BGC0001742 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001742 (Candidatus Streptomyces philanthi bv. triangulum)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	50,415	High	piericidin A1	PKS:Type I

BGC0001742 - Region 1 - T1PKS

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Location: 1 - 50,415 nt. (total: 50,415 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 50,416
Label		BGC0001742

Tailoring functions

Oxidoreductases: oxygenase

CSP_7457: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Transferases: acylase methyltransferase

CSP_7458: methyltransferase

smcogs: SMCOG1089: methyltransferase

CSP_7464: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase

CSP_7459: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Ligases: synthase

CSP_7462: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

CSP_7463: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

CSP_7466: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

CSP_7467: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

CSP_7468: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001742.5	1.00	PKS	piericidin A1	Candidatus Streptomyces philanthi bv. triangulum
BGC0000124.5	0.78	PKS	piericidin A1	Streptomyces piomogenus
BGC0001275.3	0.77	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.77	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001169.5	0.75	PKS	piericidin A1	Streptomyces sp. SCSIO 03032
BGC0000041.3	0.70	PKS	oronofacic acid	Pseudomonas syringae
BGC0002154.2	0.67	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001742.5	1.00	PKS	piericidin A1	Candidatus Streptomyces philanthi bv. triangulum
BGC0000124.5	0.78	PKS	piericidin A1	Streptomyces piomogenus
BGC0001275.3	0.77	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.77	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001169.5	0.75	PKS	piericidin A1	Streptomyces sp. SCSIO 03032
BGC0000041.3	0.70	PKS	oronofacic acid	Pseudomonas syringae
BGC0002154.2	0.67	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 50415:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - Me-ccmal) + (Me-ohmal - Me-ccmal) + (Me-redmal) + (ccmal) + (Me-mal - mal)
Non-colinear ordering:: CSP_7468 + CSP_7467 + CSP_7464 + CSP_7463 + CSP_7462

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CSP_7468: mmal - mmal

PKS_AT (359..659): mmal

ATSignature: 2-Methylbutyryl-CoA

Top 3 matches:: 2-Methylbutyryl-CoA: 83.3%; Isobutyryl-CoA: 66.7%; Methylmalonyl-CoA: 66.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 162.1
Ethylmalonyl-CoA: 161.8
2-Methylbutyryl-CoA: 141.6
Methoxymalonyl-CoA: 125.9
Propionyl-CoA: 125.2
trans-1,2-CPDA: 110.6
CHC-CoA: 100.6
Malonyl-CoA: 56.2
Isobutyryl-CoA: 48.6
Benzoyl-CoA: 32.5
Acetyl-CoA: 26.2
3-Methylbutyryl-CoA: 26.1
fatty_acid: 21.6
inactive: 0.0

PKS_AT (1363..1658): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.7
Ethylmalonyl-CoA: 196.1
Methoxymalonyl-CoA: 166.6
2-Methylbutyryl-CoA: 133.2
trans-1,2-CPDA: 125.3
CHC-CoA: 103.2
Propionyl-CoA: 100.8
Malonyl-CoA: 99.3
Isobutyryl-CoA: 81.9
Benzoyl-CoA: 70.1
Acetyl-CoA: 43.9
3-Methylbutyryl-CoA: 30.3
inactive: 20.1
fatty_acid: 17.5

CSP_7467: mmal - mmal

PKS_AT (567..862): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.7
Ethylmalonyl-CoA: 196.1
Methoxymalonyl-CoA: 166.6
2-Methylbutyryl-CoA: 133.2
trans-1,2-CPDA: 125.3
CHC-CoA: 103.2
Propionyl-CoA: 100.8
Malonyl-CoA: 99.3
Isobutyryl-CoA: 81.9
Benzoyl-CoA: 70.1
Acetyl-CoA: 43.9
3-Methylbutyryl-CoA: 30.3
inactive: 20.1
fatty_acid: 17.5

PKS_AT (2141..2436): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.7
Ethylmalonyl-CoA: 196.1
Methoxymalonyl-CoA: 166.6
2-Methylbutyryl-CoA: 133.2
trans-1,2-CPDA: 125.3
CHC-CoA: 103.2
Propionyl-CoA: 100.8
Malonyl-CoA: 99.3
Isobutyryl-CoA: 81.9
Benzoyl-CoA: 70.1
Acetyl-CoA: 43.9
3-Methylbutyryl-CoA: 30.3
inactive: 20.1
fatty_acid: 17.5

CSP_7464: mmal

PKS_AT (543..838): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.7
Ethylmalonyl-CoA: 196.1
Methoxymalonyl-CoA: 166.6
2-Methylbutyryl-CoA: 133.2
trans-1,2-CPDA: 125.3
CHC-CoA: 103.2
Propionyl-CoA: 100.8
Malonyl-CoA: 99.3
Isobutyryl-CoA: 81.9
Benzoyl-CoA: 70.1
Acetyl-CoA: 43.9
3-Methylbutyryl-CoA: 30.3
inactive: 20.1
fatty_acid: 17.5

CSP_7463: mal

PKS_AT (610..901): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 79.2%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 201.1
inactive: 97.8
Methoxymalonyl-CoA: 53.6
Methylmalonyl-CoA: 51.8
Propionyl-CoA: 35.9
Benzoyl-CoA: 25.5
Isobutyryl-CoA: 24.4
Ethylmalonyl-CoA: 14.6
2-Methylbutyryl-CoA: 12.9
fatty_acid: 10.3
Acetyl-CoA: 8.5
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

CSP_7462: mmal - mal

PKS_AT (568..863): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.7
Ethylmalonyl-CoA: 196.1
Methoxymalonyl-CoA: 166.6
2-Methylbutyryl-CoA: 133.2
trans-1,2-CPDA: 125.3
CHC-CoA: 103.2
Propionyl-CoA: 100.8
Malonyl-CoA: 99.3
Isobutyryl-CoA: 81.9
Benzoyl-CoA: 70.1
Acetyl-CoA: 43.9
3-Methylbutyryl-CoA: 30.3
inactive: 20.1
fatty_acid: 17.5

PKS_AT (1606..1904): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 180.0
inactive: 95.3
Methylmalonyl-CoA: 46.8
Methoxymalonyl-CoA: 46.7
Propionyl-CoA: 21.7
Acetyl-CoA: 14.4
Ethylmalonyl-CoA: 12.1
fatty_acid: 11.6
Benzoyl-CoA: 9.7
CHC-CoA: 7.3
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor