BGC0001631: kasumigamide biosynthetic gene cluster from Microcystis aeruginosa NIES-87
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Location: 1 - 26,273 nt. (total: 26,273 nt).
This entry is originally from NCBI GenBank LC160291.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001631
Short description kasumigamide biosynthetic gene cluster from Microcystis aeruginosa NIES-87
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
LC160291.1
via
Compounds
  • kasumigamide
Species Microcystis aeruginosa NIES-87 [taxonomy]
References
Chemical products information
kasumigamide Evidence:
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C40H50N8O9
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAW32331.1
  • ORFM1
 1 - 198 (+) transferase
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    • BAW32332.1
    • makasA
    		 1285 - 5337 (+) nonribosomal peptide synthetase
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      • BAW32333.1
      • makasB
      		 5348 - 11731 (+) nonribosomal peptide synthetase
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        • BAW32334.1
        • makasC
        		 11728 - 24075 (+) hybrid cis-AT polyketide synthase - nonribosomal peptide synthetase
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          • BAW32335.1
          • makasD
          		 24134 - 25735 (+) hydroxylase
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            • BAW32336.1
            • ORFM2
            		 25908 - >26237 (-) transferase
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              Biosynthesis information

              Biosynthetic modules

              Name
              Unk01
              Type
              nrps-type1
              Genes
              makasA
              Substrates
              phenylpyruvic acid (evidence: ATP-PPi exchange assay, Structure-based inference)
              Integrated Monomers
              Domains
              adenylation
              Name
              Unk02
              Type
              nrps-type1
              Genes
              makasB
              Substrates
              beta-alanine (evidence: ATP-PPi exchange assay, Structure-based inference)
              Integrated Monomers
              Domains
              adenylation
              Name
              Unk03
              Type
              nrps-type1
              Genes
              makasB
              Substrates
              tryptophan (evidence: ATP-PPi exchange assay, Structure-based inference)
              Integrated Monomers
              Domains
              adenylation
              Name
              Unk04
              Type
              nrps-type1
              Genes
              makasC
              Substrates
              arginine (evidence: ATP-PPi exchange assay, Structure-based inference)
              Integrated Monomers
              Domains
              adenylation
              Name
              Unk05
              Type
              nrps-type1
              Genes
              makasC
              Substrates
              R-beta-hydroxyphenylalanine, phenylalanine, D-phenylalanine (evidence: ATP-PPi exchange assay, Structure-based inference)
              Integrated Monomers
              Domains
              adenylation
              Annotation changelog

              Entry version: 3

              Date
              Changes
              Submitters
              Reviewers
              2022-09-15
              Added NRP substrate specificities
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 2

              Date
              Changes
              Submitters
              Reviewers
              2019-10-16
              Migrated from v1.4
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 1

              Date
              Changes
              Submitters
              Reviewers
              2018-08-06
              Submitted
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              Detailed domain annotation
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