BGC0001575: PZN5 biosynthetic gene cluster from Ruminococcus sp. 5_1_39BFAA
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Location: 1,882,321 - 1,912,292 nt. (total: 29,972 nt).
This entry is originally from NCBI GenBank NZ_ACII02000003.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001575
Short description PZN5 biosynthetic gene cluster from Ruminococcus sp. 5_1_39BFAA
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
NZ_ACII02000003.1
1882321 - 1912292
via
Compounds
  • PZN5
  • PZN6
  • PZN7
  • PZN9
  • PZN10
  • PZN11
Species Ruminococcus sp. 5_1_39BFAA [taxonomy]
References
Chemical products information
PZN5 [synonyms: Lumizinone A] Evidence: NMR [1]
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C15H18N2O2
Chemical database entries
NPAtlas
PubCHEM
ChEBI
PZN6 [synonyms: 3-[(2R)-butan-2-yl]-6-[(4-hydroxyphenyl)methyl]-1H-pyrazin-2-one] Evidence: NMR [1]
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C15H18N2O2
Chemical database entries
PubCHEM
PZN7 [synonyms: 6-(1H-indol-3-ylmethyl)-3-propan-2-yl-1H-pyrazin-2-one] Evidence: NMR [1]
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C16H17N3O1
Chemical database entries
PubCHEM
PZN9 [synonyms: 6-(1H-indol-3-ylmethyl)-3-(2-methylpropyl)-1H-pyrazin-2-one] Evidence: NMR [1]
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C17H19N3O1
Chemical database entries
PubCHEM
PZN10 [synonyms: 6-Benzyl-3-isobutylpyrazin-2(1H)-one] Evidence: NMR [1]
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C15H18N2O1
Chemical database entries
PubCHEM
PZN11 [synonyms: 6-benzyl-3-[(2R)-butan-2-yl]-1H-pyrazin-2-one] Evidence: NMR [1]
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C15H18N2O1
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • RSAG_RS12235
  • WP_008704367.1
 1883495 - 1883704 (-) DUF6219 family protein
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    • RSAG_RS19580
    • WP_008704366.1
    		 1883770 - 1883901 (-) hypothetical protein
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      • RSAG_RS12240
      • WP_008704365.1
      		 1884731 - 1885123 (+) aspartate 1-decarboxylase
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        • RSAG_RS12245
        • WP_008704364.1
        • panC
        		 1885233 - 1886072 (+) pantoate--beta-alanine ligase
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          • RSAG_RS12250
          • WP_008704363.1
          		 1886076 - 1887059 (+) bile acid:sodium symporter family protein
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            • RSAG_RS12255
            • WP_020993838.1
            		 1887184 - 1888578 (-) helix-turn-helix domain-containing protein
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              • RSAG_RS12260
              • WP_020993839.1
              		 1888935 - 1891745 (+) acetoacetate decarboxylase family protein
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                • RSAG_RS12265
                • WP_008704360.1
                		 1891759 - 1892514 (+) SDR family NAD(P)-dependent oxidoreductase
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                  • RSAG_RS12270
                  • WP_008704359.1
                  		 1892715 - 1894406 (+) transposase
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                    • RSAG_RS19585
                    • WP_008704358.1
                    		 1894422 - 1894553 (+) hypothetical protein
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                      • RSAG_RS12275
                      • WP_242832785.1
                      		 1894666 - 1895367 (+) toll/interleukin-1 receptor domain-containing protein
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                        • RSAG_RS12280
                        • WP_044952088.1
                        		 1896246 - 1896689 (+) VanZ family protein
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                          • RSAG_RS12285
                          • WP_008704353.1
                          		 1897079 - 1897915 (+) deoxyribonuclease IV
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                            • RSAG_RS12290
                            • WP_020993842.1
                            		 1898032 - 1898412 (+) hypothetical protein
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                              • RSAG_RS12295
                              • WP_020993843.1
                              		 1898564 - 1900435 (+) PQQ-binding-like beta-propeller repeat protein
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                                • RSAG_RS12300
                                • WP_008704346.1
                                		 1900568 - 1902313 (+) MATE family efflux transporter
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                                  • RSAG_RS12305
                                  • WP_020993844.1
                                  		 1902327 - 1911311 (+) non-ribosomal peptide synthetase
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                                    • RSAG_RS12310
                                    • WP_008704342.1
                                    		 1911331 - 1911633 (+) STAS domain-containing protein
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                                      • RSAG_RS12315
                                      • WP_008704340.1
                                      		 1911645 - 1912292 (+) 4'-phosphopantetheinyl transferase superfamily protein
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                                        Biosynthesis information

                                        Biosynthetic modules

                                        Name
                                        Unk01
                                        Type
                                        nrps-type1
                                        Genes
                                        RSAG_RS12305
                                        Substrates
                                        valine, leucine, isoleucine, phenylalanine, tryptophan, tyrosine (evidence: Mass spectrometry, Knock-out studies)
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk02
                                        Type
                                        nrps-type1
                                        Genes
                                        RSAG_RS12305
                                        Substrates
                                        valine, leucine, isoleucine, phenylalanine, tryptophan, tyrosine (evidence: Mass spectrometry, Knock-out studies)
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk03
                                        Type
                                        nrps-type1
                                        Genes
                                        RSAG_RS12305
                                        Substrates
                                        valine, leucine, isoleucine, phenylalanine, tryptophan, tyrosine (evidence: Mass spectrometry, Knock-out studies)
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Annotation changelog

                                        Entry version: next

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2024-05-13
                                        MIBiG v4 annotathon
                                        • (ID: 3OFRGD3XQY2W5RRQYRWHG5KI)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                        Entry version: 3

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2022-09-15
                                        Added NRP substrate specificities
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                        Entry version: 2

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2019-10-16
                                        Migrated from v1.4
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                        Entry version: 1

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2018-08-06
                                        Submitted
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        Detailed domain annotation
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