BGC0001670 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001670 (Streptomyces virginiae)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	88,860	Medium	monensin	PKS

BGC0001670 - Region 1 - T1PKS

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Location: 1 - 88,860 nt. (total: 88,860 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 88,861
Label		BGC0001670

Tailoring functions

Oxidoreductases: oxygenase

monCI: monooxygenase FAD-binding

smcogs: SMCOG1246: monooxygenase FAD-binding

monD: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: methyltransferase

monE: methyltransferase

smcogs: SMCOG1089: methyltransferase

Hydrolases: dehalogenase esterase

monAIX: thioesterase

smcogs: SMCOG1004: thioesterase

monAX: thioesterase

smcogs: SMCOG1004: thioesterase

monCII: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

Ligases: synthase

monAII: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

monAIII: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

monAIV: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

monAV: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

monAVI: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

monAVII: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

monAVIII: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001670.5	1.00	PKS	monensin	Streptomyces cinnamonensis
BGC0000100.5	0.97	PKS	monensin	Streptomyces cinnamonensis
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000084.5	0.74	PKS	laidlomycin	Streptomyces sp. CS684
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0000107.3	0.66	PKS	naphthopyrone	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001670.5	1.00	PKS	monensin	Streptomyces cinnamonensis
BGC0000100.5	0.97	PKS	monensin	Streptomyces cinnamonensis
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000084.5	0.74	PKS	laidlomycin	Streptomyces sp. CS684
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0000107.3	0.66	PKS	naphthopyrone	Aspergillus nidulans FGSC A4

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 88860:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-ccmal) + (Me-redmal) + (ccmal - Me-redmal) + (ccemal - redmal) + (Me-ccmal - redmal) + (ohmal) + (Me-ohmal) + (Me-ohmal - Me-ccmal)
Non-colinear ordering:: monAI + monAII + monAIII + monAIV + monAV + monAVI + monAVII + monAVIII

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

monAI: mal - mmal

PKS_AT (553..877): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 91.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 187.6
inactive: 95.8
Methoxymalonyl-CoA: 64.0
Methylmalonyl-CoA: 50.6
Propionyl-CoA: 32.8
Acetyl-CoA: 31.1
Isobutyryl-CoA: 26.0
Ethylmalonyl-CoA: 21.0
Benzoyl-CoA: 10.2
3-Methylbutyryl-CoA: 10.0
trans-1,2-CPDA: 4.8
fatty_acid: 4.3
2-Methylbutyryl-CoA: 4.1
CHC-CoA: 0.1

PKS_AT (1616..1909): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 201.7
Ethylmalonyl-CoA: 193.1
Methoxymalonyl-CoA: 164.6
2-Methylbutyryl-CoA: 133.5
trans-1,2-CPDA: 122.6
Propionyl-CoA: 114.8
Malonyl-CoA: 99.2
CHC-CoA: 97.1
Isobutyryl-CoA: 70.9
Benzoyl-CoA: 59.3
Acetyl-CoA: 47.3
fatty_acid: 46.8
3-Methylbutyryl-CoA: 31.7
inactive: 26.3

monAII: mmal

PKS_AT (565..860): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 190.9
Ethylmalonyl-CoA: 188.6
Methoxymalonyl-CoA: 146.1
2-Methylbutyryl-CoA: 116.4
trans-1,2-CPDA: 112.5
Propionyl-CoA: 111.5
CHC-CoA: 110.3
Malonyl-CoA: 83.7
Isobutyryl-CoA: 66.0
fatty_acid: 42.6
Benzoyl-CoA: 41.7
Acetyl-CoA: 37.8
3-Methylbutyryl-CoA: 24.2
inactive: 18.7

monAIII: mal - mmal

PKS_AT (609..912): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 227.9
inactive: 119.5
Methoxymalonyl-CoA: 64.9
Methylmalonyl-CoA: 58.8
Isobutyryl-CoA: 32.2
Propionyl-CoA: 30.0
Benzoyl-CoA: 21.5
Ethylmalonyl-CoA: 18.1
Acetyl-CoA: 18.1
2-Methylbutyryl-CoA: 15.9
CHC-CoA: 10.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2508..2803): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 191.0
Ethylmalonyl-CoA: 188.5
Methoxymalonyl-CoA: 145.6
2-Methylbutyryl-CoA: 116.8
trans-1,2-CPDA: 113.8
Propionyl-CoA: 111.9
CHC-CoA: 111.4
Malonyl-CoA: 81.9
Isobutyryl-CoA: 68.2
fatty_acid: 44.2
Benzoyl-CoA: 43.5
Acetyl-CoA: 39.6
3-Methylbutyryl-CoA: 25.5
inactive: 17.8

monAIV: emal - mal

PKS_AT (594..889): emal

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Methylmalonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 229.3
Methylmalonyl-CoA: 189.3
Methoxymalonyl-CoA: 157.9
2-Methylbutyryl-CoA: 118.8
trans-1,2-CPDA: 114.9
Malonyl-CoA: 112.8
Propionyl-CoA: 102.9
CHC-CoA: 96.8
Isobutyryl-CoA: 78.9
Benzoyl-CoA: 77.3
Acetyl-CoA: 57.1
fatty_acid: 40.3
inactive: 27.6
3-Methylbutyryl-CoA: 22.9

PKS_AT (2378..2672): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 195.3
inactive: 87.3
Methoxymalonyl-CoA: 83.8
Methylmalonyl-CoA: 74.0
Propionyl-CoA: 48.6
Isobutyryl-CoA: 44.7
Ethylmalonyl-CoA: 40.1
fatty_acid: 39.5
Acetyl-CoA: 30.4
trans-1,2-CPDA: 21.9
2-Methylbutyryl-CoA: 20.1
Benzoyl-CoA: 18.3
CHC-CoA: 15.4
3-Methylbutyryl-CoA: 0.0

monAV: mmal - mal

PKS_AT (564..859): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 189.9
Ethylmalonyl-CoA: 189.6
Methoxymalonyl-CoA: 145.5
trans-1,2-CPDA: 113.7
2-Methylbutyryl-CoA: 111.5
Propionyl-CoA: 108.3
CHC-CoA: 105.4
Malonyl-CoA: 83.8
Isobutyryl-CoA: 63.7
Benzoyl-CoA: 45.8
fatty_acid: 39.5
Acetyl-CoA: 37.2
3-Methylbutyryl-CoA: 23.5
inactive: 18.2

PKS_AT (2399..2694): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.1
inactive: 97.7
Methoxymalonyl-CoA: 75.8
Methylmalonyl-CoA: 70.7
Propionyl-CoA: 44.8
Isobutyryl-CoA: 39.1
Ethylmalonyl-CoA: 36.7
Acetyl-CoA: 33.3
fatty_acid: 31.4
trans-1,2-CPDA: 20.5
Benzoyl-CoA: 17.2
CHC-CoA: 15.5
2-Methylbutyryl-CoA: 15.0
3-Methylbutyryl-CoA: 0.0

monAVI: mal

PKS_AT (583..880): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 203.5
inactive: 99.1
Methoxymalonyl-CoA: 71.7
Methylmalonyl-CoA: 66.2
Propionyl-CoA: 45.3
Isobutyryl-CoA: 36.5
Ethylmalonyl-CoA: 33.8
Acetyl-CoA: 33.4
fatty_acid: 30.5
CHC-CoA: 18.4
trans-1,2-CPDA: 18.2
Benzoyl-CoA: 17.9
2-Methylbutyryl-CoA: 16.6
3-Methylbutyryl-CoA: 0.0

monAVIII: mmal - mmal

PKS_AT (564..862): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 192.4
Ethylmalonyl-CoA: 185.2
Methoxymalonyl-CoA: 152.8
2-Methylbutyryl-CoA: 124.3
Propionyl-CoA: 119.8
trans-1,2-CPDA: 119.0
CHC-CoA: 105.9
Malonyl-CoA: 89.5
Isobutyryl-CoA: 69.1
fatty_acid: 46.6
Benzoyl-CoA: 43.8
Acetyl-CoA: 38.5
3-Methylbutyryl-CoA: 26.4
inactive: 22.2

PKS_AT (2120..2415): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.7
Ethylmalonyl-CoA: 192.2
Methoxymalonyl-CoA: 150.6
2-Methylbutyryl-CoA: 125.9
CHC-CoA: 122.0
Propionyl-CoA: 118.6
trans-1,2-CPDA: 117.2
Malonyl-CoA: 93.2
Isobutyryl-CoA: 67.4
Benzoyl-CoA: 42.4
Acetyl-CoA: 41.7
fatty_acid: 40.2
3-Methylbutyryl-CoA: 34.1
inactive: 27.3

monAVII: mmal

PKS_AT (569..864): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 190.9
Ethylmalonyl-CoA: 188.6
Methoxymalonyl-CoA: 146.1
2-Methylbutyryl-CoA: 116.4
trans-1,2-CPDA: 112.5
Propionyl-CoA: 111.5
CHC-CoA: 110.3
Malonyl-CoA: 83.7
Isobutyryl-CoA: 66.0
fatty_acid: 42.6
Benzoyl-CoA: 41.7
Acetyl-CoA: 37.8
3-Methylbutyryl-CoA: 24.2
inactive: 18.7

Link to PARAS substrate predictor