BGC0001784 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001784 (Streptomyces seoulensis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	95,952	streptoseomycin	Polyketide	100%

BGC0001784 - Region 1 - T1PKS

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Location: 1 - 95,952 nt. (total: 95,952 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 95,953
Label		BGC0001784

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001939.1	0.66	Polyketide	streptoseomycin	Streptomyces seoulensis
BGC0001784.1	0.66	Polyketide	streptoseomycin	Streptomyces seoulensis
BGC0000041.1	0.34	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001276.1	0.32	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.1	0.32	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.1	0.32	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001909.1	0.31	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000160.1	0.30	Polyketide	terreic acid	Aspergillus terreus NIH2624
BGC0000170.1	0.30	Polyketide	yanuthone D	Aspergillus niger ATCC 1015
BGC0000067.1	0.28	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001939.1	0.90	Polyketide	streptoseomycin	Streptomyces seoulensis
BGC0001784.1	0.90	Polyketide	streptoseomycin	Streptomyces seoulensis
BGC0000041.1	0.67	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001892.1	0.66	Polyketide	botcinic acid	Botrytis cinerea B05.10
BGC0001276.1	0.65	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.1	0.65	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.1	0.65	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001909.1	0.64	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000631.1	0.64	Terpene	botrydial	Botrytis cinerea B05.10
BGC0000160.1	0.64	Polyketide	terreic acid	Aspergillus terreus NIH2624

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 15830 - 95952:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk - Me-ohmal - Me-ccmal - ccmal) + (ohmal - ohmal - ccmal) + (ccmal - ccmal)
Non-colinear ordering:: AWH12936.1 + AWH12937.1 + AWH12938.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

AWH12936.1

PKS_AT (533..828): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 202.1
Methylmalonyl-CoA: 200.4
Methoxymalonyl-CoA: 161.7
2-Methylbutyryl-CoA: 131.7
Malonyl-CoA: 106.4
Propionyl-CoA: 104.8
trans-1,2-CPDA: 103.0
CHC-CoA: 99.0
Isobutyryl-CoA: 69.0
Benzoyl-CoA: 55.9
Acetyl-CoA: 40.1
inactive: 30.1
fatty_acid: 29.0
3-Methylbutyryl-CoA: 20.5

PKS_AT (1520..1815): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.7
Ethylmalonyl-CoA: 188.2
Methoxymalonyl-CoA: 159.0
2-Methylbutyryl-CoA: 130.9
trans-1,2-CPDA: 108.1
Malonyl-CoA: 95.7
Propionyl-CoA: 93.2
CHC-CoA: 92.1
Isobutyryl-CoA: 75.7
Benzoyl-CoA: 58.8
Acetyl-CoA: 38.2
fatty_acid: 30.0
inactive: 18.9
3-Methylbutyryl-CoA: 18.6

PKS_AT (3037..3328): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 203.2
Ethylmalonyl-CoA: 191.8
Methoxymalonyl-CoA: 161.8
2-Methylbutyryl-CoA: 133.7
trans-1,2-CPDA: 107.4
Malonyl-CoA: 98.7
CHC-CoA: 98.5
Propionyl-CoA: 95.2
Isobutyryl-CoA: 78.1
Benzoyl-CoA: 58.8
Acetyl-CoA: 37.6
fatty_acid: 29.4
inactive: 19.3
3-Methylbutyryl-CoA: 18.6

PKS_AT (4766..5038): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 128.2
inactive: 59.6
Methoxymalonyl-CoA: 54.6
Methylmalonyl-CoA: 40.2
Isobutyryl-CoA: 24.6
Acetyl-CoA: 24.2
Propionyl-CoA: 21.4
trans-1,2-CPDA: 9.3
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

AWH12937.1

PKS_AT (566..838): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 133.0
inactive: 61.4
Methoxymalonyl-CoA: 58.5
Methylmalonyl-CoA: 42.8
Isobutyryl-CoA: 27.1
Acetyl-CoA: 23.8
Propionyl-CoA: 22.0
trans-1,2-CPDA: 10.7
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2075..2347): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 133.0
inactive: 61.4
Methoxymalonyl-CoA: 58.5
Methylmalonyl-CoA: 42.8
Isobutyryl-CoA: 27.1
Acetyl-CoA: 23.8
Propionyl-CoA: 22.0
trans-1,2-CPDA: 10.7
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (3573..3845): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 132.2
inactive: 60.4
Methoxymalonyl-CoA: 59.3
Methylmalonyl-CoA: 42.7
Isobutyryl-CoA: 34.7
Acetyl-CoA: 23.8
Propionyl-CoA: 23.0
trans-1,2-CPDA: 10.2
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

AWH12938.1

PKS_AT (560..832): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 132.2
inactive: 60.4
Methoxymalonyl-CoA: 59.3
Methylmalonyl-CoA: 42.7
Isobutyryl-CoA: 34.7
Acetyl-CoA: 23.8
Propionyl-CoA: 23.0
trans-1,2-CPDA: 10.2
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2216..2488): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 133.0
inactive: 61.4
Methoxymalonyl-CoA: 58.5
Methylmalonyl-CoA: 42.8
Isobutyryl-CoA: 27.1
Acetyl-CoA: 23.8
Propionyl-CoA: 22.0
trans-1,2-CPDA: 10.7
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0