BGC0001558: cosmomycin C biosynthetic gene cluster from Streptomyces sp. CNT302
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Location: 104,106 - 158,376 nt. (total: 54,271 nt).
This entry is originally from NCBI GenBank NZ_KB898282.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001558
Short description cosmomycin C biosynthetic gene cluster from Streptomyces sp. CNT302
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
NZ_KB898282.1
104106 - 158376
via
Compounds
  • cosmomycin C
Species Streptomyces sp. CNT302 [taxonomy]
References
Chemical products information
cosmomycin C Evidence:
Copy SMILES
C60H88N2O21
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • D329_RS0122250
  • WP_026281939.1
  • rfbA
 104106 - 104981 (-) glucose-1-phosphate thymidylyltransferase RfbA
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    • D329_RS0122255
    • WP_017947353.1
    		 105268 - 105522 (+) acyl carrier protein
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      • D329_RS32350
      • WP_018891721.1
      		 105794 - 106564 (+) AfsR/SARP family transcriptional regulator
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        • D329_RS0122265
        • WP_018891722.1
        		 106645 - 107502 (-) methyltransferase domain-containing protein
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          • D329_RS0122270
          • WP_026281940.1
          		 107690 - 108127 (+) ester cyclase
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            • D329_RS32355
            • WP_018891724.1
            		 108168 - 109277 (+) methyltransferase
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              • D329_RS0122280
              • WP_018891725.1
              		 109282 - 110178 (+) alpha/beta fold hydrolase
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                • D329_RS0122285
                • WP_018891726.1
                		 110175 - 110972 (+) class I SAM-dependent methyltransferase
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                  • D329_RS0122290
                  • WP_018891727.1
                  		 110969 - 112564 (+) FAD-dependent oxidoreductase
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                    • D329_RS0122295
                    • WP_018891728.1
                    		 112656 - 113663 (-) Gfo/Idh/MocA family oxidoreductase
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                      • D329_RS0122300
                      • WP_018891729.1
                      		 113859 - 114989 (+) hypothetical protein
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                        • D329_RS0122305
                        • WP_018891730.1
                        		 114986 - 116305 (+) activator-dependent family glycosyltransferase
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                          • D329_RS0122310
                          • WP_018891731.1
                          • rfbH
                          		 116316 - 117617 (+) lipopolysaccharide biosynthesis protein RfbH
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                            • D329_RS0122315
                            • WP_018891732.1
                            • fabG
                            		 117625 - 118410 (+) 3-oxoacyl-ACP reductase FabG
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                              • D329_RS0122320
                              • WP_018891733.1
                              		 118419 - 119777 (+) SRPBCC family protein
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                                • D329_RS0122325
                                • WP_018891734.1
                                		 119958 - 120689 (-) SDR family oxidoreductase
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                                  • D329_RS0122330
                                  • WP_018891735.1
                                  		 120745 - 121152 (-) nuclear transport factor 2 family protein
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                                    • D329_RS0122335
                                    • WP_018891736.1
                                    		 121300 - 122079 (+) cyclase family protein
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                                      • D329_RS0122340
                                      • WP_018891737.1
                                      		 122135 - 122863 (+) class I SAM-dependent methyltransferase
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                                        • D329_RS0122345
                                        • WP_018891738.1
                                        		 122860 - 123969 (+) DegT/DnrJ/EryC1/StrS family aminotransferase
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                                          • D329_RS0122350
                                          • WP_018891739.1
                                          		 124045 - 125511 (-) NDP-hexose 2,3-dehydratase family protein
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                                            • D329_RS0122355
                                            • WP_018891740.1
                                            		 125508 - 126545 (-) NAD(P)-dependent oxidoreductase
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                                              • D329_RS0122360
                                              • WP_018891741.1
                                              		 126512 - 127138 (-) dTDP-4-dehydrorhamnose 3,5-epimerase family protein
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                                                • D329_RS0122365
                                                • WP_018891742.1
                                                		 127207 - 128499 (-) activator-dependent family glycosyltransferase
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                                                  • D329_RS0122375
                                                  • WP_018891744.1
                                                  		 128786 - 129349 (+) PadR family transcriptional regulator
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                                                    • D329_RS0122380
                                                    • WP_018891745.1
                                                    		 129730 - 130710 (+) hypothetical protein
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                                                      • D329_RS0122390
                                                      • WP_018891746.1
                                                      		 130826 - 131161 (+) antibiotic biosynthesis monooxygenase family protein
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                                                        • D329_RS0122395
                                                        • WP_017947381.1
                                                        		 131158 - 132426 (+) beta-ketoacyl-[acyl-carrier-protein] synthase family protein
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                                                          • D329_RS0122400
                                                          • WP_018891747.1
                                                          		 132423 - 133667 (+) ketosynthase chain-length factor
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                                                            • D329_RS0122405
                                                            • WP_018891748.1
                                                            		 133664 - 134698 (+) ketoacyl-ACP synthase III family protein
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                                                              • D329_RS0122410
                                                              • WP_018891749.1
                                                              		 134695 - 135747 (+) acyltransferase domain-containing protein
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                                                                • D329_RS0122415
                                                                • WP_018891750.1
                                                                		 135878 - 137128 (+) P450-derived glycosyltransferase activator
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                                                                  • D329_RS0122420
                                                                  • WP_018891751.1
                                                                  		 137163 - 138443 (+) activator-dependent family glycosyltransferase
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                                                                    • D329_RS0122425
                                                                    • WP_018891752.1
                                                                    • rfbB
                                                                    		 138465 - 139454 (+) dTDP-glucose 4,6-dehydratase
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                                                                      • D329_RS0122430
                                                                      • WP_017947388.1
                                                                      		 139523 - 140509 (+) daunorubicin resistance protein DrrA family ABC transporter ATP-binding protein
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                                                                        • D329_RS0122435
                                                                        • WP_018891753.1
                                                                        		 140509 - 141339 (+) ABC transporter permease
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                                                                          • D329_RS0122440
                                                                          • WP_018891754.1
                                                                          		 141547 - 142071 (+) glutathione peroxidase
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                                                                            • D329_RS0122445
                                                                            • WP_018891755.1
                                                                            		 142125 - 144410 (+) excinuclease ABC subunit UvrA
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                                                                              • D329_RS0122450
                                                                              • WP_018891756.1
                                                                              		 144578 - 145126 (+) DinB family protein
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                                                                                • D329_RS32360
                                                                                • WP_051093176.1
                                                                                		 145151 - 145753 (+) PadR family transcriptional regulator
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                                                                                  • D329_RS0122460
                                                                                  • WP_018891758.1
                                                                                  		 146013 - 146288 (+) DUF6343 family protein
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                                                                                    • D329_RS32365
                                                                                    • WP_018891759.1
                                                                                    		 146483 - 147889 (+) YihY/virulence factor BrkB family protein
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                                                                                      • D329_RS0122470
                                                                                      • WP_017947396.1
                                                                                      		 148248 - 148670 (+) DUF350 domain-containing protein
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                                                                                        • D329_RS0122475
                                                                                        • WP_018891760.1
                                                                                        		 148887 - 149087 (+) hypothetical protein
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                                                                                          • D329_RS0122480
                                                                                          • WP_018891761.1
                                                                                          		 149370 - 150248 (+) SigB/SigF/SigG family RNA polymerase sigma factor
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                                                                                            • D329_RS0122485
                                                                                            • WP_018891762.1
                                                                                            		 150337 - 150687 (+) hypothetical protein
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                                                                                              • D329_RS0122490
                                                                                              • WP_017947400.1
                                                                                              		 150697 - 151122 (-) CBS domain-containing protein
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                                                                                                • D329_RS0122495
                                                                                                • WP_018891763.1
                                                                                                		 151514 - 151756 (+) DUF6381 family protein
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                                                                                                  • D329_RS0122500
                                                                                                  • WP_018891764.1
                                                                                                  		 151890 - 154214 (+) SpoIIE family protein phosphatase
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                                                                                                    • D329_RS0122505
                                                                                                    • WP_018891765.1
                                                                                                    		 154256 - 157300 (-) HAMP domain-containing protein
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                                                                                                      • D329_RS0122510
                                                                                                      • WP_017947404.1
                                                                                                      		 157481 - 157918 (-) ATP-binding protein
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                                                                                                        • D329_RS0122515
                                                                                                        • WP_018891766.1
                                                                                                        		 157984 - 158376 (-) STAS domain-containing protein
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                                                                                                          Biosynthesis information
                                                                                                          Annotation changelog

                                                                                                          Entry version: 4

                                                                                                          Date
                                                                                                          Changes
                                                                                                          Submitters
                                                                                                          Reviewers
                                                                                                          2022-10-07
                                                                                                          Update chemical activity to schema version 2.11
                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                          Entry version: 3

                                                                                                          Date
                                                                                                          Changes
                                                                                                          Submitters
                                                                                                          Reviewers
                                                                                                          2022-09-15
                                                                                                          Updated bioactivity data
                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                          Entry version: 2

                                                                                                          Date
                                                                                                          Changes
                                                                                                          Submitters
                                                                                                          Reviewers
                                                                                                          2019-10-16
                                                                                                          Migrated from v1.4
                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                          2019-10-16
                                                                                                          Updated compound(s) information (NPAtlas curation)
                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                          Entry version: 1

                                                                                                          Date
                                                                                                          Changes
                                                                                                          Submitters
                                                                                                          Reviewers
                                                                                                          2018-08-06
                                                                                                          Submitted
                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                          Detailed domain annotation
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