BGC0001665 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001665 (Mycobacterium marinum M)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,T3PKS	1	19,519	apoptolidin	Polyketide	10%

BGC0001665 - Region 1 - T1PKS,T3PKS

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Location: 1 - 19,519 nt. (total: 19,519 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 19,520
Label		BGC0001665

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001665.1	1.77	Polyketide	methylated alkyl-resorcinol, methylated acyl-phloroglucinol	Mycobacterium marinum M
BGC0000041.1	0.66	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000282.1	0.65	Polyketide	alkylresorcinol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001310.1	0.64	Terpene	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0001257.1	0.58	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001906.1	0.57	Polyketide	naphthalene	Daldinia eschscholzii IFB-TL01
BGC0000156.1	0.57	Polyketide	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger
BGC0000107.1	0.57	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001265.1	0.57	Polyketide	melanin	Bipolaris oryzae
BGC0001284.1	0.56	Terpene	alternariol	Parastagonospora nodorum SN15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001665.1	0.96	Polyketide	methylated alkyl-resorcinol, methylated acyl-phloroglucinol	Mycobacterium marinum M
BGC0000041.1	0.66	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000282.1	0.66	Polyketide	alkylresorcinol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001310.1	0.65	Terpene	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0001257.1	0.63	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001906.1	0.62	Polyketide	naphthalene	Daldinia eschscholzii IFB-TL01
BGC0000156.1	0.62	Polyketide	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger
BGC0000107.1	0.62	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001265.1	0.62	Polyketide	melanin	Bipolaris oryzae
BGC0001284.1	0.62	Terpene	alternariol	Parastagonospora nodorum SN15

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 19519:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (redmal) + (Me-redmal)
Non-colinear ordering:: MMAR_2473 + MMAR_2472 + MMAR_2471

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

MMAR_2471

PKS_AT (565..863): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 208.0
Ethylmalonyl-CoA: 200.0
Methoxymalonyl-CoA: 173.7
2-Methylbutyryl-CoA: 146.4
trans-1,2-CPDA: 125.2
Propionyl-CoA: 121.4
Malonyl-CoA: 110.7
CHC-CoA: 95.1
Isobutyryl-CoA: 92.6
Benzoyl-CoA: 78.5
Acetyl-CoA: 56.3
inactive: 47.5
3-Methylbutyryl-CoA: 46.4
fatty_acid: 40.7

MMAR_2472

PKS_AT (560..846): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 187.0
inactive: 96.8
Methoxymalonyl-CoA: 84.2
Methylmalonyl-CoA: 70.8
Propionyl-CoA: 45.7
Ethylmalonyl-CoA: 38.5
Isobutyryl-CoA: 36.3
trans-1,2-CPDA: 33.2
fatty_acid: 32.5
Benzoyl-CoA: 28.8
2-Methylbutyryl-CoA: 27.9
Acetyl-CoA: 25.7
CHC-CoA: 25.4
3-Methylbutyryl-CoA: 0.0

MMAR_2473

PKS_AT (520..796): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Methylmalonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 166.9
inactive: 81.4
Methoxymalonyl-CoA: 78.0
Methylmalonyl-CoA: 63.0
Propionyl-CoA: 39.7
Ethylmalonyl-CoA: 30.2
trans-1,2-CPDA: 28.0
Isobutyryl-CoA: 27.9
Benzoyl-CoA: 26.2
CHC-CoA: 24.6
fatty_acid: 21.1
2-Methylbutyryl-CoA: 19.2
Acetyl-CoA: 15.8
3-Methylbutyryl-CoA: 0.0