BGC0001750: pyrronazol B biosynthetic gene cluster from Nannocystis pusilla
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Location: 1 - 38,255 nt. (total: 38,255 nt).
This entry is originally from NCBI GenBank MF817819.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001750
Short description pyrronazol B biosynthetic gene cluster from Nannocystis pusilla
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
MF817819.1
via
Compounds
  • pyrronazol B
Species Nannocystis pusilla [taxonomy]
References
Chemical products information
pyrronazol B Evidence:
Copy SMILES
C17H17Cl1N2O4
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ATG32069.1
  • pynA
 1 - 726 (-) methyltransferase
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    • ATG32070.1
    • pynB
    		 908 - 2050 (+) proline dehydrogenase
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      • ATG32071.1
      • pynC
      		 2053 - 3564 (+) proline specific adenylation domain-containing protein
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        • ATG32072.1
        • pynD
        		 3561 - 3815 (+) acyl carrier protein
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          • ATG32073.1
          • pynE
          		 3904 - 5250 (+) FADH2/O2 dependent halogenase
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            • ATG32074.1
            • pynF
            		 5271 - 7466 (+) putative nonfunctional polyketide synthase module
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              • ATG32075.1
              • pynG
              		 7463 - 13003 (+) polyketide synthase
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                • ATG32076.1
                • pynH
                		 13000 - 17190 (+) nonribosomal peptide synthetase
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                  • ATG32077.1
                  • pynI
                  		 17301 - 23150 (+) polyketide synthase
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                    • ATG32078.1
                    • pynJ
                    		 23277 - 27887 (+) polyketide synthase
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                      • ATG32079.1
                      • pynK
                      		 27884 - 28651 (+) thioesterase domain
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                        • ATG32080.1
                        • pynL
                        		 28648 - 29877 (+) cytochrome P450
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                          • ATG32081.1
                          		 29950 - 30531 (-) hypothetical protein
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                            • ATG32082.1
                            		 30543 - 31127 (-) hypothetical protein
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                              • ATG32083.1
                              		 31348 - 32184 (-) hypothetical protein
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                                • ATG32084.1
                                		 32376 - 33155 (-) NAD(P)H dehydrogenase
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                                  • ATG32085.1
                                  		 33274 - 34176 (+) LysR family transcriptional regulator
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                                    • ATG32086.1
                                    		 34216 - 34590 (+) putative enoyl-CoA hydratase
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                                      • ATG32087.1
                                      		 34775 - 35230 (-) putative polyketide cyclase
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                                        • ATG32088.1
                                        		 35626 - 36267 (+) glutathione S-transferase family protein
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                                          • ATG32089.1
                                          		 36282 - 37166 (-) AraC family transcriptional regulator
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                                            • ATG32090.1
                                            		 37356 - 38255 (+) AraC-type DNA-binding protein
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                                              Biosynthesis information

                                              Biosynthetic modules

                                              Name
                                              Unk01
                                              Type
                                              nrps-type1
                                              Genes
                                              pynC
                                              Substrates
                                              proline (evidence: Feeding study, Mass spectrometry, Homology)
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk02
                                              Type
                                              nrps-type1
                                              Genes
                                              pynH
                                              Substrates
                                              serine (evidence: Feeding study, Mass spectrometry, Homology)
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Annotation changelog

                                              Entry version: 3

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2022-09-15
                                              Added NRP substrate specificities
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 2

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2019-10-16
                                              Migrated from v1.4
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              2019-10-16
                                              Updated compound(s) information (NPAtlas curation)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 1

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2018-08-06
                                              Submitted
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              Detailed domain annotation
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