BGC0001575 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001575 (Ruminococcus sp. 5_1_39BFAA)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	29,972	PZN5/PZN6/PZN7/PZN9/PZN10/PZN11	NRPS:Type I	100%

BGC0001575 - Region 1 - NRPS

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Location: 1 - 29,972 nt. (total: 29,972 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 29,973
Label		BGC0001575

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001575	0.89	NRP	dipeptide aldehydes	Ruminococcus sp. 5_1_39BFAA
BGC0000308	0.26	NRP	aureusimine A, aureusimine B, aureusimine C	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001928	0.25	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002076	0.23	Other	4,5-didehydroacaterin, acaterin	Pseudomonas jessenii
BGC0001627	0.22	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv
BGC0001444	0.21	Other (shikimate derived)	caboxamycin	Streptomyces sp. NTK 937
BGC0002437	0.21	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0001197	0.21	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0001825	0.21	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0002286	0.20	NRP	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001575	0.96	NRP	dipeptide aldehydes	Ruminococcus sp. 5_1_39BFAA
BGC0000308	0.59	NRP	aureusimine A, aureusimine B, aureusimine C	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001928	0.59	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002076	0.56	Other	4,5-didehydroacaterin, acaterin	Pseudomonas jessenii
BGC0001627	0.54	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv
BGC0001444	0.54	Other (shikimate derived)	caboxamycin	Streptomyces sp. NTK 937
BGC0002437	0.54	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0001197	0.54	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0001825	0.53	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0002286	0.53	NRP	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 6 - 29972:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - X - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

RSAG_RS12305

AMP-binding (20..419): X

nrpys: Leu, Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVLTDGGISK
Nearest Stachelhaus code(s):: Leu or Trp DVLTDGGISK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1033..1421): X

nrpys: Leu, Trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAMFSGAIFK
Nearest Stachelhaus code(s):: Leu or Trp DAMFSGAIFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2027..2418): X

nrpys: Leu, Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAITTGGVSK
Nearest Stachelhaus code(s):: Leu or Trp DAITTGGVSK (100% 8Å match)
Stachelhaus code match:: 100% (strong)