BGC0001771: scleric acid biosynthetic gene cluster from Streptomyces sclerotialus
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Location: 13,255 - 31,732 nt. (total: 18,478 nt).
This entry is originally from NCBI GenBank NZ_JOBC01000043.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001771
Short description scleric acid biosynthetic gene cluster from Streptomyces sclerotialus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
NZ_JOBC01000043.1
13255 - 31732
via
Compounds
  • scleric acid
Species Streptomyces sclerotialus [taxonomy]
References
Chemical products information
scleric acid Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • IG96_RS0135470
  • WP_037773640.1
 13255 - 13881 (-) 4'-phosphopantetheinyl transferase superfamily protein
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    • IG96_RS0135475
    • WP_030624999.1
    		 13957 - 15117 (-) 2-oxo acid dehydrogenase subunit E2
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      • IG96_RS0135480
      • WP_030625001.1
      		 15114 - 16130 (-) alpha-ketoacid dehydrogenase subunit beta
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        • IG96_RS0135485
        • WP_078889003.1
        		 16127 - 17050 (-) thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha
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          • IG96_RS0135490
          • WP_030625009.1
          		 17047 - 17277 (-) acyl carrier protein
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            • IG96_RS0135495
            • WP_078889004.1
            		 17467 - 18099 (-) ScbR family autoregulator-binding transcription factor
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              • IG96_RS37875
              • WP_196943382.1
              		 18415 - 19407 (+) ScbA/BarX family gamma-butyrolactone biosynthesis protein
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                • IG96_RS0135505
                • WP_051872433.1
                		 19371 - 19691 (+) LysR family transcriptional regulator
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                  • IG96_RS0135510
                  • WP_030625021.1
                  		 19745 - 20431 (+) HAD-IB family hydrolase
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                    • IG96_RS0135515
                    • WP_051872434.1
                    		 20453 - 21043 (-) TetR/AcrR family transcriptional regulator
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                      • IG96_RS0135520
                      • WP_030625026.1
                      		 21218 - 22354 (+) acyl-CoA dehydrogenase family protein
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                        • IG96_RS37880
                        • WP_051872436.1
                        		 22635 - 25775 (+) non-ribosomal peptide synthetase
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                          • IG96_RS0135530
                          • WP_030625041.1
                          		 25772 - 26503 (+) alpha/beta fold hydrolase
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                            • IG96_RS0135535
                            • WP_051872438.1
                            		 26548 - 28518 (+) phenazine-specific anthranilate synthase
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                              • IG96_RS0135540
                              • WP_107054275.1
                              		 28530 - 29732 (+) 3-deoxy-7-phosphoheptulonate synthase
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                                • IG96_RS0135545
                                • WP_030625033.1
                                		 29754 - 30416 (+) isochorismatase family protein
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                                  • IG96_RS0135550
                                  • WP_030625035.1
                                  		 30413 - 31732 (+) peptide ligase PGM1-related protein
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                                    Biosynthesis information

                                    Biosynthetic modules

                                    Name
                                    Unk01
                                    Type
                                    nrps-type1
                                    Genes
                                    IG96_RS37880
                                    Substrates
                                    proline (evidence: Structure-based inference, Mass spectrometry)
                                    Integrated Monomers
                                    Domains
                                    adenylation
                                    Annotation changelog

                                    Entry version: 3

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2022-09-15
                                    Added NRP substrate specificities
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 2

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2019-10-16
                                    Migrated from v1.4
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 1

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2018-08-06
                                    Submitted
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    Detailed domain annotation
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