BGC0001596 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001596 (Streptomyces albus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	74,291	High	fluostatin M/fluostatin N/fluostatin O/fluostatin P/fluostatin Q	PKS:Type II aromatic

BGC0001596 - Region 1 - T2PKS

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Location: 1 - 74,291 nt. (total: 74,291 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 74,292
Label		BGC0001596

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

SLNWT_RS23565: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

SLNWT_RS23600: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

SLNWT_RS23610: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

SLNWT_RS23615: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Transferases: PPTase acetyltransferase methyltransferase transferase

SLNWT_RS23625: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

SLNWT_RS23630: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

SLNWT_RS23725: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

SLNWT_RS23735: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Hydrolases: amidase

SLNWT_RS23655: amidase

smcogs: SMCOG1105: amidase

Lyases: cyclase lyase

SLNWT_RS23580: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

SLNWT_RS23605: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

SLNWT_RS23665: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: synthase

SLNWT_RS23585: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

SLNWT_RS23590: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001596.3	0.99	PKS	fluostatin M, fluostatin N, fluostatin O, fluostatin P, fluostatin Q	Streptomyces albus
BGC0000231.5	0.84	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.78	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002047.2	0.66	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0001723.5	0.65	PKS	oviedomycin	Streptomyces antibioticus
BGC0000236.5	0.64	PKS	kinamycin	Streptomyces murayamaensis
BGC0000235.5	0.58	PKS	kiamycin	Streptomyces sp. W007
BGC0002276.2	0.58	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000253.4	0.58	PKS	oviedomycin	Streptomyces antibioticus
BGC0001197.5	0.57	PKS	frankiamicin	Frankia sp. EAN1pec

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001596.3	1.00	PKS	fluostatin M, fluostatin N, fluostatin O, fluostatin P, fluostatin Q	Streptomyces albus
BGC0000231.5	0.84	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.78	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002047.2	0.66	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0001723.5	0.65	PKS	oviedomycin	Streptomyces antibioticus
BGC0000235.5	0.59	PKS	kiamycin	Streptomyces sp. W007
BGC0000253.4	0.58	PKS	oviedomycin	Streptomyces antibioticus
BGC0002276.2	0.58	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001197.5	0.57	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001895.4	0.57	PKS	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 72483
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 709.5; E-value: 2.4e-216)
Product class(es):: angucycline
Product molecular weight(s):: acetyl-CoA_8: 396 Da
acetyl-CoA_9: 438 Da

SLNWT_RS23565: OXY (Score: 501.7; E-value: 5.3e-153)
SLNWT_RS23580: CYC C4-C17/C2-C19 (Score: 196.7; E-value: 8.3e-61)
SLNWT_RS23585: KS (Score: 782.7; E-value: 1.8e-238)
SLNWT_RS23590: CLF 8|9 (Score: 709.5; E-value: 2.4e-216)
SLNWT_RS23595: ACP (Score: 133.6; E-value: 4.3e-42)
SLNWT_RS23600: KR C9 (Score: 473.5; E-value: 3.7e-145)
SLNWT_RS23605: CYC C7-C12 (Score: 476.4; E-value: 6.9e-146)
SLNWT_RS23610: OXY (Score: 551.4; E-value: 4.3e-168)
SLNWT_RS23615: OXY (Score: 546.1; E-value: 1.8e-166)
SLNWT_RS23735: MET (Score: 268.6; E-value: 1.8e-82)