BGC0001812 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001812 (Micromonospora chalcea subsp. izumensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	73,895	High	tylactone	PKS

BGC0001812 - Region 1 - T1PKS

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Location: 1 - 73,895 nt. (total: 73,895 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 73,896
Label		BGC0001812

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

juvC: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

juvD: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

juvFI: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

juvG: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: acylase aminotransferase glycosyltransferase methyltransferase

juvEIV: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

juvFII: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

juvFIII: methyltransferase

smcogs: SMCOG1248: methyltransferase

juvFIV: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Hydrolases: esterase

juvB: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: synthase

juvEI: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

juvEII: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

juvEIII: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

juvEV: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001812.3	1.00	PKS	tylactone	Micromonospora chalcea subsp. izumensis
BGC0002086.3	0.92	PKS	rosamicin	Micromonospora carbonacea
BGC0001276.3	0.77	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000018.5	0.75	PKS	angolamycin	Streptomyces eurythermus
BGC0000041.3	0.73	PKS	oronofacic acid	Pseudomonas syringae
BGC0000113.5	0.72	PKS	niddamycin	Streptomyces caelestis
BGC0000166.5	0.71	PKS	tylactone	Streptomyces fradiae
BGC0001273.3	0.67	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.67	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.67	PKS	(-)-Mellein	Parastagonospora nodorum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001812.3	1.00	PKS	tylactone	Micromonospora chalcea subsp. izumensis
BGC0002086.3	0.92	PKS	rosamicin	Micromonospora carbonacea
BGC0001276.3	0.77	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000018.5	0.75	PKS	angolamycin	Streptomyces eurythermus
BGC0000041.3	0.73	PKS	oronofacic acid	Pseudomonas syringae
BGC0000113.5	0.72	PKS	niddamycin	Streptomyces caelestis
BGC0000166.5	0.71	PKS	tylactone	Streptomyces fradiae
BGC0001273.3	0.67	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.67	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.67	PKS	(-)-Mellein	Parastagonospora nodorum

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 72907:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - Me-ccmal - Me-ccmal) + (ccmal) + (Me-ohmal - redemal) + (Me-ohmal) + (ohmal)
Non-colinear ordering:: juvEI + juvEII + juvEIII + juvEIV + juvEV

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

juvEI: mmal - mmal - mmal

PKS_AT (532..835): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 190.3
Ethylmalonyl-CoA: 169.8
Methoxymalonyl-CoA: 152.2
2-Methylbutyryl-CoA: 120.8
trans-1,2-CPDA: 103.0
Propionyl-CoA: 91.4
Malonyl-CoA: 81.9
Isobutyryl-CoA: 77.9
CHC-CoA: 74.8
Benzoyl-CoA: 70.0
Acetyl-CoA: 36.7
inactive: 27.0
fatty_acid: 25.4
3-Methylbutyryl-CoA: 12.7

PKS_AT (1575..1878): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 191.6
Ethylmalonyl-CoA: 169.8
Methoxymalonyl-CoA: 149.4
2-Methylbutyryl-CoA: 117.9
trans-1,2-CPDA: 106.3
Propionyl-CoA: 91.8
Malonyl-CoA: 81.5
Isobutyryl-CoA: 71.9
CHC-CoA: 68.2
Benzoyl-CoA: 66.7
Acetyl-CoA: 35.8
inactive: 27.0
fatty_acid: 23.7
3-Methylbutyryl-CoA: 15.1

PKS_AT (3090..3390): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 189.3
Ethylmalonyl-CoA: 166.5
Methoxymalonyl-CoA: 147.0
2-Methylbutyryl-CoA: 114.8
trans-1,2-CPDA: 102.2
Propionyl-CoA: 92.2
Malonyl-CoA: 81.2
Isobutyryl-CoA: 71.8
CHC-CoA: 69.0
Benzoyl-CoA: 66.8
Acetyl-CoA: 36.6
inactive: 26.4
fatty_acid: 23.3
3-Methylbutyryl-CoA: 14.4

juvEII: mal

PKS_AT (601..900): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 203.1
inactive: 107.5
Methylmalonyl-CoA: 73.8
Methoxymalonyl-CoA: 73.0
Ethylmalonyl-CoA: 44.2
Isobutyryl-CoA: 44.0
Propionyl-CoA: 30.6
Benzoyl-CoA: 23.7
CHC-CoA: 21.7
trans-1,2-CPDA: 14.7
2-Methylbutyryl-CoA: 12.9
Acetyl-CoA: 12.7
fatty_acid: 9.6
3-Methylbutyryl-CoA: 0.0

juvEIII: mmal - emal

PKS_AT (595..898): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 190.8
Ethylmalonyl-CoA: 171.1
Methoxymalonyl-CoA: 151.0
2-Methylbutyryl-CoA: 119.6
trans-1,2-CPDA: 104.9
Propionyl-CoA: 90.6
Malonyl-CoA: 79.0
Isobutyryl-CoA: 76.0
Benzoyl-CoA: 68.2
CHC-CoA: 68.1
Acetyl-CoA: 36.1
inactive: 27.0
fatty_acid: 25.4
3-Methylbutyryl-CoA: 12.8

PKS_AT (2113..2411): emal

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Methylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 235.2
Methylmalonyl-CoA: 202.9
Methoxymalonyl-CoA: 180.1
trans-1,2-CPDA: 166.5
2-Methylbutyryl-CoA: 159.8
Propionyl-CoA: 121.3
CHC-CoA: 98.1
Malonyl-CoA: 83.6
Isobutyryl-CoA: 72.1
Benzoyl-CoA: 61.4
Acetyl-CoA: 59.5
fatty_acid: 48.6
3-Methylbutyryl-CoA: 34.9
inactive: 16.4

juvEIV: mmal

PKS_AT (574..871): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 204.3
Ethylmalonyl-CoA: 190.5
Methoxymalonyl-CoA: 169.1
2-Methylbutyryl-CoA: 138.5
trans-1,2-CPDA: 128.2
Propionyl-CoA: 97.8
Malonyl-CoA: 85.8
CHC-CoA: 85.1
Isobutyryl-CoA: 81.2
Benzoyl-CoA: 56.3
3-Methylbutyryl-CoA: 38.3
fatty_acid: 38.2
Acetyl-CoA: 29.8
inactive: 17.5

juvEV: mal

PKS_AT (568..864): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.3
inactive: 114.1
Methoxymalonyl-CoA: 64.7
Methylmalonyl-CoA: 52.3
Propionyl-CoA: 28.3
Isobutyryl-CoA: 22.1
Benzoyl-CoA: 20.0
Acetyl-CoA: 17.8
fatty_acid: 14.0
CHC-CoA: 12.6
Ethylmalonyl-CoA: 12.2
2-Methylbutyryl-CoA: 11.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor