BGC0001719 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001719 (Streptomyces olivaceus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,2dos	1	74,495	olimycin A/olimycin B	PKS	100%

BGC0001719 - Region 1 - 2dos,T1PKS

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Location: 1 - 74,495 nt. (total: 74,495 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
2dos: ((DOIS or DHQ_synthase or ValA or salQ) and DegT_DnrJ_EryC1 and (LipV or ADSI-DH or cds(ADH_N and ADH_zinc_N)))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 74,496
Label		BGC0001719

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001719	1.61	Polyketide	olimycin A, olimycin B	Streptomyces olivaceus
BGC0001119	1.03	Polyketide	divergolide A, divergolide B, divergolide C, divergolide D	Streptomyces sp. HKI0576
BGC0001273	0.71	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000018	0.71	Polyketide	angolamycin	Streptomyces eurythermus
BGC0001163	0.71	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001749	0.70	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0001276	0.68	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275	0.67	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244	0.66	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001164	0.66	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001719	1.00	Polyketide	olimycin A, olimycin B	Streptomyces olivaceus
BGC0001119	0.88	Polyketide	divergolide A, divergolide B, divergolide C, divergolide D	Streptomyces sp. HKI0576
BGC0001749	0.69	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0001273	0.68	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001163	0.68	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001276	0.67	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0000067	0.67	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001275	0.67	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000996	0.67	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0001068	0.66	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 74339:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal) + (Me-mal - ccmal) + (mal - ohmal) + (redemal) + (ccmal) + (pk)
Non-colinear ordering:: QIE07124.1 + QIE07125.1 + QIE07131.1 + QIE07126.1 + QIE07127.1 + QIE07128.1 + QIE07129.1 + QIE07130.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

QIE07123.1

CAL_domain (35..439): pk

minowa: AHBA

Prediction, score:

AHBA: 389.9
shikimic_acid: 243.8
fatty_acid: 0.0
NH2: 0.0
Acetyl-CoA: 0.0

QIE07124.1

PKS_AT (712..1010): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 205.8
Ethylmalonyl-CoA: 191.9
Methoxymalonyl-CoA: 175.6
2-Methylbutyryl-CoA: 123.9
trans-1,2-CPDA: 119.0
Malonyl-CoA: 105.3
Propionyl-CoA: 99.2
CHC-CoA: 87.7
Isobutyryl-CoA: 80.8
Benzoyl-CoA: 64.6
Acetyl-CoA: 45.1
inactive: 33.9
3-Methylbutyryl-CoA: 24.0
fatty_acid: 19.5

QIE07126.1

PKS_AT (518..807): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.7
inactive: 105.2
Methoxymalonyl-CoA: 60.0
Methylmalonyl-CoA: 36.4
Propionyl-CoA: 31.0
Acetyl-CoA: 16.2
2-Methylbutyryl-CoA: 12.1
Benzoyl-CoA: 8.6
Ethylmalonyl-CoA: 7.0
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
Isobutyryl-CoA: -2.3

PKS_AT (1548..1837): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.1
inactive: 115.7
Methoxymalonyl-CoA: 67.1
Methylmalonyl-CoA: 44.6
Propionyl-CoA: 31.0
Isobutyryl-CoA: 21.4
2-Methylbutyryl-CoA: 20.3
Acetyl-CoA: 16.9
3-Methylbutyryl-CoA: 14.3
Benzoyl-CoA: 8.5
Ethylmalonyl-CoA: 5.0
CHC-CoA: 0.5
trans-1,2-CPDA: 0.0
fatty_acid: 0.0

QIE07127.1

PKS_AT (618..916): emal

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 83.3%; Methylmalonyl-CoA: 79.2%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 192.3
Methylmalonyl-CoA: 187.9
Methoxymalonyl-CoA: 153.0
2-Methylbutyryl-CoA: 124.0
Propionyl-CoA: 112.7
trans-1,2-CPDA: 96.3
CHC-CoA: 91.9
Malonyl-CoA: 87.0
Isobutyryl-CoA: 78.3
Acetyl-CoA: 47.6
fatty_acid: 45.2
Benzoyl-CoA: 43.4
3-Methylbutyryl-CoA: 32.7
inactive: 26.3

QIE07128.1

PKS_AT (545..834): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 62.5%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 185.8
inactive: 91.9
Methoxymalonyl-CoA: 72.8
Methylmalonyl-CoA: 66.3
Propionyl-CoA: 39.0
Isobutyryl-CoA: 35.0
Ethylmalonyl-CoA: 28.5
CHC-CoA: 14.3
Benzoyl-CoA: 13.5
Acetyl-CoA: 12.5
fatty_acid: 11.7
2-Methylbutyryl-CoA: 9.3
trans-1,2-CPDA: 8.4
3-Methylbutyryl-CoA: 6.4

QIE07129.1

PKS_AT (652..950): pk

ATSignature: Methoxymalonyl-CoA

Top 3 matches:: Methoxymalonyl-CoA: 83.3%; Methylmalonyl-CoA: 79.2%; Ethylmalonyl-CoA: 75.0%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 193.4
Methylmalonyl-CoA: 183.6
Methoxymalonyl-CoA: 153.0
2-Methylbutyryl-CoA: 135.5
Propionyl-CoA: 117.6
trans-1,2-CPDA: 101.6
Malonyl-CoA: 100.1
CHC-CoA: 94.2
Isobutyryl-CoA: 88.3
Benzoyl-CoA: 62.7
fatty_acid: 43.2
Acetyl-CoA: 42.4
3-Methylbutyryl-CoA: 38.4
inactive: 26.2

QIE07131.1

PKS_AT (567..865): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 196.5
Ethylmalonyl-CoA: 177.8
Methoxymalonyl-CoA: 150.5
trans-1,2-CPDA: 105.1
2-Methylbutyryl-CoA: 103.7
Propionyl-CoA: 85.6
Malonyl-CoA: 81.2
CHC-CoA: 76.7
Isobutyryl-CoA: 64.6
Benzoyl-CoA: 57.9
Acetyl-CoA: 47.9
fatty_acid: 31.9
inactive: 22.9
3-Methylbutyryl-CoA: 20.4

PKS_AT (1573..1872): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 181.1
inactive: 98.3
Methoxymalonyl-CoA: 68.4
Methylmalonyl-CoA: 60.8
Ethylmalonyl-CoA: 37.7
Propionyl-CoA: 31.8
Acetyl-CoA: 23.9
Isobutyryl-CoA: 19.4
CHC-CoA: 14.9
Benzoyl-CoA: 14.9
2-Methylbutyryl-CoA: 14.9
trans-1,2-CPDA: 8.7
fatty_acid: 7.3
3-Methylbutyryl-CoA: 0.0