BGC0001787 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001787 (Streptococcus suis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	lanthipeptide-class-ii	1	13,318	High	suicin 3908	ribosomal:RiPP

BGC0001787 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 13,318 nt. (total: 13,318 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 13,319
Label		BGC0001787

Tailoring functions

Lyases: cyclase

suiM: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001787.3	1.00	ribosomal	suicin 3908	Streptococcus suis
BGC0000626.3	0.68	ribosomal	thuricin	Bacillus thuringiensis
BGC0000561.5	0.67	ribosomal	thermophilin 1277	Streptococcus thermophilus
BGC0000498.5	0.67	ribosomal	bovicin HJ50	Streptococcus equinus
BGC0001210.5	0.52	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000539.5	0.51	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000528.5	0.51	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000547.5	0.49	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000548.4	0.49	ribosomal	salivaricin A	Streptococcus salivarius
BGC0000521.3	0.49	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001787.3	1.00	ribosomal	suicin 3908	Streptococcus suis
BGC0000626.3	0.68	ribosomal	thuricin	Bacillus thuringiensis
BGC0000561.5	0.67	ribosomal	thermophilin 1277	Streptococcus thermophilus
BGC0000498.5	0.67	ribosomal	bovicin HJ50	Streptococcus equinus
BGC0001210.5	0.52	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000539.5	0.51	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000528.5	0.51	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000547.5	0.49	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000548.4	0.49	ribosomal	salivaricin A	Streptococcus salivarius
BGC0000521.3	0.49	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis

Similar known clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for suiM

suiA

Leader:

MNNIKPEIYVQTATDQEITLLIGG

Core:

AGSGFVKTLTKDCPGFLSNVCVNIGFISGCKNC

Core with dehydrations:

AGDhaGFVKDhbLDhbKDCysPGFLDhaNVCysVNIGFIDhaGCysKNCys

antiSMASH-DB 4.0 matches for suiA

100.0%

NC_017621.1and 16 others:

NZ_CP039462.1 Lanthipeptides: E8M06_RS05390_lanthipeptideNZ_JABTZM010000032.1 Lanthipeptides: HRQ47_RS09675_lanthipeptideNZ_JAEVFQ010000010.1 Lanthipeptides: JNO64_RS06375_lanthipeptideNZ_JAFFHD010000003.1 Lanthipeptides: JN532_RS02075_lanthipeptideNZ_JAGFVG010000007.1 Lanthipeptides: J5581_RS04225_lanthipeptideNZ_JAIJZO010000001.1 Lanthipeptides: K5Q34_RS00965_lanthipeptideNZ_JAIMDS010000024.1 Lanthipeptides: K6V32_RS10650_lanthipeptideNZ_JAJUWV010000001.1 Lanthipeptides: LZF89_RS05505_lanthipeptideNZ_JAMDIS010000017.1 Lanthipeptides: M5P45_RS08180_lanthipeptideNZ_JAMYIU010000001.1 Lanthipeptides: NKE44_RS01780_lanthipeptideNZ_JAMYIX010000001.1 Lanthipeptides: NKE54_RS02675_lanthipeptideNZ_JAMYIY010000001.1 Lanthipeptides: NKE64_RS02785_lanthipeptideNZ_JAMYJP010000014.1 Lanthipeptides: NKE68_RS07350_lanthipeptideNZ_LR738722.1 Lanthipeptides: STREPSUIS_RS03955_lanthipeptideNZ_VZMP01000023.1 Lanthipeptides: F6P50_RS09295_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05700_lanthipeptide

Lanthipeptides: SSUD12_RS06540_lanthipeptide

AGSGFVKTLTKDCPGFLSNVCVNIGFISGCKNC

93.9%

NZ_AQQB01000068.1and 6 others:

NZ_BCEY01000024.1 Lanthipeptides: GOZ53_RS05100_lanthipeptideNZ_BCEZ01000067.1 Lanthipeptides: GOZ55_RS11230_lanthipeptideNZ_BCFC01000053.1 Lanthipeptides: GOZ35_RS07920_lanthipeptideNZ_BCFG01000017.1 Lanthipeptides: GOZ50_RS03220_lanthipeptideNZ_BCFI01000009.1 Lanthipeptides: GOZ54_RS02495_lanthipeptideNZ_CP019557.1 Lanthipeptides: BZG42_RS05725_lanthipeptide

Lanthipeptides: K738_RS01000000110290_lanthipeptide

AGSGFVKTLTKDCPGFLSNVCVNIGFISGCKNC

AGSG VKTLTKDCPGFLSN+CVNIGFISGCKNC

AGSGLVKTLTKDCPGFLSNICVNIGFISGCKNC

58.8%

NZ_CP040409.1and 4 others:

NZ_CP040414.1 Lanthipeptides: FE331_RS04020_lanthipeptideNZ_CP040415.1 Lanthipeptides: allorf_0721024_0721203_lanthipeptideNZ_CP040417.1 Lanthipeptides: FE328_RS00745_lanthipeptideNZ_CP040424.1 Lanthipeptides: FE321_RS03445_lanthipeptide

Lanthipeptides: FE336_RS03450_lanthipeptide

GSGFVKTLTKDCPGFLSNVCVNIGFISGCKNC

G G +KTLTKDCPG +S+VCVN+ +S CK C

GPGLLKTLTKDCPGTVSDVCVNLAVVSTCKKC

with 41 more sequence matches

Only the first 10 are displayed here.

54.5%

NZ_CP058255.1:

Lanthipeptides: HW369_RS18920_lanthipeptide

VKTLTKDCPGFLSNVCVNIGFISGCKNC

V T+TKDCP +S+VCV FIS CKNC

VPTITKDCPNTVSSVCVTFPFISACKNC

50.0%

NZ_CM000731.1and 2 others:

NZ_CP043834.1 Lanthipeptides: F0362_RS30375_lanthipeptideNZ_NVOB01000050.1 Lanthipeptides: CON62_RS29235_lanthipeptide

Lanthipeptides: BCERE0020_RS28875_lanthipeptide

AGSGFVKTLTKDCPGFLSNVCVNIGFISGCKNC

AG G+V+TLTKDCP CV I CK C

AGPGWVETLTKDCPWKQPAACVIIMGQKICKKC

50.0%

NZ_CP036053.1and 7 others:

NZ_JAOPRA010000024.1 Lanthipeptides: OCE16_RS27090_lanthipeptideNZ_KB976667.1 Lanthipeptides: IG5_RS06165_lanthipeptideNZ_LDKD02000003.1 Lanthipeptides: ABH17_RS27060_lanthipeptideNZ_NUAO01000019.1 Lanthipeptides: CN544_RS19345_lanthipeptideNZ_NVFH01000027.1 Lanthipeptides: COL40_RS24675_lanthipeptideNZ_NVHY01000021.1 Lanthipeptides: COM05_RS26660_lanthipeptideNZ_NVOV01000033.1 Lanthipeptides: CON78_RS26470_lanthipeptide

Lanthipeptides: EXW64_RS27135_lanthipeptide

AGSGFVKTLTKDCPGFLSNVCVNIGFISGCKNC

AG G+V+TLTKDCP CV I CK C

AGPGWVETLTKDCPWKQPGACVIIMGQKICKKC

50.0%

NZ_JH792312.1and 1 other:

NZ_QNRN01000010.1 Lanthipeptides: DET63_RS17570_lanthipeptide

Lanthipeptides: IIG_RS24665_lanthipeptide

AGSGFVKTLTKDCPGFLSNVCVNIGFISGCKNC

AG G+V+TLTKDCP + CV I CK C

AGPGWVETLTKDCPWNVPVACVTIMGQRICKKC

50.0%

NZ_KB976276.1:

Lanthipeptides: IIC_RS09105_lanthipeptide

AGSGFVKTLTKDCPGFLSNVCVNIGFISGCKNC

AG G+V+TLTKDCP CV I CK C

AGPGWVETLTKDCPWKQPVACVIIMGQKICKKC

48.5%

NZ_CP040409.1and 3 others:

NZ_CP040415.1 Lanthipeptides: FE330_RS03440_lanthipeptideNZ_CP040417.1 Lanthipeptides: FE328_RS00755_lanthipeptideNZ_CP040424.1 Lanthipeptides: FE321_RS03455_lanthipeptide

Lanthipeptides: FE336_RS03460_lanthipeptide

AGSGFVKTLTKDCPGFLSNVCVNIGFISGCKNC

G G V+TLTKDCP + VC F CK C

VGPGLVRTLTKDCPNVVPKVC----FDGNCKYC

48.5%

NZ_CP040414.1:

Lanthipeptides: FE331_RS04030_lanthipeptide

AGSGFVKTLTKDCPGFLSNVCVNIGFISGCKNC

G G V+TLTKDCP + VC F CK C

VGPGLVRTLTKDCPNVVPKVC----FDGKCKYC

47.1%

NZ_CM000748.1and 1 other:

NZ_JAIPUK010000011.1 Lanthipeptides: K9P71_RS26815_lanthipeptide

Lanthipeptides: BTHUR0003_RS30910_lanthipeptide

GSGFVKTLTKDCPGFLSNVCVNIGFISGCKNC

G G+V+TLTKDCP + CV I CK C

GPGWVETLTKDCPWNMPVACVTIMGQRICKKC

47.1%

NZ_CP036100.1and 1 other:

NZ_CP072062.1 Lanthipeptides: J5V93_RS29280_lanthipeptide

Lanthipeptides: EXW47_RS29185_lanthipeptide

AGSGFVKTLTKDCPGFLSNVCVNIGFISGCKNC

AG G+V+T+TKDCP + CV I CK C

AGPGWVETVTKDCPWNVPVACVTIMGQRICKKC

47.1%

NZ_FNYB01000007.1and 1 other:

NZ_KB976303.1 Lanthipeptides: IGY_RS28100_lanthipeptide

Lanthipeptides: BMZ34_RS15340_lanthipeptide

GSGFVKTLTKDCPGFLSNVCVNIGFISGCKNC

G G+++TLTKDCP +CV I I CK C

GPGYIETLTKDCPRVTPQICVPINGIWTCKRC

MIBiG 4.0 matches for suiA

15.2%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

TLTKDC

TLTK+C

TLTKEC

suiI

Leader:

MKKVIPYA

Core:

LLTLSMFFLFNAIRIFLESRSLYVVDVLLFIVFLVCSLKFRKQ

Core with dehydrations:

LLDhbLDhaMFFLFNAIRIFLEDhaRDhaLYVVDVLLFIVFLVCysDhaLKFRKQ

antiSMASH-DB 4.0 matches for suiI

100.0%

NZ_CP039462.1and 1 other:

NZ_VZNS01000007.1 Lanthipeptides: allorf_81390_81545_lanthipeptide

Lanthipeptides: allorf_1067807_1067962_lanthipeptide

LLTLSMFFLFNAIRIFLESRSLYVVDVLLFIVFLVCSLKFRKQ

97.7%

NZ_JAIJZO010000001.1and 4 others:

NZ_JAMYIU010000001.1 Lanthipeptides: allorf_0361876_0362031_lanthipeptideNZ_JAMYIX010000001.1 Lanthipeptides: allorf_556968_557123_lanthipeptideNZ_JAMYJP010000014.1 Lanthipeptides: allorf_39301_39456_lanthipeptideNZ_VZMP01000023.1 Lanthipeptides: allorf_16617_16772_lanthipeptide

Lanthipeptides: allorf_187573_187728_lanthipeptide

LLTLSMFFLFNAIRIFLESRSLYVVDVLLFIVFLVCSLKFRKQ

LLTLSMFFLFNAIRI+LESRSLYVVDVLLFIVFLVCSLKFRKQ

LLTLSMFFLFNAIRIYLESRSLYVVDVLLFIVFLVCSLKFRKQ

95.3%

NZ_JABTZM010000032.1and 1 other:

NZ_JAMYIY010000001.1 Lanthipeptides: allorf_562774_562929_lanthipeptide

Lanthipeptides: allorf_11223_11378_lanthipeptide

LLTLSMFFLFNAIRIFLESRSLYVVDVLLFIVFLVCSLKFRKQ

LLTLSMFFLFNAIRI+LESRSLYVVDVLLFIVFLVCS KFRKQ

LLTLSMFFLFNAIRIYLESRSLYVVDVLLFIVFLVCSFKFRKQ

with 3 more sequence matches

95.3%

NZ_JAMDIS010000017.1:

Lanthipeptides: allorf_28456_28611_lanthipeptide

LLTLSMFFLFNAIRIFLESRSLYVVDVLLFIVFLVCSLKFRK

LLTLSMFFLFNAIRI+LESRSLYVVDVLLFIVFLVCSLKFRK

LLTLSMFFLFNAIRIYLESRSLYVVDVLLFIVFLVCSLKFRK

95.3%

NZ_LR738722.1:

Lanthipeptides: allorf_0764715_0764870_lanthipeptide

LLTLSMFFLFNAIRIFLESRSLYVVDVLLFIVFLVCSLKFRKQ

LLTLSM FLFNAIRI+LESRSLYVVDVLLFIVFLVCSLKFRKQ

LLTLSMVFLFNAIRIYLESRSLYVVDVLLFIVFLVCSLKFRKQ

93.0%

NC_017621.1and 5 others:

NZ_JAEVFQ010000010.1 Lanthipeptides: allorf_48166_48321_lanthipeptideNZ_JAFFHD010000003.1 Lanthipeptides: allorf_019495_019650_lanthipeptideNZ_JAGFVG010000007.1 Lanthipeptides: allorf_15653_15808_lanthipeptideNZ_JAIMDS010000024.1 Lanthipeptides: allorf_20304_20459_lanthipeptideNZ_JAJUWV010000001.1 Lanthipeptides: allorf_1092541_1092696_lanthipeptide

Lanthipeptides: allorf_1305332_1305487_lanthipeptide

LLTLSMFFLFNAIRIFLESRSLYVVDVLLFIVFLVCSLKFRKQ

LLTLSMFFLFNAIRI+LESRSLYVVDVLLF+VFLVCS KFRKQ

LLTLSMFFLFNAIRIYLESRSLYVVDVLLFLVFLVCSFKFRKQ

allorf_00423_00602

Leader:

MEALRHCPEKWKAHPTGKHAPGGGYLSLYYQRELRQLSLADTGEQAQVYHS

Core:

DNXLKRSC

Core with dehydrations:

DNXLKRDhaCys

allorf_12434_12583

Leader:

MRFGVFRDERHFS

Core:

DCHLFTGFTLKKTSLGFNIVGISLIFRIDTVDLCWK

Core with dehydrations:

DCysHLFDhbGFDhbLKKDhbDhaLGFNIVGIDhaLIFRIDDhbVDLCysWK

antiSMASH-DB 4.0 matches for allorf_12434_12583

100.0%

NZ_CP039462.1and 3 others:

NZ_JAMDIS010000017.1 Lanthipeptides: allorf_29202_29351_lanthipeptideNZ_LR738722.1 Lanthipeptides: allorf_0765461_0765610_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: allorf_80650_80799_lanthipeptide

Lanthipeptides: allorf_1067067_1067216_lanthipeptide

DCHLFTGFTLKKTSLGFNIVGISLIFRIDTVDLCWK

MIBiG 4.0 matches for allorf_12434_12583

16.7%

BGC0000580.3 (EGD17354.1):

Lasso peptide: xanthomonin II or xanthomonin I

GFNIVGIS

GFN+ GIS

GFNVPGIS

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

suiA - Class II

Cleavage pHMM score: -6.00

RODEO score: 0

Monoisotopic mass: 3288.6 Da

Molecular weight: 3290.8 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3308.9 Da N = 1

suiI - Class II

Cleavage pHMM score: -4.90

RODEO score: 0

Monoisotopic mass: 5050.9 Da

Molecular weight: 5054.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 5072.2 Da N = 1; 5090.2 Da N = 2; 5108.2 Da N = 3; 5126.3 Da N = 4

allorf_00423_00602 - Class II

Cleavage pHMM score: -4.30

RODEO score: 0

Monoisotopic mass: 816.4 Da

Molecular weight: 816.9 Da

Number of bridges: 1

allorf_12434_12583 - Class II

Cleavage pHMM score: -6.40

RODEO score: 0

Monoisotopic mass: 3992.2 Da

Molecular weight: 3994.7 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4012.7 Da N = 1; 4030.7 Da N = 2; 4048.8 Da N = 3; 4066.8 Da N = 4