BGC0001820 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001820 (Gliocladium sp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS	1	46,319	High	verticillin	NRPS:Type I

BGC0001820 - Region 1 - NRPS

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Location: 1 - 46,319 nt. (total: 46,319 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 46,320
Label		BGC0001820

Tailoring functions

Oxidoreductases: oxygenase reductase

verB: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

verC: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

verL: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

verT: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

Transferases: aminotransferase methyltransferase sulfotransferase

verG: glutathione S-transferase

smcogs: SMCOG1193: glutathione S-transferase

verI: aminotransferase

smcogs: SMCOG1019: aminotransferase

verM: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Ligases: ligase

verP: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001820.3	0.99	NRPS	verticillin	Gliocladium sp.
BGC0001585.3	0.68	other (other)	melinacidin IV	Escovopsis weberi
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002164.2	0.67	NRPS	peramine	Epichloe festucae
BGC0002286.3	0.65	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.63	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001641.4	0.62	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000321.4	0.62	NRPS	chaetocin	Collariella virescens
BGC0002276.2	0.57	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000900.5	0.55	other (other)	ferrichrome	Aspergillus oryzae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001820.3	0.99	NRPS	verticillin	Gliocladium sp.
BGC0001585.3	0.68	other (other)	melinacidin IV	Escovopsis weberi
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002164.2	0.67	NRPS	peramine	Epichloe festucae
BGC0002286.3	0.65	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.63	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001641.4	0.62	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000321.4	0.62	NRPS	chaetocin	Collariella virescens
BGC0002276.2	0.57	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000900.5	0.55	other (other)	ferrichrome	Aspergillus oryzae

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 46319:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ser - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

verP: Ser - X

Search NORINE for peptide: strict or relaxed

AMP-binding (10..405): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DACAIGASMK
Nearest Stachelhaus code(s):: Ser DACALGASMK (82% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (1087..1469): X

nrpys: Gly, Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVMAYCAILK
Nearest Stachelhaus code(s):: Ala DVFIYAAILK (47% 8Å match)
Stachelhaus code match:: 70% (weak)

Link to PARAS substrate predictor