BGC0001705: nodularin biosynthetic gene cluster from Nostoc sp. CENA543
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Location: 1 - 48,240 nt. (total: 48,240 nt).
This entry is originally from NCBI GenBank MF668122.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001705
Short description nodularin biosynthetic gene cluster from Nostoc sp. CENA543
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
MF668122.1
via
Compounds
  • nodularin
Species Nostoc sp. CENA543 [taxonomy]
References
Chemical products information
nodularin Evidence:
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C41H60N8O10
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ATP76236.1
  • ndaI
 1 - 1821 (-) NdaI
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    • ATP76237.1
    • ndaH
    		 2222 - 3232 (-) NdaH
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      • ATP76238.1
      • ndaG
      		 3244 - 4041 (-) NdaG
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        • ATP76239.1
        • ndaF
        		 4083 - 14534 (-) NdaF
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          • ATP76240.1
          • ndaE
          		 14571 - 15500 (-) NdaE
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            • ATP76241.1
            • ndaD
            		 15563 - 27274 (-) NdaD
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              • ATP76242.1
              • ndaC
              		 27314 - 35272 (-) NdaC
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                • ATP76243.1
                • ndaA
                		 36499 - 44382 (+) NdaA
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                  • ATP76244.1
                  • ndaB
                  		 44386 - 48240 (+) NdaB
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                    Biosynthesis information

                    Biosynthetic modules

                    Name
                    Unk01
                    Type
                    nrps-type1
                    Genes
                    ndaF
                    Substrates
                    glutamic acid (evidence: Structure-based inference, Sequence-based prediction, Mass spectrometry)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk02
                    Type
                    nrps-type1
                    Genes
                    ndaA
                    Substrates
                    threonine (evidence: Structure-based inference, Sequence-based prediction, Mass spectrometry)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk03
                    Type
                    nrps-type1
                    Genes
                    ndaA
                    Substrates
                    3R-methyl-D-aspartic acid branched (evidence: Structure-based inference, Sequence-based prediction, Mass spectrometry)
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk04
                    Type
                    nrps-type1
                    Genes
                    ndaB
                    Substrates
                    arginine (evidence: Structure-based inference, Sequence-based prediction, Mass spectrometry)
                    Integrated Monomers
                    Domains
                    adenylation
                    Annotation changelog

                    Entry version: 3

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-09-15
                    Added NRP substrate specificities
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 2

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2019-10-16
                    Migrated from v1.4
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 1

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2018-08-06
                    Submitted
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    Detailed domain annotation
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