BGC0001675 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001675 (Streptomyces griseoruber)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	67,000	High	murayaquinone	PKS

BGC0001675 - Region 1 - T2PKS

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Location: 1 - 67,000 nt. (total: 67,000 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 67,001
Label		BGC0001675

Tailoring functions

Oxidoreductases: Hydroxylation dehydrogenase oxidoreductase oxygenase

AQW35031.1: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

AQW35050.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

mrqF: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

mrqH: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

mrqM: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

mrqO1: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

mrqO2: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

mrqO5: Hydroxylation

MITE: MITE0000087Hydroxylation (identity: 62.90%)

mrqO6: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

mrqO8: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Transferases: glycosyltransferase transferase

AQW35040.1: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

AQW35041.1: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

Hydrolases: hydrolase

AQW35049.1: isochorismatase

smcogs: SMCOG1027: isochorismatase

mrqD: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Lyases: cyclase dehydratase

AQW35042.1: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

AQW35043.1: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

mrqE: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Isomerases: isomerase

AQW35048.1: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthase

AQW35033.1: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

AQW35045.1: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

AQW35046.1: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

AQW35047.1: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

AQW35054.1: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

mrqA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

mrqB: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Translocases: transport

mrqT2: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001675.5	1.00	PKS	murayaquinone	Streptomyces griseoruber
BGC0000231.5	0.68	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0002276.2	0.67	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000234.5	0.67	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.64	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0002493.3	0.62	NRPS	parabactin	Paracoccus denitrificans PD1222
BGC0001723.5	0.61	PKS	oviedomycin	Streptomyces antibioticus
BGC0000272.3	0.60	PKS	spore pigment	Streptomyces collinus
BGC0002474.2	0.60	NRPS	agrobactin	Agrobacterium tumefaciens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001675.5	1.00	PKS	murayaquinone	Streptomyces griseoruber
BGC0000231.5	0.68	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0002276.2	0.67	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000234.5	0.67	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.64	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0002493.3	0.62	NRPS	parabactin	Paracoccus denitrificans PD1222
BGC0001723.5	0.61	PKS	oviedomycin	Streptomyces antibioticus
BGC0000272.3	0.61	PKS	spore pigment	Streptomyces collinus
BGC0002474.2	0.60	NRPS	agrobactin	Agrobacterium tumefaciens

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

AQW35047.1: NH2

CAL_domain (40..482): NH2

minowa: NH2

Prediction, score:

NH2: 111.0
Acetyl-CoA: 37.3
fatty_acid: 21.3
AHBA: 0.1
shikimic_acid: 0.0

AQW35054.1: X

AMP-binding (19..429): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: SRMEVSFPLK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 9936 to 67000
Starter unit(s):: hexanoyl-CoA (Score: 345.0; E-value: 3.87e-122)
Malonyl elongations:: 8|9 (Score: 678.7; E-value: 5.3e-207)
Product molecular weight(s):: hexanoyl-CoA_8: 639 Da
hexanoyl-CoA_9: 681 Da

AQW35035.1: OXY (Score: 31.1; E-value: 2.9e-10)
AQW35041.1: GT (Score: 315.6; E-value: 1.5e-96)
AQW35046.1: KSIII (Score: 339.9; E-value: 3.5e-104); KSIII CAM58805.1_Benastatin_hexanoyl-CoA (Score: 345.0; E-value: 3.87e-122)
AQW35050.1: KR (Score: 172.6; E-value: 2.8e-53)
mrqA: KS (Score: 776.4; E-value: 1.4e-236)
mrqB: CLF 8|9 (Score: 678.7; E-value: 5.3e-207)
mrqC: ACP (Score: 98.3; E-value: 4.5e-31)
mrqD: CYC C5-C14 (Score: 436.8; E-value: 8.3e-134)
mrqE: CYC C7-C12 (Score: 480.0; E-value: 5.6e-147)
mrqF: KR C9 (Score: 455.2; E-value: 1.4e-139)
mrqH: KR (Score: 222.9; E-value: 1.3e-68)
mrqK: CYC C1-C18|C2-C19 (Score: 180.0; E-value: 4.8e-56)
mrqM: KR (Score: 192.5; E-value: 2.4e-59)
mrqO3: OXY (Score: 13.4; E-value: 6.7e-05)
mrqO6: OXY (Score: 206.6; E-value: 1.7e-63)
mrqO8: OXY (Score: 177.1; E-value: 1.5e-54)