BGC0001596: fluostatin M biosynthetic gene cluster from Streptomyces albus
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 5,974,062 - 6,020,749 nt. (total: 46,688 nt).
This entry is originally from NCBI GenBank NZ_CP010519.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001596
Short description fluostatin M biosynthetic gene cluster from Streptomyces albus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type II aromatic)
Loci
NZ_CP010519.1
5974062 - 6020749
via
Compounds
  • fluostatin M
  • fluostatin N
  • fluostatin O
  • fluostatin P
  • fluostatin Q
Species Streptomyces albus [taxonomy]
References
Chemical products information
fluostatin M Evidence: NMR [1]
Copy SMILES
C19H16O6
Chemical database entries
NPAtlas
fluostatin N Evidence: NMR [1]
Copy SMILES
C19H18O6
Chemical database entries
NPAtlas
fluostatin O Evidence: NMR [1]
Copy SMILES
C19H18O5
Chemical database entries
NPAtlas
fluostatin P Evidence: NMR [1]
Copy SMILES
C19H18O7
Chemical database entries
NPAtlas
fluostatin Q Evidence: NMR [1], X-ray crystallography [1]
Copy SMILES
C19H16O6
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SLNWT_RS23545
  • WP_052482552.1
 5974062 - 5974529 (+) ATP-binding protein
    copy AA seq
    copy Nt seq
    • SLNWT_RS23550
    • WP_052482553.1
    		 5974570 - 5975178 (-) TetR/AcrR family transcriptional regulator
      copy AA seq
      copy Nt seq
      • SLNWT_RS23555
      • WP_040258142.1
      		 5975483 - 5975893 (+) F420-dependent PPOX class oxidoreductase
        copy AA seq
        copy Nt seq
        • SLNWT_RS23560
        • WP_040253434.1
        		 5976074 - 5976523 (-) nuclear transport factor 2 family protein
          copy AA seq
          copy Nt seq
          • SLNWT_RS23565
          • WP_040253436.1
          		 5976688 - 5978157 (+) monooxygenase
            copy AA seq
            copy Nt seq
            • SLNWT_RS23570
            • WP_040253438.1
            		 5978227 - 5978916 (+) anthrone monooxygenase
              copy AA seq
              copy Nt seq
              • SLNWT_RS23575
              		 5979066 - 5980552 (+) bilirubin oxidase
                copy AA seq
                copy Nt seq
                • SLNWT_RS23580
                • WP_040253440.1
                		 5981134 - 5981457 (+) TcmI family type II polyketide cyclase
                  copy AA seq
                  copy Nt seq
                  • SLNWT_RS23585
                  • WP_040253443.1
                  		 5981459 - 5982730 (+) ketosynthase
                    copy AA seq
                    copy Nt seq
                    • SLNWT_RS23590
                    • WP_040253445.1
                    		 5982727 - 5983941 (+) ketosynthase chain-length factor
                      copy AA seq
                      copy Nt seq
                      • SLNWT_RS23595
                      • WP_040253447.1
                      		 5984036 - 5984305 (+) acyl carrier protein
                        copy AA seq
                        copy Nt seq
                        • SLNWT_RS23600
                        • WP_040253449.1
                        		 5984324 - 5985118 (+) KR-domain containing protein
                          copy AA seq
                          copy Nt seq
                          • SLNWT_RS23605
                          • WP_040253451.1
                          		 5985168 - 5986109 (+) cyclase
                            copy AA seq
                            copy Nt seq
                            • SLNWT_RS23610
                            • WP_040253452.1
                            		 5986109 - 5987566 (+) oxydoreductase
                              copy AA seq
                              copy Nt seq
                              • SLNWT_RS23615
                              • WP_040253455.1
                              		 5987649 - 5989169 (+) monooxygenase
                                copy AA seq
                                copy Nt seq
                                • SLNWT_RS23620
                                • WP_052482554.1
                                		 5989315 - 5990256 (+) thioesterase
                                  copy AA seq
                                  copy Nt seq
                                  • SLNWT_RS23625
                                  • WP_052482555.1
                                  		 5990382 - 5991056 (+) JadM phosphopantetheinyl transferase-like protein
                                    copy AA seq
                                    copy Nt seq
                                    • SLNWT_RS23630
                                    • WP_052482556.1
                                    		 5991096 - 5992670 (+) acyl-CoA carboxylase subunit beta
                                      copy AA seq
                                      copy Nt seq
                                      • SLNWT_RS23635
                                      • WP_040258146.1
                                      		 5992890 - 5993105 (+) acyl-CoA carboxylase subunit epsilon
                                        copy AA seq
                                        copy Nt seq
                                        • SLNWT_RS23640
                                        • WP_040253457.1
                                        		 5993261 - 5994046 (-) hypothetical protein
                                          copy AA seq
                                          copy Nt seq
                                          • SLNWT_RS23645
                                          • WP_040253458.1
                                          		 5994639 - 5994974 (+) 4Fe-4S ferredoxin
                                            copy AA seq
                                            copy Nt seq
                                            • SLNWT_RS23650
                                            • WP_040253460.1
                                            		 5994974 - 5996893 (+) hypothetical protein
                                              copy AA seq
                                              copy Nt seq
                                              • SLNWT_RS23655
                                              • WP_078845181.1
                                              		 5996899 - 5998338 (+) amidase
                                                copy AA seq
                                                copy Nt seq
                                                • SLNWT_RS23660
                                                • WP_040253462.1
                                                		 5998341 - 5999852 (+) glutamine synthetase
                                                  copy AA seq
                                                  copy Nt seq
                                                  • SLNWT_RS23665
                                                  • WP_040253465.1
                                                  • purB
                                                  		 5999922 - 6001208 (+) adenylosuccinate lyase
                                                    copy AA seq
                                                    copy Nt seq
                                                    • SLNWT_RS23670
                                                    • WP_040253467.1
                                                    		 6001192 - 6001596 (+) N-acetyltransferase
                                                      copy AA seq
                                                      copy Nt seq
                                                      • SLNWT_RS23675
                                                      • WP_237282926.1
                                                      		 6001682 - 6002410 (-) DNA-binding response regulator
                                                        copy AA seq
                                                        copy Nt seq
                                                        • SLNWT_RS23680
                                                        • WP_040253470.1
                                                        		 6002701 - 6003597 (-) RNA-polymerase sigma-70 factor
                                                          copy AA seq
                                                          copy Nt seq
                                                          • SLNWT_RS23685
                                                          • WP_159393028.1
                                                          		 6004055 - 6005074 (+) transcriptional regulator protein
                                                            copy AA seq
                                                            copy Nt seq
                                                            • SLNWT_RS23690
                                                            • WP_052482559.1
                                                            		 6005741 - 6006907 (+) myo-inositol-1-phosphate synthase
                                                              copy AA seq
                                                              copy Nt seq
                                                              • SLNWT_RS23695
                                                              • WP_040253473.1
                                                              		 6006904 - 6007830 (+) xylose isomerase
                                                                copy AA seq
                                                                copy Nt seq
                                                                • SLNWT_RS23700
                                                                • WP_078845184.1
                                                                		 6007827 - 6008774 (+) sugar phosphate isomerase/epimerase family protein
                                                                  copy AA seq
                                                                  copy Nt seq
                                                                  • SLNWT_RS23705
                                                                  • WP_186095464.1
                                                                  		 6008784 - 6009470 (+) hypothetical protein
                                                                    copy AA seq
                                                                    copy Nt seq
                                                                    • SLNWT_RS23710
                                                                    • WP_040253475.1
                                                                    		 6009470 - 6010318 (+) hydrolase TatD
                                                                      copy AA seq
                                                                      copy Nt seq
                                                                      • SLNWT_RS23715
                                                                      • WP_040253477.1
                                                                      • eboE
                                                                      		 6010322 - 6011491 (+) xylose isomerase
                                                                        copy AA seq
                                                                        copy Nt seq
                                                                        • SLNWT_RS23720
                                                                        • WP_040253479.1
                                                                        		 6011488 - 6012888 (+) alkaline phosphatase family protein
                                                                          copy AA seq
                                                                          copy Nt seq
                                                                          • SLNWT_RS23725
                                                                          • WP_040253481.1
                                                                          		 6012893 - 6013447 (-) GNAT family N-acetyltransferase
                                                                            copy AA seq
                                                                            copy Nt seq
                                                                            • SLNWT_RS23730
                                                                            • WP_163011131.1
                                                                            		 6013526 - 6014176 (+) TetR family transcriptional regulator
                                                                              copy AA seq
                                                                              copy Nt seq
                                                                              • SLNWT_RS23735
                                                                              • WP_078845185.1
                                                                              		 6014222 - 6015310 (-) hydroxyneurosporene methyltransferase
                                                                                copy AA seq
                                                                                copy Nt seq
                                                                                • SLNWT_RS23740
                                                                                • WP_159393029.1
                                                                                		 6015777 - 6016853 (+) ScyD/ScyE family protein
                                                                                  copy AA seq
                                                                                  copy Nt seq
                                                                                  • SLNWT_RS37105
                                                                                  • WP_040253485.1
                                                                                  		 6017365 - 6017949 (+) cupin domain-containing protein
                                                                                    copy AA seq
                                                                                    copy Nt seq
                                                                                    • SLNWT_RS23750
                                                                                    • WP_063778692.1
                                                                                    		 6018006 - 6019868 (+) drug resistance transporter EmrB/QacA subfamily
                                                                                      copy AA seq
                                                                                      copy Nt seq
                                                                                      • SLNWT_RS23755
                                                                                      • WP_040253488.1
                                                                                      		 6020264 - 6020749 (+) hypothetical protein
                                                                                        copy AA seq
                                                                                        copy Nt seq
                                                                                        Biosynthesis information

                                                                                        Biosynthetic paths

                                                                                        prekinamycin
                                                                                        Show structure
                                                                                        Pathway: [fluo9/fluo10/fluo11] > fluo12 > [fluo8/fluo13] > fluo14 > fluo15 > [fluo5/fluo6] > [fluo21/fluo22/fluo23/fluo24/fluo25/fluo26] [1]
                                                                                        Precursor
                                                                                        Annotation changelog

                                                                                        Entry version: next

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2024-05-14
                                                                                        MIBiG v4 annotathon
                                                                                        • (ID: SJG3CBEHSM6A3I74YXLH6GLA)
                                                                                        • (ID: HSOJFFPY5IUT4HBQLSN7DGJX)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                        Entry version: 2

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2019-10-16
                                                                                        Migrated from v1.4
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                        Entry version: 1

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2018-08-06
                                                                                        Submitted
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        Detailed domain annotation
                                                                                        Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                                                        A domain glossary is available here, and an explanation of the visualisation is available here.
                                                                                        Selected features only
                                                                                        Show module domains
                                                                                        Similar known gene clusters from MIBiG 4.0
                                                                                        Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                                                        Click on reference genes to show details of similarities to genes within the current region.
                                                                                        Click on an accession to open that entry in the MiBIG database.