BGC0001753 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001753 (Streptomyces globisporus subsp. globisporus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	thiopeptide	1	20,652	radamycin/globimycin	ribosomal:RiPP	100%

BGC0001753 - Region 1 - thiopeptide

Download region GenBank file

Download region SVG

Location: 1 - 20,652 nt. (total: 20,652 nt) Show pHMM detection rules used

Region on contig edge.

thiopeptide: ((YcaO or TIGR03604) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

MIBiG comparison

KnownClusterBlast

Thiopeptides

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 20,653
Label		BGC0001753

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001753	0.91	RiPP	radamycin, globimycin	Streptomyces globisporus subsp. globisporus
BGC0002311	0.34	RiPP	cutimycin	Cutibacterium acnes KPA171202
BGC0000613	0.29	RiPP	thiomuracin A	Nonomuraea sp. Bp3714-39
BGC0002120	0.27	RiPP	nocathioamide A	Nocardia terpenica IFM 0706
BGC0000615	0.26	RiPP	TP-1161	Nocardiopsis sp. TFS65-07
BGC0000844	0.25	Other	clavulanic acid	Streptomyces clavuligerus
BGC0000606	0.25	RiPP	lactazole	Streptomyces lactacystinaeus
BGC0000605	0.24	RiPP	GE37468	Streptomyces sp. ATCC 55365
BGC0001201	0.24	Terpene	eremophilene	Sorangium cellulosum So ce56
BGC0002584	0.23	RiPP	azolemycin B, azolemycin A, azolemycin D, azolemycin C	Streptomyces sp. FXJ1.264

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001753	0.97	RiPP	radamycin, globimycin	Streptomyces globisporus subsp. globisporus
BGC0002311	0.67	RiPP	cutimycin	Cutibacterium acnes KPA171202
BGC0000613	0.63	RiPP	thiomuracin A	Nonomuraea sp. Bp3714-39
BGC0002120	0.61	RiPP	nocathioamide A	Nocardia terpenica IFM 0706
BGC0000615	0.59	RiPP	TP-1161	Nocardiopsis sp. TFS65-07
BGC0000844	0.58	Other	clavulanic acid	Streptomyces clavuligerus
BGC0000606	0.58	RiPP	lactazole	Streptomyces lactacystinaeus
BGC0000605	0.57	RiPP	GE37468	Streptomyces sp. ATCC 55365
BGC0001201	0.57	Terpene	eremophilene	Sorangium cellulosum So ce56
BGC0002584	0.56	RiPP	azolemycin B, azolemycin A, azolemycin D, azolemycin C	Streptomyces sp. FXJ1.264

Similar known gene clusters from MIBiG 4.0

Thiopeptide predictions

Thiopeptide(s)

IF53_RS1000000135460

Leader:

MDAVESLDLNALEISDLIEDSNYSDETLSQAMAA

Core:

STTTTGCTTSSCSSSSS

Core with dehydrations:

DhaDhbDhbDhbDhbGCysDhbDhbDhaDhaCysDhaDhaDhaDhaDha

antiSMASH-DB 4.0 matches for IF53_RS1000000135460

100.0% NZ_CP051486.1and 9 others:

NZ_CP054019.1 Thiopeptides: HRD51_RS22770_thiopeptideNZ_CP054019.1 Thiopeptides: HRD51_RS22765_thiopeptideNZ_CP070326.1 Thiopeptides: JNO44_RS24110_thiopeptideNZ_CP070326.1 Thiopeptides: JNO44_RS24105_thiopeptideNZ_CP072931.1 Thiopeptides: SU9_RS14055_thiopeptideNZ_JAPTYM010000001.1 Thiopeptides: O1M07_RS24000_thiopeptideNZ_JAPTYM010000001.1 Thiopeptides: O1M07_RS23995_thiopeptideNZ_LJSN01000005.1 Thiopeptides: AOB60_RS40645_thiopeptideNZ_LJSN01000005.1 Thiopeptides: AOB60_RS40640_thiopeptide

Thiopeptides: HED23_RS03525_thiopeptide

STTTTGCTTSSCSSSSS

MIBiG 3.1 matches for IF53_RS1000000135460

15.4% BGC0002110 (QKV49894.1): Lanthipeptide: birimositide

CTTSSCSSS

C T+ C+S

CPTTKCTSK

10.8% BGC0001229 (SBI_06989): Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTTSSCSS

C T+ C+S

CPTTKCTS

IF53_RS1000000135465

Leader:

MNSSEELDLNALEISDLIDELGRDNETLSQVMAA

Core:

SCVGTACACSSTSSSS

Core with dehydrations:

DhaCysVGDhbACysACysDhaDhaDhbDhaDhaDhaDha

antiSMASH-DB 4.0 matches for IF53_RS1000000135465

50.0% NZ_BMSO01000004.1: Thiopeptides: IE184_RS11980_thiopeptide

SCVGTACA

MIBiG 3.1 matches for IF53_RS1000000135465

18.2% BGC0000563 (AEA03263.1): Lanthipeptide: venezuelin

CVGTACA

C+G +CA

CIGISCA

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Types:

Type I: Featuring genes encoding indolic acid side ring (series e)
Type II: Featuring the gene coding for quinaldic acid moiety formation (series a, b, and c)
Type III: No genes for synthesizing L-Trp derivatives (series d)

Thiopeptides

Core peptide predictions

IF53_RS1000000135460

Putative Type III

Cleavage pHMM score: 11.70

RODEO score: 33

Monoisotopic mass: 1583.6 Da

Molecular weight: 1584.6 Da

Predicted peptide features:
Central ring: pyridine trisubstituted

Macrocycle: 29-member

Tail reaction: dealkylation of C-Terminal residue; amidation

Alternative weights: (assuming N unmodified Ser/Thr residues); 1602.6 Da N = 1; 1620.6 Da N = 2; 1638.7 Da N = 3; 1656.7 Da N = 4; 1674.7 Da N = 5; 1692.7 Da N = 6; 1710.7 Da N = 7; 1728.8 Da N = 8; 1746.8 Da N = 9; 1764.8 Da N = 10; 1782.8 Da N = 11; 1800.8 Da N = 12; 1818.9 Da N = 13; 1836.9 Da N = 14

IF53_RS1000000135465

Putative Type III

Cleavage pHMM score: 21.40

RODEO score: 28

Monoisotopic mass: 1436.5 Da

Molecular weight: 1437.5 Da

Predicted peptide features:
Central ring: pyridine trisubstituted

Tail reaction: dealkylation of C-Terminal residue; amidation

Alternative weights: (assuming N unmodified Ser/Thr residues); 1455.6 Da N = 1; 1473.6 Da N = 2; 1491.6 Da N = 3; 1509.6 Da N = 4; 1527.6 Da N = 5; 1545.7 Da N = 6; 1563.7 Da N = 7; 1581.7 Da N = 8; 1599.7 Da N = 9