                                                  		 74419 - 75039 (-) transcriptional regulator TetR family
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                                                                    • AQZ37119.1
                                                                    		 75064 - 75657 (+) cytochrome P450
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                                                                      • AQZ37120.1
                                                                      		 76848 - 76976 (+) hypothetical protein
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                                                                        • AQZ37121.1
                                                                        		 77013 - 78002 (-) RNA polymerase sigma factor
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                                                                          • AQZ37122.1
                                                                          		 78227 - 78859 (-) putative methyltransferase
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                                                                            • AQZ37123.1
                                                                            		 78974 - 79447 (+) Na+/H+ antiporter NhaA type
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                                                                              • AQZ37124.1
                                                                              		 79447 - 79743 (+) Na+/H+ antiporter
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                                                                                • AQZ37125.1
                                                                                		 79728 - 80303 (-) dihydrofolate reductase
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                                                                                  • AQZ37126.1
                                                                                  		 80390 - 81004 (+) transcriptional regulator TetR family
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                                                                                    • AQZ37127.1
                                                                                    		 81256 - 82941 (-) hypothetical protein
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                                                                                      Biosynthesis information
                                                                                      Annotation changelog

                                                                                      Entry version: 4

                                                                                      Date
                                                                                      Changes
                                                                                      Submitters
                                                                                      Reviewers
                                                                                      2022-10-07
                                                                                      Update chemical activity to schema version 2.11
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                      Entry version: 3

                                                                                      Date
                                                                                      Changes
                                                                                      Submitters
                                                                                      Reviewers
                                                                                      2022-09-15
                                                                                      Updated bioactivity data
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                      Entry version: 2

                                                                                      Date
                                                                                      Changes
                                                                                      Submitters
                                                                                      Reviewers
                                                                                      2019-10-16
                                                                                      Migrated from v1.4
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                      Entry version: 1

                                                                                      Date
                                                                                      Changes
                                                                                      Submitters
                                                                                      Reviewers
                                                                                      2018-08-06
                                                                                      Submitted
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      Detailed domain annotation
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